A Regioselectively Oxidized 2D Bi/BiOx Lateral Nano-Heterostructure for Hypoxic Photodynamic Therapy

Qiu, Meng1,2; Wang, Dou3; Huang, Hao1; Yin, Teng1; Bao, Wenli1; Zhang, Bin1; Xie, Zhongjian1; Xie, Ni1; Wu, Zongze3; Ge, Chenchen3; Wang, Qi4; Gu, Meng4; Kutscher, Hilliard L.5,6,7; Liu, Liping3; Bao, Shiyun3; Prasad, Paras N.5; Zhang, Han1

2021-10-01

10.1002/adma.202102562

ADVANCED MATERIALS   影响因子和分区

0935-9648

1521-4095

Optoelectronic science and 2D nanomaterial technologies are currently at the forefront of multidisciplinary research and have numerous applications in electronics and photonics. The unique energy and optically induced interfacial electron transfer in these nanomaterials, enabled by their relative band alignment characteristics, can provide important therapeutic modalities for healthcare. Given that nano-heterostructures can facilitate photoinduced electron-hole separation and enhance generation of reactive oxygen species (ROS), 2D nano-heterostructure-based photosensitizers can provide a major advancement in photodynamic therapy (PDT), to overcome the current limitations in hypoxic tumor microenvironments. Herein, a bismuthene/bismuth oxide (Bi/BiOx)-based lateral nano-heterostructure synthesized using a regioselective oxidation process is introduced, which, upon irradiation at 660 nm, effectively generates O-1(2) under normoxia but produces cytotoxic center dot OH and H-2 under hypoxia, which synergistically enhances PDT. Furthermore, this Bi/BiOx nano-heterostructure is biocompatible and biodegradable, and, with the surface molecular engineering used here, it improves tumor tissue penetration and increases cellular uptake during in vitro and in vivo experiments, yielding excellent oxygen-independent tumor ablation with 660 nm irradiation, when compared with traditional PDT agents.

2D materials bismuthene hypoxia lateral nano-heterostructures photodynamic therapy

SCI ; EI

英语

NI论文

通讯

National Natural Science Foundation of China["U1801254",61961136001,"U1803128"] ; State Key Research Development Program of China[2019YFB2203503] ; Taishan Scholar Project of Shandong Province[tsqn201909054] ; Science and Technology Innovation Commission of Shenzhen["KQTD2015032416270385","JCYJ20150625103619275","JCYJ20180305124854790","JCYJ20180507181817604"] ; Natural Science Foundation of Guangdong Province[2018A030310500]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000706599200001

WILEY-V C H VERLAG GMBH

20214211021520

Biocompatibility ; Irradiation ; Molecular oxygen ; Nanostructured materials ; Photosensitizers ; Regioselectivity ; Tumors

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Immunology:461.9.1 ; Light/Optics:741.1 ; Nanotechnology:761 ; Chemical Reactions:802.2 ; Inorganic Compounds:804.2 ; Crystalline Solids:933.1

MATERIALS SCIENCE

Web of Science

1.Shenzhen Univ, Guangdong Prov Inst Microscale Optoelect, Minist Educ,Shenzhen Peoples Hosp 2, Key Lab Optoelect Devices Syst,Affiliated Hosp 1, Shenzhen 518060, Peoples R China
2.Ocean Univ China, Minist Educ, Key Lab Marine Chem Theory & Technol, Qingdao 266100, Peoples R China
3.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen Peoples Hosp, Shenzhen 518020, Peoples R China
4.South Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China
5.Univ Buffalo State Univ New York, Dept Chem, Inst Lasers Photon & Biophoton, Buffalo, NY 14260 USA
6.Univ Buffalo State Univ New York, Dept Med, Buffalo, NY 14203 USA
7.Univ Buffalo State Univ New York, Dept Anesthesiol, Buffalo, NY 14203 USA

Qiu, Meng,Wang, Dou,Huang, Hao,et al. A Regioselectively Oxidized 2D Bi/BiOx Lateral Nano-Heterostructure for Hypoxic Photodynamic Therapy[J]. ADVANCED MATERIALS,2021,33.

Qiu, Meng.,Wang, Dou.,Huang, Hao.,Yin, Teng.,Bao, Wenli.,...&Zhang, Han.(2021).A Regioselectively Oxidized 2D Bi/BiOx Lateral Nano-Heterostructure for Hypoxic Photodynamic Therapy.ADVANCED MATERIALS,33.

Qiu, Meng,et al."A Regioselectively Oxidized 2D Bi/BiOx Lateral Nano-Heterostructure for Hypoxic Photodynamic Therapy".ADVANCED MATERIALS 33(2021).