General Thermodynamic-Controlled Coating Method to Prepare Janus Mesoporous Nanomotors for Improving Tumor Penetration

Chen, Kun1,2,3; Peng, Xin4,5; Dang, Meng1,2; Tao, Jun1,2; Ma, Jingbo3; Li, Zhijie3; Zheng, Liuhai3; Su, Xiaodan1,2; Wang, Lianhui1,2; Teng, Zhaogang1,2,6

2021-11-03

10.1021/acsami.1c11838

ACS Applied Materials & Interfaces   影响因子和分区

1944-8244

1944-8252

Artificial nanomotors are undergoing significant developments in several biomedical applications. However, current experimental strategies for producing nanomotors still have inherent drawbacks such as the requirement for expensive equipment, strict controlling of experimental conditions, and strenuous processes with several complex procedures. In this study, we describe for the first time a facile single-step thermodynamic-controlled coating method to prepare Janus mesoporous organosilica nanomotors. By controlling the total free energy of organosilica oligomers (G) from a low development level to a high level in the reaction system, the nonspontaneous nucleation on the platinum (Pt) nanosurface and the spontaneous nucleation in a solvent can be controlled, respectively. More importantly, we reveal that the molecular arrangement and contact angle of deposited organosilica on Pt cores vary with the total free energy of organosilica oligomers (G). Different values of. would change the trend of detachment from Pt for organosilica nucleated cores and carry out diverse coating modes. These are indicated by the morphology evolution of platinum/ organosilica hybrids, from naked platinum nanoparticles, evenly distributed organosilica shell/core, nonconcentric to typical Janus nanomotor. The prepared Janus mesoporous nanomotor (JMN) showed typical mesopore structures and active propelling behaviors under H2O2 stimulation. In addition, the JMN modified with hyaluronic acid exhibited excellent biocompatibility and improved tumor penetration under H2O2 stimulation. The successful construction of other nanomotor frameworks based on a gold-templated core proves the perfect applicability of the thermodynamic-coating method for the production of nanomotors. In conclusion, this work establishes a manufacturing methodology for nanomotors and drives nanomotors for promising biomedical applications.

nanomotors mesoporous organosilica thermodynamic total free energy tumor penetration

SCI ; EI

英语

通讯

National Natural Science Foundation of China[81971675,21603106] ; Natural Science Foundation of Jiangsu Province[BK20160017] ; State Key Laboratory of Analytical Chemistry for Life Science[5431ZZXM1717] ; Basic and Applied Basic Research Foundation of Guangdong Province[2021A1515012164]

Science & Technology - Other Topics ; Materials Science

Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000715852100063

AMER CHEMICAL SOC

Web of Science

1.Nanjing Univ Posts & Telecommun, Jiangsu Natl Synerget Innovat Ctr Adv Mat, Key Lab Organ Elect & Informat Displays, Nanjing 210046, Jiangsu, Peoples R China
2.Nanjing Univ Posts & Telecommun, Jiangsu Natl Synerget Innovat Ctr Adv Mat, Inst Adv Mat, Jiangsu Key Lab Biosensors, Nanjing 210046, Jiangsu, Peoples R China
3.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Geriatr,Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China
4.Nanjing Univ, Med Sch, Affiliated Nanjing Drum Tower Hosp, Dept Radiol, Nanjing 210008, Peoples R China
5.Southeast Univ, Zhongda Hosp, Sch Med, Dept Radiol, Nanjing 210009, Jiangsu, Peoples R China
6.Nanjing Univ, State Key Lab Analyt Chem Life Sci, Sch Chem & Chem Engn, Nanjing 210093, Jiangsu, Peoples R China

Chen, Kun,Peng, Xin,Dang, Meng,et al. General Thermodynamic-Controlled Coating Method to Prepare Janus Mesoporous Nanomotors for Improving Tumor Penetration[J]. ACS Applied Materials & Interfaces,2021,13(43).

Chen, Kun.,Peng, Xin.,Dang, Meng.,Tao, Jun.,Ma, Jingbo.,...&Teng, Zhaogang.(2021).General Thermodynamic-Controlled Coating Method to Prepare Janus Mesoporous Nanomotors for Improving Tumor Penetration.ACS Applied Materials & Interfaces,13(43).

Chen, Kun,et al."General Thermodynamic-Controlled Coating Method to Prepare Janus Mesoporous Nanomotors for Improving Tumor Penetration".ACS Applied Materials & Interfaces 13.43(2021).