Vaspin Mediates the Intraorgan Crosstalk Between Heart and Adipose Tissue in Lipoatrophic Mice

Zhang，Donghui1,2; Zhu，Hong3; Zhan，Enbo1,2; Wang，Fan1,2; Liu，Yue4; Xu，Wei1,2; Liu，Xian5; Liu，Jingjin6; Li，Shufeng1,2; Pan，Yong7,8; Wang，Yongshun6; Cao，Wei1,2

2021-09-24

10.3389/fcell.2021.647131

Frontiers in Cell and Developmental Biology   影响因子和分区

2296-634X

Lipoatrophy is characterized as selective loss of adipose tissues, leading to the severity of cardiovascular disorders. Therefore, there was close intraorgan crosstalk between adipose tissue and cardiovascular in lipoatrophy. A-ZIP/F-1 mouse, a well-established lipoatrophic model, and primary cardiomyocytes were used for investigating the pathophysiological changes and molecular mechanisms. A-ZIP/F-1 mice had severe fat loss and impaired ventricular function during growth, but closely associated with the reduction of circulating vaspin levels. Administration of recombinant vaspin protein improved cardiac structural disorders, left ventricular dysfunction, and inflammatory response in lipoatrophic mice. In detail, vaspin decreased cardiac lipid deposits, but enhanced mitochondrial biogenesis and activities. Interestingly, A-ZIP/F-1 mice transplanted with normal visceral adipose tissues exhibited improvement in cardiac structural remodeling and mitochondrial function. Mechanistically, vaspin increased cardiac AKT activity, which guaranteed the mitochondrial benefits of vaspin in lipoatrophic mice and primary mouse cardiomyocytes. The present study suggested that vaspin possessed biological benefits in attenuating lipoatrophy-induced cardiomyopathy onset, and targeting vaspin/AKT signaling was a potential strategy to maintain heart metabolism.

adipose tissue AKT cardiomyopathy lipoatrophy mitochondria vaspin

SCI

英语

通讯

WOS:000705057800001

2-s2.0-85116933290

Scopus

1.Department of Cardiology,The Second Affiliated Hospital of Harbin Medical University,Harbin,China
2.The Key Laboratory of Myocardial Ischemia,Chinese Ministry of Education,Harbin,China
3.Department of Geriatrics,Xuanwu Hospital,Capital Medical University,Beijing,China
4.Department of Cardiology,The First Affiliated Hospital of Harbin Medical University,Harbin,China
5.Department of Cardiology,The Fourth Affiliated Hospital of Harbin Medical University,Harbin,China
6.Department of Cardiology,Shenzhen People’s Hospital,The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,China
7.Department of Pathophysiology,Shenzhen University,Shenzhen,China
8.Guangdong Provincial Key Laboratory of Genome Stability and Disease Prevention,Shenzhen,Guang Dong,China

Zhang，Donghui,Zhu，Hong,Zhan，Enbo,et al. Vaspin Mediates the Intraorgan Crosstalk Between Heart and Adipose Tissue in Lipoatrophic Mice[J]. Frontiers in Cell and Developmental Biology,2021,9.

Zhang，Donghui.,Zhu，Hong.,Zhan，Enbo.,Wang，Fan.,Liu，Yue.,...&Cao，Wei.(2021).Vaspin Mediates the Intraorgan Crosstalk Between Heart and Adipose Tissue in Lipoatrophic Mice.Frontiers in Cell and Developmental Biology,9.

Zhang，Donghui,et al."Vaspin Mediates the Intraorgan Crosstalk Between Heart and Adipose Tissue in Lipoatrophic Mice".Frontiers in Cell and Developmental Biology 9(2021).