Reducing catheter-associated complications using 4% sodium citrate versus sodium heparin as a catheter lock solution

Huang, He-ming1,2; Jiang, Xin1,2; Meng, Ling-bing3; Di, Chen-yi4; Guo, Peng5; Qiu, Yong6; Dai, Ya-lun7; Lv, Xian-qiang8; Shi, Chang-jin8

2019-07-15

10.1177/0300060519859143

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH   影响因子和分区

0300-0605

1473-2300

Objective Use of a catheter lock solution plays a decisive role in vascular access. The effects of different concentrations of heparin and different types of catheter lock solutions are controversial. Therefore, this study aimed to compare the efficacy and safety of sodium citrate and sodium heparin catheter lock solutions. Methods A total of 120 patients were divided into four groups (30 patients per group) according to the use of catheter lock solution as follows: 6250 U/mL sodium heparin, 5000 U/mL sodium heparin, 2500 U/mL sodium heparin, and 4% sodium citrate. Coagulation function and the incidence of catheter occlusion, hemorrhage, and catheter-related infections were recorded. Results The different catheter lock solutions were significantly related to conduit blockage, hemorrhage, infection, and leakage levels. In the 4% sodium citrate group, the odds ratio was 0.688 for conduit blockage (95% confidence interval [CI], 0.206-2.297), 0.286 for hemorrhage (95% CI, 0.091-0.899), 0.266 for infection (95% CI, 0.073-0.964), and 0.416 for leakage (95% CI, 0.141-1.225) compared with the 6250 U/mL sodium heparin. Conclusions The solution 4% sodium citrate can effectively reduce the risk of catheter obstruction, bleeding, infection, and leakage better than sodium heparin in patients with long-term intravenous indwelling catheters.

Hemodialysis sodium heparin sodium citrate vascular access catheter lock solution hemorrhage infection

SCI

英语

其他

Research & Experimental Medicine ; Pharmacology & Pharmacy

Medicine, Research & Experimental ; Pharmacology & Pharmacy

WOS:000479567000001

SAGE PUBLICATIONS LTD

CLINICAL MEDICINE

Web of Science

1.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Dept Geriatr, Guangzhou, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Guangdong, Peoples R China
3.Hebei Med Univ, Sch Basic Med Sci, Shijiazhuang, Hebei, Peoples R China
4.Peking Univ, Sch Basic Med, Beijing, Peoples R China
5.Hebei Med Univ, Dept Orthoped, Hosp 4, Shijiazhuang, Hebei, Peoples R China
6.Natl Ctr Gerontol, Beijing Hosp, Dept Anesthesiol, Beijing, Peoples R China
7.Natl Ctr Gerontol, Beijing Hosp, Dept Epidemiol, Beijing, Peoples R China
8.Hebei Med Univ, Hosp 4, Dept Urinary Surg, Shijiazhuang 050011, Hebei, Peoples R China

Huang, He-ming,Jiang, Xin,Meng, Ling-bing,et al. Reducing catheter-associated complications using 4% sodium citrate versus sodium heparin as a catheter lock solution[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2019,47(9):4204-4214.

Huang, He-ming.,Jiang, Xin.,Meng, Ling-bing.,Di, Chen-yi.,Guo, Peng.,...&Shi, Chang-jin.(2019).Reducing catheter-associated complications using 4% sodium citrate versus sodium heparin as a catheter lock solution.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,47(9),4204-4214.

Huang, He-ming,et al."Reducing catheter-associated complications using 4% sodium citrate versus sodium heparin as a catheter lock solution".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 47.9(2019):4204-4214.