Wearable fluorescent contact lenses for monitoring glucose via a smartphone

Deng，Mengyu; Song，Guangjie; Zhong，Ke; Wang，Zhanchen; Xia，Xi; Tian，Yanqing

2022-02-01

10.1016/j.snb.2021.131067

SENSORS AND ACTUATORS B-CHEMICAL   影响因子和分区

0925-4005

0925-4005

Real-time, continuous and non-invasive glucose monitoring is essential for the health of diabetic. In this work, we developed soft and transparent smart contact lenses which could detect glucose in tear with high sensitivity. The smart contact lenses were prepared by immobilizing a sensitive glucose fluorescent probe and another reference fluorescent dye into the hydrogel network of the contact lenses. With the increase of glucose concentration, the fluorescent color of the smart contact lenses changed from pink to blue. The fluorescent images could be collected by a smartphone and transformed into RGB signals to quantify the glucose levels. These smart contact lenses could successfully monitor glucose level of 23 μM–1.0 mM in tears by a smart phone. The animal experiments further demonstrate the biosafety of smart contact lenses and the potential application of glucose monitoring. The fluorescence sensor platform is expected to be a new method for painless glucose monitoring.

Contact lenses Diabetes Fluorescent sensor Glucose detection Smart hydrogel

SCI ; EI

英语

第一 ; 通讯

National Natural Science Foundation of China[21574061,21774054] ; Shenzhen Fundamental Research Programs["JCYJ20170412152922553","JCYJ20190809120013254"]

Chemistry ; Electrochemistry ; Instruments & Instrumentation

Chemistry, Analytical ; Electrochemistry ; Instruments & Instrumentation

WOS:000721806700007

ELSEVIER SCIENCE SA

20214611165997

Fluorescence ; Glucose ; Hydrogels ; Smartphones ; Wearable sensors

Biomaterials (including synthetics):462.5 ; Telephone Systems and Equipment:718.1 ; Light/Optics:741.1 ; Optical Devices and Systems:741.3 ; Colloid Chemistry:801.3 ; Chemical Products Generally:804 ; Organic Compounds:804.1

CHEMISTRY

2-s2.0-85119014569

Scopus

Department of Materials Science and Engineering,Southern University of Science and Technology,Shenzhen,518055,China

Deng，Mengyu,Song，Guangjie,Zhong，Ke,et al. Wearable fluorescent contact lenses for monitoring glucose via a smartphone[J]. SENSORS AND ACTUATORS B-CHEMICAL,2022,352.

Deng，Mengyu,Song，Guangjie,Zhong，Ke,Wang，Zhanchen,Xia，Xi,&Tian，Yanqing.(2022).Wearable fluorescent contact lenses for monitoring glucose via a smartphone.SENSORS AND ACTUATORS B-CHEMICAL,352.

Deng，Mengyu,et al."Wearable fluorescent contact lenses for monitoring glucose via a smartphone".SENSORS AND ACTUATORS B-CHEMICAL 352(2022).