南方科技大学知识苑(SUSTech KC): CSE1L silencing impairs tumor progression via MET/STAT3/PD-L1 signaling in lung cancer

题名	CSE1L silencing impairs tumor progression via MET/STAT3/PD-L1 signaling in lung cancer
作者	Liu, Weijun 1; Zhou, Zhiqing2 ; Li, Yu2 ; Xu, Jiali2 ; Shen, Yang 2 ; Luo, Suisui 2; Zhou, Yujie2 ; Wu, Xing 2; Zhao, Huijie2 ; Beer, David G.3; He, Yanli 4; Chen, Guoan2
通讯作者	He, Yanli; Chen, Guoan
发表日期	2021
发表期刊	American Journal of Cancer Research 影响因子和分区
ISSN	2156-6976
卷号	11 期号:9
摘要	CSE1L is involved in the cancer progression of several types of cancer. Its expression status, potential oncogenic role and underlying mechanism in lung cancer, however, are unclear. Here, we investigated CSE1L expression in primary lung adenocarcinoma based on multiple datasets and then investigated its oncologic role in lung cancer. We also examined the potential molecular mechanisms of CSE1L in cancer progression. CSE1L levels were increased in cancer as compared to normal lung tissues. CSE1L expression was higher in poorly-differentiated late stage and lymph node positive metastatic tumors. Higher CSE1L level was correlated with worse patient outcome. Knockdown of CSE1L using siRNAs impaired cell proliferation, invasion, migration and induced cell apoptosis. Mechanistically, MET, STAT3 and PD-L1 proteins were decreased upon CSE1L silencing. These results suggest that CSE1L may affect tumor progression through MET/STAT3/PD-L1 signaling. CSE1L may have potential as a biomarker and therapeutic target for lung cancer.
关键词	Lung cancer CSE1L MET STAT3 PD-L1
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	通讯
资助项目	Na-tional Natural Science Foundation of China (NSFC)[32070625,81873154]
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000707716300019
出版者	E-CENTURY PUBLISHING CORP
来源库	Web of Science
引用统计	被引频次[WOS]：6
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/254468
专题	南方科技大学医学院南方科技大学医学院_人类细胞生物和遗传学系
作者单位	1.Kunming Univ Sci & Technol, Affiliated Hosp, Peoples Hosp Yunnan Prov 1, Dept Anorectal Dis, Kunming 650032, Yunnan, Peoples R China 2.Southern Univ Sci & Technol, Sch Med, 1088 Xueyuan Ave, Shenzhen 518055, Guangzhou, Peoples R China 3.Univ Michigan, Dept Surg, Med Sch, Ann Arbor, MI 48109 USA 4.Guangzhou Univ Chinese Med, Sch Basic Med, Guangzhou 510006, Guangdong, Peoples R China
通讯作者单位	南方科技大学医学院
推荐引用方式 GB/T 7714	Liu, Weijun,Zhou, Zhiqing,Li, Yu,et al. CSE1L silencing impairs tumor progression via MET/STAT3/PD-L1 signaling in lung cancer[J]. American Journal of Cancer Research,2021,11(9).
APA	Liu, Weijun.,Zhou, Zhiqing.,Li, Yu.,Xu, Jiali.,Shen, Yang.,...&Chen, Guoan.(2021).CSE1L silencing impairs tumor progression via MET/STAT3/PD-L1 signaling in lung cancer.American Journal of Cancer Research,11(9).
MLA	Liu, Weijun,et al."CSE1L silencing impairs tumor progression via MET/STAT3/PD-L1 signaling in lung cancer".American Journal of Cancer Research 11.9(2021).