Monitoring tumor growth with a novel NIR-II photoacoustic probe

Zha, Menglei1; Ni, Jen-Shyang2; Li, Yaxi1; Li, Kai1

2021

10.1016/bs.mie.2021.06.033

Methods in Enzymology   影响因子和分区

0076-6879

In this chapter, we designed and synthesized a series of thiadiazoloquinoxaline (TQ)-based semiconducting polymers (SPs) with a broad absorption covering from NIR-I to NIR-II regions. Theoretical calculation suggests that the BTD-TQE with ester-substituted TQ-acceptor shows a large dihedral angle and narrow adiabatic energy as well as low radiative decay, resulting in higher reorganization energy for efficient photoinduced nonradiative decay (PNRD). As a result, the obtained BDT-TQE SP-cored nanoparticles, a NIR-II PA probe, exhibit a highest NIR-II photothermal conversion efficiency (61.6%) and achieved PA tracking of in situ hepatic tumor growth for 20 days. Herein, we propose a strategy to construct an effective NIR-II photoacoustic reagent through the enhanced PNRD effect of twisted intramolecular charge transfer (TICT), thereby extending the application of NIR-II PA reagents in in vivo bioimaging.

BSCI ; SCI

英语

第一 ; 通讯

Acoustics ; Biochemistry & Molecular Biology ; Optics

Acoustics ; Biochemical Research Methods ; Biochemistry & Molecular Biology ; Optics

WOS:000709779300009

ELSEVIER ACADEMIC PRESS INC

Web of Science

1.Southern Univ Sci & Technol SUSTech, Dept Biomed Engn, Shenzhen Key Lab Smart Healthcare Engn, Shenzhen, Peoples R China
2.Natl Kaohsiung Univ Sci & Technol, Dept Chem & Mat Engn, Photosensit Mat Adv Res & Technol Ctr Photo SMART, Kaohsiung, Taiwan

Zha, Menglei,Ni, Jen-Shyang,Li, Yaxi,et al. Monitoring tumor growth with a novel NIR-II photoacoustic probe[J]. Methods in Enzymology,2021,657.

Zha, Menglei,Ni, Jen-Shyang,Li, Yaxi,&Li, Kai.(2021).Monitoring tumor growth with a novel NIR-II photoacoustic probe.Methods in Enzymology,657.

Zha, Menglei,et al."Monitoring tumor growth with a novel NIR-II photoacoustic probe".Methods in Enzymology 657(2021).