All-in-One Photoacoustic Theranostics Using Multi-Functional Nanoparticles

Li, Tingting; Guo, Heng; Liu, Ye; Qi, Weizhi; Wu, Changfeng; Xi, Lei

2021-10-01

10.1002/adfm.202107624

ADVANCED FUNCTIONAL MATERIALS   影响因子和分区

1616-301X

1616-3028

Both treatment and postoperative evaluation of cancer play vital roles in improving the survival rate of patients. However, existing cancer therapies face multiple challenges of low drug delivery efficiency, separation of treatment and evaluation, and lack of noninvasive, routine and cost-efficient postoperative monitoring methods. To overcome these issues, an all-in-one anti-cancer strategy is proposed by using the combination of the photoacoustic (PA) effect and polymer nanoparticles. This strategy shows enhanced nanoparticles delivery, significant tumor ablation, and the capability of non-invasive and longitudinal postoperative evaluation. Near-infrared (NIR) excited photoacoustic radiation force (PAF) based on the high optical absorption nanoparticles opens the vascular barrier, accumulates the nanoparticles inside the tumor, and enables visualization of real-time nanoparticles distribution. Instead of conventional thermal therapy by using a continuous wave laser, the NIR pulsed laser coupled with PAF offers thermal therapy with further positive accumulation of nanoparticles, and significantly improves the treatment efficiency in return. In addition, the endogenous hemoglobin enables PA imaging to evaluate the efficacy of tumor therapy and monitor the progress of postoperative tumors in vivo through structural and functional parameters of the vascular network. This study presents a new opportunity for formulation of personalized and accurate tumor therapy, and timely feedback of therapeutic effect.

nanoparticles delivery photoacoustic theranostics pulsed laser tumor therapy

SCI ; EI

英语

NI论文

第一 ; 通讯

National Natural Science Foundation of China[62022037,61775028,81571722,61528401] ; Department of Science and Technology of Guangdong Province["2019ZT08Y191","SZBL2020090501013"] ; Shenzhen Science and Technology Program["KQTD20190929172743294","JCYJ20200109141222892"]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000711444600001

WILEY-V C H VERLAG GMBH

20214411101412

Continuous wave lasers ; Controlled drug delivery ; Diseases ; Efficiency ; Infrared devices ; Infrared lasers ; Photoacoustic effect ; Pulsed lasers ; Targeted drug delivery ; Tumors

Biological Materials and Tissue Engineering:461.2 ; Light/Optics:741.1 ; Lasers, General:744.1 ; Acoustic Waves:751.1 ; Nanotechnology:761 ; Production Engineering:913.1 ; Solid State Physics:933

MATERIALS SCIENCE

Web of Science

Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China

Li, Tingting,Guo, Heng,Liu, Ye,et al. All-in-One Photoacoustic Theranostics Using Multi-Functional Nanoparticles[J]. ADVANCED FUNCTIONAL MATERIALS,2021,32.

Li, Tingting,Guo, Heng,Liu, Ye,Qi, Weizhi,Wu, Changfeng,&Xi, Lei.(2021).All-in-One Photoacoustic Theranostics Using Multi-Functional Nanoparticles.ADVANCED FUNCTIONAL MATERIALS,32.

Li, Tingting,et al."All-in-One Photoacoustic Theranostics Using Multi-Functional Nanoparticles".ADVANCED FUNCTIONAL MATERIALS 32(2021).