| 题名 | Role of IL-37 in Cardiovascular Disease Inflammation |
| 作者 | |
| 通讯作者 | Dong, Ming |
| 发表日期 | 2019-07
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| DOI | |
| 发表期刊 | |
| ISSN | 0828-282X
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| EISSN | 1916-7075
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| 卷号 | 35期号:7页码:923-930 |
| 摘要 | Inflammation is closely related to the pathogenesis and prognosis of cardiovascular disease (CVD). Interleukin-37 (IL-37), an antiinflammatory IL-1 family cytokine, shifts cytokine expression from pro-to anti-inflammation via regulation of macrophage polarization and lipid metabolism. In macrophages, IL-37 functions through both intracellular and extracellular pathways to regulate the activity of NF-kappa B and PTEN as well as the expression of cytokines, including IL-1 beta, IL-6, and IL-10. Moreover, IL-37 levels are increased in the serum of patients with heart failure, atherosclerosis, and acute coronary syndrome with no evidence of anti-inflammatory effects. However, transgenic overexpression of IL-37 improves cardiac infarct and attenuates atherosclerosis plaque expansion. Hence, it is worthwhile to investigate the precise mechanism and role of IL-37 in the pathogenesis of CVD, which may provide deeper understanding of the inflammatory response in this context. This review summarizes the regulatory role of IL-37 in systematic inflammation induced by CVD and highlights recent advancements in the clinical application of IL-37 as a therapeutic agent or biomarker for diagnosis of CVD. |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 其他
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| WOS研究方向 | Cardiovascular System & Cardiology
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| WOS类目 | Cardiac & Cardiovascular Systems
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| WOS记录号 | WOS:000474197600021
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| 出版者 | |
| ESI学科分类 | CLINICAL MEDICINE
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| 来源库 | Web of Science
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| 引用统计 |
被引频次[WOS]：25
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/25604 |
| 专题 | 南方科技大学第一附属医院 |
| 作者单位 | 1.Shenzhen Univ, Dept Pathophysiol, Guangdong Key Lab Genome Stabil & Human Dis Preve, Hlth Sci Ctr, Shenzhen, Guangdong, Peoples R China 2.Jinan Univ, Clin Med Coll 2, Dept Endocrinol, Shenzhen Peoples Hosp, Shenzhen, Guangdong, Peoples R China 3.Southern Univ Sci & Technol, Affiliated Hosp 1, Clin Med Res Ctr, Shenzhen, Guangdong, Peoples R China 4.Guangdong Med Coll, Dept Cardiol, Nanshan Hosp, Shenzhen, Guangdong, Peoples R China 5.Guangzhou Med Univ, Dept Cardiol, Shenzhen Shajing Hosp, Shenzhen, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 |
Yang, Ziyi,Kang, Lin,Wang, Yan,et al. Role of IL-37 in Cardiovascular Disease Inflammation[J]. CANADIAN JOURNAL OF CARDIOLOGY,2019,35(7):923-930.
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| APA |
Yang, Ziyi.,Kang, Lin.,Wang, Yan.,Xiang, Jiaqing.,Wu, Qianying.,...&Dong, Ming.(2019).Role of IL-37 in Cardiovascular Disease Inflammation.CANADIAN JOURNAL OF CARDIOLOGY,35(7),923-930.
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| MLA |
Yang, Ziyi,et al."Role of IL-37 in Cardiovascular Disease Inflammation".CANADIAN JOURNAL OF CARDIOLOGY 35.7(2019):923-930.
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| 条目包含的文件 | 条目无相关文件。 | |||||
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