Role of Corticotropin Releasing Factor in the Neuroimmune Mechanisms of Depression: Examination of Current Pharmaceutical and Herbal Therapies

Jiang, Yizhou1,2,3; Peng, Tangming1,2,4,5; Gaur, Uma1,2; Silva, Marta1,2; Little, Peter6; Chen, Zhong7; Qiu, Wei8; Zhang, Yandong3; Zheng, Wenhua1,2

2019-07-02

10.3389/fncel.2019.00290

Frontiers in Cellular Neuroscience   影响因子和分区

1662-5102

Approximately 3% of the world population suffers from depression, which is one of the most common form of mental disorder. Recent findings suggest that an interaction between the nervous system and immune system might be behind the pathophysiology of various neurological and psychiatric disorders, including depression. Neuropeptides have been shown to play a major role in mediating response to stress and inducing immune activation or suppression. Corticotropin releasing factor (CRF) is a major regulator of the hypothalamic pituitary adrenal (HPA) axis response. CRF is a stress-related neuropeptide whose dysregulation has been associated with depression. In this review, we summarized the role of CRF in the neuroimmune mechanisms of depression, and the potential therapeutic effects of Chinese herbal medicines (CHM) as well as other agents. Studying the network of CRF and immune responses will help to enhance our understanding of the pathogenesis of depression. Additionally, targeting this important network may aid in developing novel treatments for this debilitating psychiatric disorder.

depression neuroimmune system corticotropin releasing factor HPA axis stress

SCI ; SSCI

英语

通讯

Science and Technology Development Fund (FDCT) of Macao[016/2016/A1] ; Science and Technology Development Fund (FDCT) of Macao[0113/2018/A3]

Neurosciences & Neurology

Neurosciences

WOS:000473706100001

FRONTIERS MEDIA SA

Web of Science

1.Univ Macau, Ctr Reprod Dev & Aging, Macau, Peoples R China
2.Univ Macau, Inst Translat Med, Fac Hlth Sci, Macau, Peoples R China
3.Southern Univ Sci & Technol, Dept Biol, Shenzhen, Peoples R China
4.Southwest Med Univ, Affiliated Hosp, Dept Neurosurg, Luzhou, Peoples R China
5.Neurosurg Clin Res Ctr Sichuan Prov, Luzhou, Peoples R China
6.Univ Queensland, Pharm Australia Ctr Excellence, Sch Pharm, Woolloongabba, Qld, Australia
7.Zhejiang Univ, Inst Pharmacol & Toxicol, Coll Pharmaceut Sci, Key Lab Med Neurobiol,Minist Hlth China, Hangzhou, Zhejiang, Peoples R China
8.Sun Yat Sen Univ, Affiliated Hosp 3, Guangzhou, Guangdong, Peoples R China

Jiang, Yizhou,Peng, Tangming,Gaur, Uma,et al. Role of Corticotropin Releasing Factor in the Neuroimmune Mechanisms of Depression: Examination of Current Pharmaceutical and Herbal Therapies[J]. Frontiers in Cellular Neuroscience,2019,13.

Jiang, Yizhou.,Peng, Tangming.,Gaur, Uma.,Silva, Marta.,Little, Peter.,...&Zheng, Wenhua.(2019).Role of Corticotropin Releasing Factor in the Neuroimmune Mechanisms of Depression: Examination of Current Pharmaceutical and Herbal Therapies.Frontiers in Cellular Neuroscience,13.

Jiang, Yizhou,et al."Role of Corticotropin Releasing Factor in the Neuroimmune Mechanisms of Depression: Examination of Current Pharmaceutical and Herbal Therapies".Frontiers in Cellular Neuroscience 13(2019).