Consistency in Geometry Among Coronary Atherosclerotic Plaques Extracted From Computed Tomography Angiography

Liu, Haipeng1,2; Wingert, Aleksandra2; Wang, Xinhong3; Zhang, Jucheng4; Sun, Jianzhong3; Chen, Fei5; Khalid, Syed Ghufran1,6; Gong, Yinglan7; Xia, Ling7; Jiang, Jun8; Wang, Jian'an8; Zheng, Dingchang1

2021-10-12

10.3389/fphys.2021.715265

Frontiers in Physiology   影响因子和分区

1664-042X

["Background: The three-dimensional (3D) geometry of coronary atherosclerotic plaques is associated with plaque growth and the occurrence of coronary artery disease. However, there is a lack of studies on the 3D geometric properties of coronary plaques. We aim to investigate if coronary plaques of different sizes are consistent in geometric properties.

","Methods: Nineteen cases with symptomatic stenosis caused by atherosclerotic plaques in the left coronary artery were included. Based on attenuation values on computed tomography angiography images, coronary atherosclerotic plaques and calcifications were identified, 3D reconstructed, and manually revised. Multidimensional geometric parameters were measured on the 3D models of plaques and calcifications. Linear and non-linear (i.e., power function) fittings were used to investigate the relationship between multidimensional geometric parameters (length, surface area, volume, etc.). Pearson correlation coefficient (r), R-squared, and p-values were used to evaluate the significance of the relationship. The analysis was performed based on cases and plaques, respectively. Significant linear relationship was defined as R-squared > 0.25 and p < 0.05.

","Results: In total, 49 atherosclerotic plaques and 56 calcifications were extracted. In the case-based analysis, significant linear relationships were found between number of plaques and number of calcifications (r = 0.650, p = 0.003) as well as total volume of plaques (r = 0.538, p = 0.018), between number of calcifications and total volume of plaques (r = 0.703, p = 0.001) as well as total volume of calcification (r = 0.646, p = 0.003), and between the total volumes of plaques and calcifications (r = 0.872, p < 0.001). In plaque-based analysis, the power function showed higher R-squared values than the linear function in fitting the relationships of multidimensional geometric parameters. Two presumptions of plaque geometry in different growth stages were proposed with simplified geometric models developed. In the proposed models, the exponents in the power functions of geometric parameters were in accordance with the fitted values.

","Conclusion: In patients with coronary artery disease, coronary plaques and calcifications are positively related in number and volume. Different coronary plaques are consistent in the relationship between geometry parameters in different dimensions.

"]

coronary artery disease atherosclerotic plaques computed tomography (CT) three-dimensional reconstruction plaque morphology

SCI

英语

其他

Physiology

Physiology

WOS:000713222500001

FRONTIERS MEDIA SA

Web of Science

1.Coventry Univ, Res Ctr Intelligent Healthcare, Coventry, W Midlands, England
2.Anglia Ruskin Univ, Fac Hlth Educ Med & Social Care, Chelmsford, Essex, England
3.Zhejiang Univ, Affiliated Hosp 2, Dept Radiol, Sch Med, Hangzhou, Peoples R China
4.Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Clin Engn, Hangzhou, Peoples R China
5.Southern Univ Sci & Technol, Dept Elect & Elect Engn, Shenzhen, Peoples R China
6.Guys & St Thomas NHS Fdn Trust, Dept Med Phys, London, England
7.Zhejiang Univ, Inst Biomed Engn, Key Lab Biomed Engn, Minist Educ, Hangzhou, Peoples R China
8.Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Cardiol, Hangzhou, Peoples R China

Liu, Haipeng,Wingert, Aleksandra,Wang, Xinhong,et al. Consistency in Geometry Among Coronary Atherosclerotic Plaques Extracted From Computed Tomography Angiography[J]. Frontiers in Physiology,2021,12.

Liu, Haipeng.,Wingert, Aleksandra.,Wang, Xinhong.,Zhang, Jucheng.,Sun, Jianzhong.,...&Zheng, Dingchang.(2021).Consistency in Geometry Among Coronary Atherosclerotic Plaques Extracted From Computed Tomography Angiography.Frontiers in Physiology,12.

Liu, Haipeng,et al."Consistency in Geometry Among Coronary Atherosclerotic Plaques Extracted From Computed Tomography Angiography".Frontiers in Physiology 12(2021).