Systematic proteomics analysis of lysine acetylation reveals critical features of placental proteins in pregnant women with preeclampsia

Yu Shangguan1,2,3; Wang, Yinglan1; Wei Shi1; Guo, Ruonan1; Zeng, Zhipeng1; Hu, Wenlong1; Cai, Wanxia1; Qiang Yan2,3; Yong Xu1; Tang, Donge1; Yong Dai1,2

2021-10-01

10.1111/jcmm.16997

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE   影响因子和分区

1582-1838

1582-4934

Preeclampsia (PE) is a dangerous hypertensive disorder that occurs during pregnancy. The specific aetiology and pathogenesis of PE have yet to be clarified. To better reveal the specific pathogenesis of PE, we characterized the proteome and acetyl proteome (acetylome) profile of placental tissue from PE and normal-term pregnancy by label-free quantification proteomics technology and PRM analysis. In this research, 373 differentially expressed proteins (DEPs) were identified by proteome analysis. Functional enrichment analysis revealed significant enrichment of DEPs related to angiogenesis and the immune system. COL12A1, C4BPA and F13A1 may be potential biomarkers for PE diagnosis and new therapeutic targets. Additionally, 700 Kac sites were identified on 585 differentially acetylated proteins (DAPs) by acetylome analyses. These DAPs may participate in the occurrence and development of PE by affecting the complement and coagulation cascades pathway, which may have important implications for better understand the pathogenesis of PE. In conclusion, this study systematically analysed the reveals critical features of placental proteins in pregnant women with PE, providing a resource for exploring the contribution of lysine acetylation modification to PE.

angiogenesis complement and coagulation cascades immune system lysine acetylation preeclampsia proteomics

SCI

英语

第一 ; 通讯

Science and Technology Planning Project of Guangdong Province, China[2017B020209001] ; Guangxi Key Laboratory of Metabolic Diseases Research[20-065-76] ; Natural Science Foundation of Guangxi[2017GXNSFAA198185] ; science and technology plan of Shenzhen[JCYJ20200109144218597] ; Sanming project of medicine in Shenzhen[SZSM201812078]

Cell Biology ; Research & Experimental Medicine

Cell Biology ; Medicine, Research & Experimental

WOS:000710874400001

WILEY

MOLECULAR BIOLOGY & GENETICS

Web of Science

1.Southern Univ Sci & Technol, Shenzhen Peoples Hosp,Clin Med Res Ctr, Affiliated Hosp 1,Guangdong Prov Engn Res Ctr Aut, Clin Med Coll 2,Jinan Univ,Shenzhen Engn Res Ctr, Shenzhen, Peoples R China
2.924st Hosp, Nephrol Dept, Guangxi Key Lab Metab Dis Res, Guilin, Peoples R China
3.Guangxi Normal Univ, Coll Life Sci, Guilin, Peoples R China

Yu Shangguan,Wang, Yinglan,Wei Shi,et al. Systematic proteomics analysis of lysine acetylation reveals critical features of placental proteins in pregnant women with preeclampsia[J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,2021.

Yu Shangguan.,Wang, Yinglan.,Wei Shi.,Guo, Ruonan.,Zeng, Zhipeng.,...&Yong Dai.(2021).Systematic proteomics analysis of lysine acetylation reveals critical features of placental proteins in pregnant women with preeclampsia.JOURNAL OF CELLULAR AND MOLECULAR MEDICINE.

Yu Shangguan,et al."Systematic proteomics analysis of lysine acetylation reveals critical features of placental proteins in pregnant women with preeclampsia".JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021).