Perspectives on mirnas targeting dkk1 for developing hair regeneration therapy

Papukashvili，Dimitri; Rcheulishvili，Nino; Liu，Cong; Xie，Fengfei; Tyagi，Deependra; He，Yunjiao; Wang，Peng George

2021-11-01

10.3390/cells10112957

Cells   影响因子和分区

2073-4409

Androgenetic alopecia (AGA) remains an unsolved problem for the well-being of humankind, although multiple important involvements in hair growth have been discovered. Up until now, there is no ideal therapy in clinical practice in terms of efficacy and safety. Ultimately, there is a strong need for developing a feasible remedy for preventing and treating AGA. The Wnt/β-catenin signaling pathway is critical in hair restoration. Thus, AGA treatment via modulating this pathway is rational, although challenging. Dickkopf-related protein 1 (DKK1) is distinctly identified as an inhibitor of canonical Wnt/β-catenin signaling. Thus, in order to stimulate the Wnt/β-catenin signaling pathway, inhibition of DKK1 is greatly demanding. Studying DKK1-targeting microRNAs (miRNAs) involved in the Wnt/β-catenin signaling pathway may lay the groundwork for the promotion of hair growth. Bearing in mind that DKK1 inhibition in the balding scalp of AGA certainly makes sense, this review sheds light on the perspectives of miRNA-mediated hair growth for treating AGA via regulating DKK1 and, eventually, modulating Wnt/β-catenin signaling. Consequently, certain miRNAs regulating the Wnt/β-catenin signaling pathway via DKK1 inhibition might represent attractive candidates for further studies focusing on promoting hair growth and AGA therapy.

AGA DKK1 Hair MiRNA Wnt/β-catenin

SCI

英语

第一 ; 通讯

Department of Education of Guangdong Province Research Project[2020KZDZX1181] ; Shenzhen Science and Technology Program[KQTD20200909113758004]

Cell Biology

Cell Biology

WOS:000725269200001

MDPI

2-s2.0-85118218359

Scopus

School of Medicine,Southern University of Science and Technology,Shenzhen,518000,China

Papukashvili，Dimitri,Rcheulishvili，Nino,Liu，Cong,et al. Perspectives on mirnas targeting dkk1 for developing hair regeneration therapy[J]. Cells,2021,10(11).

Papukashvili，Dimitri.,Rcheulishvili，Nino.,Liu，Cong.,Xie，Fengfei.,Tyagi，Deependra.,...&Wang，Peng George.(2021).Perspectives on mirnas targeting dkk1 for developing hair regeneration therapy.Cells,10(11).

Papukashvili，Dimitri,et al."Perspectives on mirnas targeting dkk1 for developing hair regeneration therapy".Cells 10.11(2021).