The combined regimens of antiviral therapy might not be useful for the viral clearance of severe COVID-19 cases

Li, Xuan2; Zhou, Liyang1; Zhang, Lina3; Zheng, Shuo1; Huang, Fang4; Pan, Xingfei1; Fang, Wang2

2021-11-01

10.1016/j.jiph.2021.09.020

Journal of Infection and Public Health   影响因子和分区

1876-0341

1876-035X

["Background: Severe COVID-19 caused by SARS-CoV-2 should closely be cared because of the relatively high mortality rate. If SARS-CoV-2 could be cleared as soon as possible, the mortality rate might lower. In the present study, we analyzed factors which might be related to the clearance of SARS-CoV-2.","Methods: One hundred and twenty-eight severe COVID-19 cases were enrolled. All of them had been isolated and treated at Shenzhen Third People's Hospital because they were positive for nucleic acid of SARS-CoV-2 tested by qRT-PCR. Their baseline clinical characteristics and antiviral regimens were collected and analyzed, respectively.","Results: Of the 128 enrolled severe COVID-19 cases, unfortunately 3 died. The mean viral duration of all patients was 23.5 (range 17-32) days. All patients achieved viral clearance during 9 weeks. 13.4% of patients achieved viral clearance within 2 weeks, and 63.0% of patients achieved viral clearance within 4 weeks. The combined regimens of three or more antiviral drugs, the use of invasive mechanical ventilation, and late admission might be related to the delay of viral clearance within 2 weeks. The use of arbidol, the use of invasive mechanical ventilation, and late admission might be related to the delay of viral clearance within 4 weeks. Patients often had a prolonged course of COVID-19 and hospitalization, and were more likely transferred to intensive care unit (ICU) for treatment, if they could not clear SARS-CoV-2 during 23 days.","Conclusion: Severe COVID-19 cases should be admitted to hospital as soon as possible. The combined regimens of three or more antiviral drugs might not be useful for viral clearance, and should be performed carefully and cautiously. (C) 2021 The Author(s). Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences."]

Severe COVID-19 Combined regimens Antiviral therapy SARS-CoV-2

SCI

英语

第一 ; 通讯

National Clinical Research Center for Infectious Diseases, Shenzhen Key Medical Discipline Construction Fund[SZXKO76] ; Sanming Project of Medicine in Shenzhen[SZSM201612014] ; Sino-German Center for Research Promotion (SGC)[C-0032]

Public, Environmental & Occupational Health ; Infectious Diseases

Public, Environmental & Occupational Health ; Infectious Diseases

WOS:000709719100021

ELSEVIER SCIENCE LONDON

Web of Science

1.Guangzhou Med Univ, Affiliated Hosp 3, Dept Infect Dis, Guangzhou, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 2, Shenzhen Peoples Hosp 3, Dept Liver Dis, Shenzhen, Peoples R China
3.Shenzhen Third Peoples Hosp, Clin COVID 19 Pneumonia & Chron Dis Follow Up, Shenzhen, Peoples R China
4.Shenzhen Third Peoples Hosp, Dept Med Serv, Shenzhen, Peoples R China

Li, Xuan,Zhou, Liyang,Zhang, Lina,et al. The combined regimens of antiviral therapy might not be useful for the viral clearance of severe COVID-19 cases[J]. Journal of Infection and Public Health,2021,14(11).

Li, Xuan.,Zhou, Liyang.,Zhang, Lina.,Zheng, Shuo.,Huang, Fang.,...&Fang, Wang.(2021).The combined regimens of antiviral therapy might not be useful for the viral clearance of severe COVID-19 cases.Journal of Infection and Public Health,14(11).

Li, Xuan,et al."The combined regimens of antiviral therapy might not be useful for the viral clearance of severe COVID-19 cases".Journal of Infection and Public Health 14.11(2021).