南方科技大学知识苑(SUSTech KC): Efficient synthesis of primary and secondary amides via reacting esters with alkali metal amidoboranes

题名	Efficient synthesis of primary and secondary amides via reacting esters with alkali metal amidoboranes
作者	Guo, Yu 1; Wang, Ruo-Ya 1,2; Kang, Jia-Xin 1; Ma, Yan-Na 3,4; Xu, Cong-Qiao2 ; Li, Jun2,5,6 ; Chen, Xuenian 1,3,4
通讯作者	Li, Jun; Chen, Xuenian
发表日期	2021-10-13
DOI	10.1038/s41467-021-25836-5
发表期刊	NATURE COMMUNICATIONS 影响因子和分区
EISSN	2041-1723
卷号	12 期号:1
摘要	["Amides are one of the most important organic compounds that are widely applied in medicine, biochemistry, and materials science. To find an efficient synthetic method of amides is a challenge for organic chemistry. We report here a facile synthesis method of primary and secondary amides through a direct amidation of esters with sodium amidoboranes (NaNHRBH3, R = H, Me), at room temperature without using catalysts and other reagents. This process is rapid and chemoselective, and features quantitative conversion and wide applicability for esters tolerating different functional groups. The experimental and theoretical studies reveal a reaction mechanism with nucleophilic addition followed by a swift proton transfer-induced elimination reaction.","Amides are important organic compounds that are widely applied in medicine, biochemistry, and materials science. Here, the authors report a method for synthesis of primary and secondary amides through a direct amidation of esters with sodium amidoboranes (NaNHRBH3, R = H, Me), at room temperature without the use of catalysts."]
相关链接	[来源记录]
收录类别	SCI
语种	英语
重要成果	NI论文 ; NI论文 ; NI论文 ; NI论文 ; NI论文 ; NI论文 ; NI论文 ; NI论文 ; NI论文 ; NI论文 ; NI论文 ; NI论文 ; NI论文 ; NI论文 ; NI论文 ; NI论文 ; NI论文
学校署名	通讯
资助项目	National Natural Science Foundation of China["U1804253",21771057,22033005]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000707028100025
出版者	NATURE PORTFOLIO
来源库	Web of Science
引用统计	被引频次[WOS]：33
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/254476
专题	理学院_化学系
作者单位	1.Henan Normal Univ, Sch Chem & Chem Engn, Henan Key Lab Boron Chem & Adv Energy Mat, Xinxiang 453007, Henan, Peoples R China 2.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Peoples R China 3.Zhengzhou Univ, Green Catalysis Ctr, Zhengzhou 450001, Peoples R China 4.Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Peoples R China 5.Tsinghua Univ, Minist Educ, Dept Chem, Beijing 100084, Peoples R China 6.Tsinghua Univ, Minist Educ, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China
通讯作者单位	化学系
推荐引用方式 GB/T 7714	Guo, Yu,Wang, Ruo-Ya,Kang, Jia-Xin,et al. Efficient synthesis of primary and secondary amides via reacting esters with alkali metal amidoboranes[J]. NATURE COMMUNICATIONS,2021,12(1).
APA	Guo, Yu.,Wang, Ruo-Ya.,Kang, Jia-Xin.,Ma, Yan-Na.,Xu, Cong-Qiao.,...&Chen, Xuenian.(2021).Efficient synthesis of primary and secondary amides via reacting esters with alkali metal amidoboranes.NATURE COMMUNICATIONS,12(1).
MLA	Guo, Yu,et al."Efficient synthesis of primary and secondary amides via reacting esters with alkali metal amidoboranes".NATURE COMMUNICATIONS 12.1(2021).