Intestinal microbiome and metabolome analyses reveal metabolic disorders in the early stage of renal transplantation

Ma, Chiyu1,2; He, Jingquan2; Lai, Liusheng1; Chen, Yumei2; Xue, Wen1; Chen, Jieping2; Dai, Weier3; Tang, Donge1,2; Yan, Qiang1; Dai, Yong1,2

2021-09-01

10.1039/d1mo00279a

MOLECULAR OMICS   影响因子和分区

2515-4184

Renal transplantation is the most effective treatment for end-stage renal disease, but the long-term prognosis of organs after transplantation is not ideal. In recent years, the importance of gut microbes and metabolites in the study of disease mechanisms has gradually received attention. However, the coordination between gut microbes and the metabolism of renal transplant patients needs further study. We integrated 16s sequencing and metabolomics data to describe the changes in the serum and fecal metabolites of renal transplant patients. Our data revealed that the gut microbial diversity decreased and the relative abundance of many bacteria, such as Enterococcus and Streptococcus, significantly changed after transplantation. In addition, a large number of amino acids and peptides in serum and feces significantly changed, suggesting an abnormal amino acid metabolism after transplantation. Spearman's correlation analysis revealed the changes in the co-metabolism pattern between gut microbes and the host metabolism after transplantation. Furthermore, Enterococcus was found to be correlated with renal functions and metabolites reflecting renal damage. This study provides potential gut microbes and metabolites impacting renal health, which helps in understanding the renal damage in patients with kidney transplantation.

SCI

英语

通讯

Natural Science Foundation of Guangxi[2017GXNSFAA198185] ; Guangxi Key Laboratory of Metabolic Diseases Research[20-065-76] ; Key Renal Laboratory of Shenzhen[ZDSYS2015430161623417] ; Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialities[SZGSP001]

Biochemistry & Molecular Biology

Biochemistry & Molecular Biology

WOS:000709890000001

ROYAL SOC CHEMISTRY

Web of Science

1.924 Hosp, Nephrol Dept, Guangxi Key Lab Metab Dis Res, Cent Lab Guilin, Guilin 541002, Peoples R China
2.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1, Clin Med Res Ctr,Clin Med Coll 2,Jinan Univ, Shenzhen 518020, Peoples R China
3.Univ Texas Austin, Coll Nat Sci, Austin, TX 78712 USA

Ma, Chiyu,He, Jingquan,Lai, Liusheng,et al. Intestinal microbiome and metabolome analyses reveal metabolic disorders in the early stage of renal transplantation[J]. MOLECULAR OMICS,2021.

Ma, Chiyu.,He, Jingquan.,Lai, Liusheng.,Chen, Yumei.,Xue, Wen.,...&Dai, Yong.(2021).Intestinal microbiome and metabolome analyses reveal metabolic disorders in the early stage of renal transplantation.MOLECULAR OMICS.

Ma, Chiyu,et al."Intestinal microbiome and metabolome analyses reveal metabolic disorders in the early stage of renal transplantation".MOLECULAR OMICS (2021).