Insulin-like growth factor-1 in articular cartilage repair for osteoarthritis treatment

Wen，Caining1; Xu，Limei1; Xu，Xiao1; Wang，Daping1,2; Liang，Yujie1,3; Duan，Li1

2021-12-01

10.1186/s13075-021-02662-0

Arthritis Research and Therapy   影响因子和分区

1478-6354

1478-6362

Articular cartilage repair is a critical issue in osteoarthritis (OA) treatment. The insulin-like growth factor (IGF) signaling pathway has been implicated in articular cartilage repair. IGF-1 is a member of a family of growth factors that are structurally closely related to pro-insulin and can promote chondrocyte proliferation, enhance matrix production, and inhibit chondrocyte apoptosis. Here, we reviewed the role of IGF-1 in cartilage anabolism and catabolism. Moreover, we discussed the potential role of IGF-1 in OA treatment. Of note, we summarized the recent progress on IGF delivery systems. Optimization of IGF delivery systems will facilitate treatment application in cartilage repair and improve OA treatment efficacy.

Cartilage repair Chondrocytes IGF-1 Osteoarthritis

SCI

英语

其他

National Natural Science Foundation of China[81972116,81772394,82102607] ; Guangdong International Cooperation Project[2021A0505030011] ; Key Program of Natural Science Foundation of Guangdong Province[2018B0303110003] ; Shenzhen Science and Technology Projects["GJHZ20200731095606019","JCYJ20170817172023838","JCYJ20170413161649437"] ; China Postdoctoral Science Foundation[2020 M682907]

Rheumatology

Rheumatology

WOS:000712958600001

BMC

CLINICAL MEDICINE

2-s2.0-85118297933

Scopus

1.Department of Orthopedics,Guangdong Provincial Research Center for Artificial Intelligence and Digital Orthopedic Technology,Shenzhen Second People’s Hospital,The First Affiliated Hospital of Shenzhen University,Shenzhen,518035,China
2.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China
3.Department of Child and Adolescent Psychiatry,Shenzhen Kangning Hospital,Shenzhen Mental Health Center,Shenzhen,518003,China

Wen，Caining,Xu，Limei,Xu，Xiao,et al. Insulin-like growth factor-1 in articular cartilage repair for osteoarthritis treatment[J]. Arthritis Research and Therapy,2021,23(1).

Wen，Caining,Xu，Limei,Xu，Xiao,Wang，Daping,Liang，Yujie,&Duan，Li.(2021).Insulin-like growth factor-1 in articular cartilage repair for osteoarthritis treatment.Arthritis Research and Therapy,23(1).

Wen，Caining,et al."Insulin-like growth factor-1 in articular cartilage repair for osteoarthritis treatment".Arthritis Research and Therapy 23.1(2021).