题名 | Validation of NEDD8-conjugating enzyme UBC12 as a new therapeutic target in lung cancer |
作者 | |
通讯作者 | Jia, Lijun |
发表日期 | 2019-07
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DOI | |
发表期刊 | |
ISSN | 2352-3964
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卷号 | 45页码:81-91 |
摘要 | Background: The neddylation pathway is overactivated in human cancers. Inhibition of neddylation pathway has emerged as an attractive anticancer strategy. The mechanisms underlying neddylation overactivation in cancer remain elusive. MLN4924/Pevonedistat, a first-in-class NEDD8-activating enzyme (NAE, E1) inhibitor, exerts significant anti-tumor effects, but its mutagenic resistance remains unresolved. |
关键词 | |
相关链接 | [来源记录] |
收录类别 | |
语种 | 英语
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学校署名 | 其他
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资助项目 | National Thirteenth Five-Year Science and Technology Major Special Project for New Drug and Development[2017ZX09304001]
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WOS研究方向 | General & Internal Medicine
; Research & Experimental Medicine
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WOS类目 | Medicine, General & Internal
; Medicine, Research & Experimental
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WOS记录号 | WOS:000475860000018
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出版者 | |
来源库 | Web of Science
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引用统计 |
被引频次[WOS]:48
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成果类型 | 期刊论文 |
条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/25594 |
专题 | 南方科技大学医学院 |
作者单位 | 1.Shanghai Univ Tradit Chinese Med, Longhua Hosp, Canc Inst Tradit Chinese Med, Shanghai, Peoples R China 2.Fudan Univ, Shanghai Canc Ctr, Canc Inst, Shanghai, Peoples R China 3.Fudan Univ, Huadong Hosp, Dept Lab Med, Shanghai, Peoples R China 4.Zhejiang Chinese Med Univ, Zhejiang Prov Hosp Tradit Chinese Med, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China 5.Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China 6.Shanghai Jiao Tong Univ, Xinhua Hosp, Shanghai, Peoples R China |
推荐引用方式 GB/T 7714 |
Li, Lihui,Kang, Jihui,Zhang, Wenjuan,et al. Validation of NEDD8-conjugating enzyme UBC12 as a new therapeutic target in lung cancer[J]. EBioMedicine,2019,45:81-91.
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APA |
Li, Lihui.,Kang, Jihui.,Zhang, Wenjuan.,Cai, Lili.,Wang, Shiwen.,...&Jia, Lijun.(2019).Validation of NEDD8-conjugating enzyme UBC12 as a new therapeutic target in lung cancer.EBioMedicine,45,81-91.
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MLA |
Li, Lihui,et al."Validation of NEDD8-conjugating enzyme UBC12 as a new therapeutic target in lung cancer".EBioMedicine 45(2019):81-91.
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条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | 操作 | |
paper2019-4.pdf(3927KB) | -- | -- | 开放获取 | -- | 浏览 |
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