Assessing the development and treatment of rheumatoid arthritis using multiparametric photoacoustic and ultrasound imaging

Guo, Heng1,2; Wang, Qin3; Qi, Weizhi2; Sun, Xun3; Ke, Bowen4; Xi, Lei1,2

2019-07-23

10.1002/jbio.201900127

Journal of Biophotonics   影响因子和分区

1864-063X

1864-0648

Rheumatoid arthritis (RA), characterized by polyarthritis, is a chronic, systemic and inflammatory autoimmune disease. In this study, we developed a dual-modality multiparametric photoacoustic and ultrasound imaging technique, and successfully derived multiple parameters such as relative concentration of total hemoglobin (C-HbT), ratio of angiogenesis, joint size and area of synovia to assess the development and treatment of RA. We established a model of adjuvant arthritis using a total number of 15 rats and randomly divided them into three groups: (a) targeted group in which the rats received targeted antirheumatic drugs; (b) nontargeted group in which the rats were treated with nontargeted antirheumatic drugs; (c) control group. We longitudinally monitored the joints of the rats in all three groups for up to 20 days and carried out quantitative analysis to evaluate the development and treatment of RA based on the derived parameters. The results suggest that the proposed dual-modality imaging technique is able to assess the effectiveness of the RA treatment using quantitative hemodynamic and morphological parameters. To show the clinical feasibility of this technique, we performed in vivo joint studies of health volunteers to visualize both structures and inside hemodynamics of the distal interphalangeal joint.

hemodynamics photoacoustic imaging rheumatoid arthritis ultrasound imaging

SCI ; EI

英语

通讯

1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University[ZY2016101] ; 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University[ZY2016203]

Biochemistry & Molecular Biology ; Biophysics ; Optics

Biochemical Research Methods ; Biophysics ; Optics

WOS:000478534200001

WILEY-V C H VERLAG GMBH

20193107257286

Hemodynamics ; Rats ; Ultrasonic imaging

Biomedical Engineering:461.1

Web of Science

1.Univ Elect Sci & Technol China, Sch Phys, Chengdu 610054, Sichuan, Peoples R China
2.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen, Peoples R China
3.Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Minist Educ, Chengdu, Sichuan, Peoples R China
4.Sichuan Univ, West China Hosp, Translat Neurosci Ctr, Lab Anesthesiol & Crit Care Med, Chengdu 610041, Sichuan, Peoples R China

Guo, Heng,Wang, Qin,Qi, Weizhi,et al. Assessing the development and treatment of rheumatoid arthritis using multiparametric photoacoustic and ultrasound imaging[J]. Journal of Biophotonics,2019,12(11).

Guo, Heng,Wang, Qin,Qi, Weizhi,Sun, Xun,Ke, Bowen,&Xi, Lei.(2019).Assessing the development and treatment of rheumatoid arthritis using multiparametric photoacoustic and ultrasound imaging.Journal of Biophotonics,12(11).

Guo, Heng,et al."Assessing the development and treatment of rheumatoid arthritis using multiparametric photoacoustic and ultrasound imaging".Journal of Biophotonics 12.11(2019).