High-level uric acid in asymptomatic hyperuricemia could be an isolated risk factor of cardio-cerebrovascular diseases: A prospective cohort study

Cheng，Zhiyuan1; Zheng，Tongzhang2; Zhang，Desheng4; Yang，Jingli3; Hu，Xiaobin3; Yin，Chun4; Ren，Xiaowei3; Li，Juansheng3; Shi，Dian2,5; Li，Na4; Zheng，Shan3; Wang，Minzhen3; Bai，Yana3

2021

10.1016/j.numecd.2021.08.043

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES   影响因子和分区

0939-4753

1590-3729

Background and aims: Whether the asymptomatic hyperuricemia (AH) raise the cardiovascular disease risk with or without hyperuricemia-related comorbidities still remains contentious. Our study was aimed to quantitatively access the incidence risk of coronary heart disease (CHD) and stroke associated with AH. Methods and results: In this prospective cohort study, multivariate-adjusted Cox regression models were applied to evaluate the risk of cardiovascular disease (CVD). Baseline serum uric acid beyond normouricemia (357 mmol/L) was quarterly stratified based on the distribution of healthy populations without CVD onset. 1062 CVD first-attack cases were collected among the 29,974 study population (age range: 18–91, mean age: 47.2 ± 13.9 years-old) with a mean follow-up duration of 5.78 ± 0.83 years. The AH showed overall non-association with the CVD incident. However, significantly increased adjusted hazard ratio (HR) of CVD with 95% confidence interval (CI) were observed when the fourth quartile compared with normouricemia stratum in the total cohort population (CHD: 1.42, 1.21–1.68; stroke: 1.27, 1.06–1.41), male (CHD: 1.26, 1.12–1.55), female (CHD: 1.34, 1.04–2.02; stroke: 2.06, 1.13–3.77) and aged over 50 years-old population. Meanwhile, the age-standardized incidence rate of CVD in the fourth quartile was 2–3 times higher than the normouricemia population. After excluded 14,464 baseline population with diabetes, dyslipidemia, and hypertension, consistent results were also observed in the AH population in absence of comorbidities (CHD: 1.51, 1.22–2.25; stroke: 1.68, 1.13–2.39). Conclusion: Asymptomatic hyperuricemia patients exposed to a higher level of uric acid (>=428 mmol/L) could significantly increase the incidence risk of CHD and stroke, with or without hyperuricemia-related comorbidities.

Asymptomatic hyperuricemia Coronary heart diseases Incidence risk Prospective cohort study Stroke

SCI

英语

第一

Lanzhou University[2018ldbrzd0 08] ; Natural Science Foundation of China[81673248] ; Foundation for the National Institutes of Health (U.S.) (NIH)[1R01ES029082]

Cardiovascular System & Cardiology ; Endocrinology & Metabolism ; Nutrition & Dietetics

Cardiac & Cardiovascular Systems ; Endocrinology & Metabolism ; Nutrition & Dietetics

WOS:000722579400018

ELSEVIER SCI LTD

CLINICAL MEDICINE

2-s2.0-85117238124

Scopus

1.School of Public Health and Emergency Management,Southern University of Science and Technology of China,Shenzhen,518055,China
2.Department of Epidemiology,School of Public Health,Brown University,Providence,02901,United States
3.Department of Epidemiology and Statistics,School of Public Health,Lanzhou University,Lanzhou,730000,China
4.Workers' Hospital of Jinchuan Corporation,Jinchuan Group CO.,LTD,Jinchang,737100,China
5.School of Basic Medical Science,Lanzhou University,Lanzhou,73000,China

Cheng，Zhiyuan,Zheng，Tongzhang,Zhang，Desheng,et al. High-level uric acid in asymptomatic hyperuricemia could be an isolated risk factor of cardio-cerebrovascular diseases: A prospective cohort study[J]. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES,2021,31(12).

Cheng，Zhiyuan.,Zheng，Tongzhang.,Zhang，Desheng.,Yang，Jingli.,Hu，Xiaobin.,...&Bai，Yana.(2021).High-level uric acid in asymptomatic hyperuricemia could be an isolated risk factor of cardio-cerebrovascular diseases: A prospective cohort study.NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES,31(12).

Cheng，Zhiyuan,et al."High-level uric acid in asymptomatic hyperuricemia could be an isolated risk factor of cardio-cerebrovascular diseases: A prospective cohort study".NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES 31.12(2021).