An anti-interference fluorescent probe for point-of-care diagnosis of albuminuria

Zhao, Xiongfei1; Zheng, Weidong2; Qin, Tianyi1; Du, Xinfeng3; Lei, Yanmei2; Lv, Taoyuze1; Zhou, Mei1; Xu, Zhongyong1; Wang, Lei1; Liu, Bin1; Peng, Xiaojun1,4

2022-01-15

10.1016/j.snb.2021.130980

SENSORS AND ACTUATORS B-CHEMICAL   影响因子和分区

0925-4005

Determination of albuminuria at the point-of-care can provide an early diagnosis and monitor the quality management of numerous diseases. Yet for most fluorescent probes, the detection accuracy is not reliable, since urine itself exhibits very strong endogenous fluorescence causing a considerable interference on response signal. We herein report a novel fluorescent probe DNC with an enhanced environmental sensitivity and red-shifted wavelength (> 600 nm) by enlarging its transition dipole moment. The DNC could selectively bind with drug sites of albumin, causing a significant fluorescence enhancement without the interference from urinary fluorescence. Based on this sensing approach, albuminuria could be directly diagnosed at the point-of-care by using a simple homemade test system (even by naked eyes) without complicate pretreatment of urine.

Fluorescent probes Albumin Albuminuria Point-of-care Transition dipole moment Anti-interference

SCI ; EI

英语

其他

National Natural Science Foundation of China[22077084,32102243] ; Guangdong Basic and Applied Basic Research Foundation[2020A1515011564] ; Natural Science Foundation of Shenzhen University General Hospital[SUGH2018QD027] ; Postdoctoral Science Foundation of China[2021M691084]

Chemistry ; Electrochemistry ; Instruments & Instrumentation

Chemistry, Analytical ; Electrochemistry ; Instruments & Instrumentation

WOS:000714412400006

ELSEVIER SCIENCE SA

20221311863082

Dipole moment ; Fluorescence ; Probes ; Quality management

Light/Optics:741.1 ; Optical Devices and Systems:741.3 ; Physical Chemistry:801.4 ; Management:912.2 ; Optical Instruments:941.3 ; Optical Variables Measurements:941.4

CHEMISTRY

Web of Science

1.Coll Mat Sci & Engn, Guangdong Res Ctr Interfacial Engn Funct Mat, Shenzhen, Peoples R China
2.Shenzhen Univ, Shenzhen Univ Gen Hosp, Dept Lab Med, Shenzhen 518060, Peoples R China
3.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Peoples R China
4.Dalian Univ Technol, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China

Zhao, Xiongfei,Zheng, Weidong,Qin, Tianyi,et al. An anti-interference fluorescent probe for point-of-care diagnosis of albuminuria[J]. SENSORS AND ACTUATORS B-CHEMICAL,2022,351.

Zhao, Xiongfei.,Zheng, Weidong.,Qin, Tianyi.,Du, Xinfeng.,Lei, Yanmei.,...&Peng, Xiaojun.(2022).An anti-interference fluorescent probe for point-of-care diagnosis of albuminuria.SENSORS AND ACTUATORS B-CHEMICAL,351.

Zhao, Xiongfei,et al."An anti-interference fluorescent probe for point-of-care diagnosis of albuminuria".SENSORS AND ACTUATORS B-CHEMICAL 351(2022).