Tumor targeting and penetrating biomimetic mesoporous polydopamine nanoparticles facilitate photothermal killing and autophagy blocking for synergistic tumor ablation

Huang, Xueqin1,3,4; Chen, Lingzhi5; Lin, Yongjian5; Tou, Kai Ip6; Cai, Huaihong5; Jin, Hua2; Lin, Wensen2; Zhang, Jianglin; Cai, Jiye3,5; Zhou, Haibo1,4; Pi, Jiang2

2021-12-01

10.1016/j.actbio.2021.09.030

Acta Biomaterialia   影响因子和分区

1742-7061

1878-7568

["The synergistic manipulation of autophagy blocking with tumor targeting and penetration effects to enhance cancer cell killing during photothermal therapy (PIT) remains a substantial challenge. Herein, we fabricated a biomimetic nanoplatform by precisely coating homologous prostate cancer cell membranes (CMs) onto the surface of mesoporous polydopamine nanoparticles (mPDA NPs) encapsulating the autophagy inhibitor chloroquine (CQ) for synergistically manipulating PIT and autophagy for anticancer treatment. The resulting biomimetic mPDA@CMs NPs-CQ system could escape macrophage phagocytosis, overcome the vascular barrier, and home in the homologous prostate tumor xenograft with high tumor targeting and penetrating efficiency. The mPDA NPs core endowed the mPDA@CMs NPs-CQ with good photothermal capability to mediate PIT killing of prostate cancer cells, while NIR-triggered CQ release from the nanosystem further arrested PIT-induced protective autophagy of cancer cells, thus weakening the resistance of prostate cancer cells to PIT. This combined PIT killing and autophagy blocking anticancer strategy could induce significant autophagosome accumulation, ROS generation, mitochondrial damage, endoplasmic reticulum stress, and apoptotic signal transduction, which finally results in synergistic prostate tumor ablation in vivo. This prostate cancer biomimetic nanosystem with synergistically enhanced anticancer efficiency achieved by manipulating PIT killing and autophagy blocking is expected to serve as a more effective anticancer strategy against prostate cancer.","Statement of significance","Autophagy is considered as one of the most efficient rescuer and reinforcement mechanisms of cancer cells against photothermal therapy (PIT)-induced cancer cell eradication. How to synergistically manipulate autophagy blocking with significant tumor targeting and penetration to enhance PIT-mediated cancer cell killing remains a substantial challenge. Herein, we fabricated a biomimetic nanoplatform by precisely coating homologous cancer cell membranes onto the surface of mesoporous polydopamine nanoparticles with encapsulation of the autophagy inhibitor chloroquine for synergistic antitumor treatment with high tumor targeting and penetrating efficiency both in vitro and in vivo. This biomimetic nanosystem with synergistically enhanced anticancer efficiency by manipulating PIT killing and autophagy blocking is expected to serve as a more effective anticancer strategy. (C) 2021 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved."]

Biomimetic nanoplatform Mesoporous polydopamine nanoparticles Photothermal therapy Autophagy blocking Synergistic anticancer effects

SCI ; EI

英语

第一 ; 通讯

National Natural Science Foundation of China[81773684,81801649] ; Guangdong Natural Science Funds for Distinguished Young Scholars[2018B030306033] ; Funds for PHD researchers of Guangdong Medical University in 2021[4SG21236G] ; Pearl River S&T Nova Program of Guangzhou[201806010060] ; Guangzhou Science and Technology Project[201904010273] ; Macau Science and Technology Development Fund[028/2014/A1] ; Natural Science Foundation of Guangdong Province[2018A0303130002] ; Project of Educational Commission of Guangdong Province of China[2021KTSCX038]

Engineering ; Materials Science

Engineering, Biomedical ; Materials Science, Biomaterials

WOS:000735938500002

ELSEVIER SCI LTD

Web of Science

1.Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1, Dept Dermatol,Shenzhen Peoples Hosp,Clin Med Coll, Shenzhen 518020, Guangdong, Peoples R China
2.Guangdong Med Univ, Inst Clin Lab Med, Sch Med Technol, Dept Clin Immunol,Guangdong Prov Key Lab Med Mol, Dongguan 523808, Guangdong, Peoples R China
3.Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau 000583, Peoples R China
4.Jinan Univ, Inst Pharmaceut Anal, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China
5.Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China
6.Hosp Macau Univ Sci & Technol, Dept Pathol, Macau 000583, Peoples R China

Huang, Xueqin,Chen, Lingzhi,Lin, Yongjian,et al. Tumor targeting and penetrating biomimetic mesoporous polydopamine nanoparticles facilitate photothermal killing and autophagy blocking for synergistic tumor ablation[J]. Acta Biomaterialia,2021,136.

Huang, Xueqin.,Chen, Lingzhi.,Lin, Yongjian.,Tou, Kai Ip.,Cai, Huaihong.,...&Pi, Jiang.(2021).Tumor targeting and penetrating biomimetic mesoporous polydopamine nanoparticles facilitate photothermal killing and autophagy blocking for synergistic tumor ablation.Acta Biomaterialia,136.

Huang, Xueqin,et al."Tumor targeting and penetrating biomimetic mesoporous polydopamine nanoparticles facilitate photothermal killing and autophagy blocking for synergistic tumor ablation".Acta Biomaterialia 136(2021).