RNA methylation and cancer treatment

Yang，Baochen1,2,3; Wang，Jing Quan4; Tan，Yao5; Yuan，Runzhu6; Chen，Zhe Sheng4; Zou，Chang1,7,8

2021-12-01

10.1016/j.phrs.2021.105937

PHARMACOLOGICAL RESEARCH   影响因子和分区

1043-6618

1096-1186

To this date, over 100 different types of RNA modification have been identified. Methylation of different RNA species has emerged as a critical regulator of transcript expression. RNA methylation and its related downstream signaling pathways are involved in plethora biological processes, including cell differentiation, sex determination and stress response, and others. It is catalyzed by the RNA methyltransferases, is demethylated by the demethylases (FTO and ALKBH5) and read by methylation binding protein (YTHDF1 and IGF2BP1). Increasing evidence indicates that this process closely connected to cancer cell proliferation, cellular stress, metastasis, immune response. And RNA methylation related protein has been becoming a promising targets of cancer therapy. This review outlines the relationship between different types of RNA methylation and cancer, and some FTO inhibitors in cancer treatment.

5-methylcytosine (PubChem CID: 65040) Azacytidine (PubChem CID: 9444) Cancer therapy Chemical compounds studied in this article N6-methyl-adenosine (PubChem CID: 90474015) Daunorubicin (PubChem CID: 30323) Decitabine (PubChem CID: 451668) FTO inhibitor m6A methylation Meclofenamic acid (PubChem CID: 4037) N1-methyladenosine (PubChem CID: 27476) N3-methylcytosine (PubChem CID: 140523) N7-methylguanosine (PubChem CID: 6474236) Rhein (PubChem CID: 10168) Rhubarb (PubChem CID: 11980951) RNA methylase inhibitor RNA methylation

英语

第一 ; 通讯

PHARMACOLOGY & TOXICOLOGY

2-s2.0-85118512855

Scopus

1.Department of Clinical Medical Research Center,The Second Clinical Medical College,Jinan University (Shenzhen People's Hospital),The First Affiliated Hospital of Southern University of Science and Technology,Shenzhen,China
2.University of Science and Technology,Shenzhen,China
3.Integrated Chinese and Western Medicine Postdoctoral Research Station,Jinan University,Guangzhou,China
4.Department of Pharmaceutical Sciences,College of Pharmacy and Health Sciences,St. John's University,Queens,New York,United States
5.Shenzhen Aier Eye Hospital Affiliated to Jinan University,Shenzhen,China
6.Department of Biology,School of Medicine,Southern University of Science and Technology,Shenzhen,China
7.Shenzhen Public Service Platform on Tumor Precision Medicine and Molecular Diagnosis,The Second Clinical Medical College,Jinan University (Shenzhen People's Hospital),Shenzhen,China
8.School of Life and Health Sciences,The Chinese University of Kong Hong,Shenzhen,China

Yang，Baochen,Wang，Jing Quan,Tan，Yao,et al. RNA methylation and cancer treatment[J]. PHARMACOLOGICAL RESEARCH,2021,174.

Yang，Baochen,Wang，Jing Quan,Tan，Yao,Yuan，Runzhu,Chen，Zhe Sheng,&Zou，Chang.(2021).RNA methylation and cancer treatment.PHARMACOLOGICAL RESEARCH,174.

Yang，Baochen,et al."RNA methylation and cancer treatment".PHARMACOLOGICAL RESEARCH 174(2021).