Usefulness of diffusion derived vessel density computed from a simplified IVIM imaging protocol: An experimental study with rat biliary duct blockage induced liver fibrosis

Hu, Gen-Wen1,2; Zheng, Cun-Jing3; Zhong, Wei-Xiang4; Zhuang, Dan-Ping1,2; Xiao, Ben-Heng3; Wang, Yi Xiang J.3

2021-12-01

10.1016/j.mri.2021.09.013

MAGNETIC RESONANCE IMAGING   影响因子和分区

0730-725X

1873-5894

["Objectives: Liver vessel density can be evaluated by DDVD (diffusion derived vessel density): DDVD(b0b1) = Sb0/ ROIarea0 - Sb1/ROIarea1, where Sb0 and Sb1 refer to the liver signal when b is 0 or 1 s/mm(2). Sb1 and ROIarea1 may be replaced by other b-values. With a rat biliary duct ligation (BDL) model, this study assesses the usefulness of liver DDVD computed from a simplified IVIM imaging protocol using b = 25 and b = 50 to replace b = 1 s/ mm(2), alone and in combination with other IVIM parameters.","Methods: Male Sprague-Dawley rats were used. The rat number was 5, 5, 5, and 3 respectively, for the timepoints of 7, 14, 21, 28 days post-BDL surgery. 12 rats had partial biliary duct recanalization performed after the rats had BDL for 7 days and then again followed-up for a mean of 14 days. Liver diffusion MRIs were acquired at 3.0 T with a b-value distribution of 0, 25, 50, 75, 100, 150, 300, 700, 1000 s/mm(2). DDVDmean (control rats n = 6) was the mean of DDVD(b0b25) and DDVD(b0b50). IVIM fitting started from b = 0 s/mm(2) with segmented fitting and a threshold b of 50 s/mm(2) (n = 5 for control rats). Three 3-D spaces were constructed using a combination of the four diffusion parameters.","Results: The control rats and BDL rats (n = 18) had a liver DDVDmean of 84.0 +/- 26.2 and 44.7 +/- 14.4 au/pixel (p < 0.001). All 3-D spaces totally separated healthy livers and all fibrotic livers (n = 30, BDL rats and recanalization rats). The mean relative distance between healthy liver cluster and fibrotic liver cluster was 0.331 for PF, Dslow, and Dfast; 0.381 for PF, D-fast, and DDVDmean; and 0.384 for PF, D-slow, and DDVDmean.","Conclusion: A combination of PF, D-slow, and D-fast allows total separation of healthy livers and fibrotic livers and the integration of DDVD improved the separation."]

Magnetic resonance imaging (MRI) Intravoxel incoherent motion (IVIM) Liver Fibrosis Biliary duct ligation

SCI

英语

其他

Shenzhen Basic Research Plan Fund Project[JCYJ20180228164641207] ; Cultivating Fund Project of Shenzhen People's Hospital[SYKYPY201933] ; Hong Kong GRF grant[14109218]

Radiology, Nuclear Medicine & Medical Imaging

Radiology, Nuclear Medicine & Medical Imaging

WOS:000708295300009

ELSEVIER SCIENCE INC

CLINICAL MEDICINE

Web of Science

1.Jinan Univ, Dept Radiol, Shenzhen Peoples Hosp, Clin Med Coll 2, Shenzhen, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Guangdong, Peoples R China
3.Chinese Univ Hong Kong, Fac Med, Dept Imaging & Intervent Radiol, Shatin, Hong Kong, Peoples R China
4.Zhejiang Univ, Affiliated Hosp 1, Dept Pathol, Sch Med, Hangzhou, Zhejiang, Peoples R China

Hu, Gen-Wen,Zheng, Cun-Jing,Zhong, Wei-Xiang,et al. Usefulness of diffusion derived vessel density computed from a simplified IVIM imaging protocol: An experimental study with rat biliary duct blockage induced liver fibrosis[J]. MAGNETIC RESONANCE IMAGING,2021,84.

Hu, Gen-Wen,Zheng, Cun-Jing,Zhong, Wei-Xiang,Zhuang, Dan-Ping,Xiao, Ben-Heng,&Wang, Yi Xiang J..(2021).Usefulness of diffusion derived vessel density computed from a simplified IVIM imaging protocol: An experimental study with rat biliary duct blockage induced liver fibrosis.MAGNETIC RESONANCE IMAGING,84.

Hu, Gen-Wen,et al."Usefulness of diffusion derived vessel density computed from a simplified IVIM imaging protocol: An experimental study with rat biliary duct blockage induced liver fibrosis".MAGNETIC RESONANCE IMAGING 84(2021).