Synthesis of 1,4,5,6-tetrahydropyridazines and pyridazines via transition-metal-free (4+2) cycloaddition of alkoxyallenes with 1,2-diaza-1,3-dienes

Wu, Qi1; Shao, Pan-Lin1,2; He, Yun1

2019-07-10

10.1039/c9ra02712b

RSC Advances   影响因子和分区

2046-2069

We developed an economical and practical protocol for the synthesis of 1,4,5,6-tetrahydropyridazines. A diverse range of alkoxyallenes and 1,2-diaza-1,3-dienes undergo (4 + 2) cycloaddition to generate the desired products in excellent yields. The high efficiency, wide substrate scope and good functional group tolerance of this process, coupled with operational simplicity, render the method synthetically attractive. The utility of the cycloaddition is also demonstrated by the preparation of various pyridazines from 1,4,5,6-tetrahydropyridazines.

SCI ; EI

英语

通讯

National Natural Science Foundation of China[21402150] ; National Natural Science Foundation of China[21572027]

Chemistry

Chemistry, Multidisciplinary

WOS:000475483100051

ROYAL SOC CHEMISTRY

20192907207672

Transition metals

Metallurgy and Metallography:531

Web of Science

1.Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, 55 Daxuecheng South Rd, Chongqing 401331, Peoples R China
2.Southern Univ Sci & Technol, Coll Innovat & Entrepreneurship, Shenzhen 518000, Peoples R China

Wu, Qi,Shao, Pan-Lin,He, Yun. Synthesis of 1,4,5,6-tetrahydropyridazines and pyridazines via transition-metal-free (4+2) cycloaddition of alkoxyallenes with 1,2-diaza-1,3-dienes[J]. RSC Advances,2019,9(37):21507-21512.

Wu, Qi,Shao, Pan-Lin,&He, Yun.(2019).Synthesis of 1,4,5,6-tetrahydropyridazines and pyridazines via transition-metal-free (4+2) cycloaddition of alkoxyallenes with 1,2-diaza-1,3-dienes.RSC Advances,9(37),21507-21512.

Wu, Qi,et al."Synthesis of 1,4,5,6-tetrahydropyridazines and pyridazines via transition-metal-free (4+2) cycloaddition of alkoxyallenes with 1,2-diaza-1,3-dienes".RSC Advances 9.37(2019):21507-21512.