Hollow ceo2 with ros-scavenging activity to alleviate colitis in mice

Yang，Jing1; Zhou，Jinzhe2; Zhao，Yingying1; Zhu，Liangchen2; Luo，Guanghong3; Ge，Bujun2

2021

10.2147/IJN.S317261

International Journal of Nanomedicine   影响因子和分区

1176-9114

1178-2013

Introduction: Excessive production of reactive oxygen species (ROS) to induce high oxidative stress is one of the main causes of colitis; thus, it has been regarded as a therapeutic target for colitis treatment. And the nanomaterial-based therapeutic strategies are effective against colitis. However, the previous elaborately designed materials exhibit limited application due to the uncertain biocompatibility and complicated manufacturing processes. Methods: In this study, the highly monodisperse hollow CeO nanoparticles (H-CeO ) with uniform morphology were obtained by in situ growing CeO on solid silica nanoparticles and subsequently removing the silica core. The H-CeO was further modified with PEG, which owned excellent biological stability and biocompatibility. The experimental model of colitis induced by dextran sulfate sodium (DSS) was used to investigate the anti-inflammatory effect of H-CeO-PEG. Results: The H-CeO-PEG showed good ROS scavenging efficacy and decreased the levels of proinflammatory cytokines (IL-6, IL-1β, IL-18, and TNF-α) in DSS-induced colitis mice. Furthermore, H-CeO-PEG inhibited the activation of the MAPK signalling pathway to alleviate colitis. Conclusion: This study reveals the therapeutic effects of CeO-based nanomedicine toward colitis and elucidates the specific signalling pathway involved, which provides potential alternative therapeutic options for patients with inflammation tissue.

Colitis Hollow CeO2 Inflammation MAPK signalling pathway ROS

英语

通讯

2-s2.0-85117305573

Scopus

1.Department of Gastroenterology,The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital,Jinan,China
2.Department of General Surgery,Tongji Hospital,Tongji University School of Medicine,Shanghai,China
3.Department of Radiation Oncology,Shenzhen People’s Hospital (The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,China

Yang，Jing,Zhou，Jinzhe,Zhao，Yingying,et al. Hollow ceo2 with ros-scavenging activity to alleviate colitis in mice[J]. International Journal of Nanomedicine,2021,16:6889-6904.

Yang，Jing,Zhou，Jinzhe,Zhao，Yingying,Zhu，Liangchen,Luo，Guanghong,&Ge，Bujun.(2021).Hollow ceo2 with ros-scavenging activity to alleviate colitis in mice.International Journal of Nanomedicine,16,6889-6904.

Yang，Jing,et al."Hollow ceo2 with ros-scavenging activity to alleviate colitis in mice".International Journal of Nanomedicine 16(2021):6889-6904.