Association of Predicted Lean Body Mass and Fat Mass With Incident Diabetic Nephropathy in Participants With Type 2 Diabetes Mellitus: A Post Hoc Analysis of ACCORD Trial

Hukportie，Daniel Nyarko1; Li，Fu Rong1,2; Zhou，Rui1; Zou，Meng Chen3; Wu，Xiao Xiang4; Wu，Xian Bo1

2021-10-27

10.3389/fendo.2021.719666

Frontiers in Endocrinology   影响因子和分区

1664-2392

Background: Lean body mass (LBM) and fat mass (FM) have been shown to have different associations with several chronic diseases but little is known about the sex-specific association of LBM and FM with diabetic nephropathy (DN) risk among participants with diabetes. Methods: Participants from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study was used in a post hoc analysis to examine the association of predicted LBM index (LBMI) and FM index (FMI) with incident DN risk (defined as a composite outcome of three types of predefined DN). Because of sex differences in body composition, analyses were conducted separately using sex-specific quartiles of predicted LBMI and FMI. Results: Of the 9,022 participants with type 2 diabetes (5,575 men and 3,447 women) included in this study, 5,374 individuals developed DN (3,396 in men and 1,978 in women). Higher quartiles of LBMI were associated with a reduced risk of DN while higher quartiles of FMI were associated with an increased higher risk of DN among men but not women. Compared with the lowest quartile, the fully adjusted hazard ratios (HRs) and 95% confidence intervals (CIs)for the highest quartile of predicted LBMI and FMI were respectively 0.83 (95% CI 1.71 – 0.96) and 1.23 (95% CI 1.06-1.43) among men; and 0.92 (95% CI 0.63 – 1.33) and 1.14 (95% CI 0.79 – 1.63) among women. Conclusions: Among participants with diabetes, predicted LBMI was inversely associated with risk of DN while predicted FMI was positively associated with an increased risk of incident DN among men but not women. Trial registration: ClinicalTrials.gov., no. NCT00000620.

diabetes diabetic nephropathy fat mass lean body mass obesity

SCI

英语

其他

WOS:000717615100001

2-s2.0-85118802250

Scopus

1.Department of Epidemiology,School of Public Health,Southern Medical University,Guangdong Provincial Key Laboratory of Tropical Disease Research),Guangzhou,China
2.School of Medicine,Southern University of Science and Technology,Shenzhen,China
3.Department of Endocrinology and Metabolism,Nanfang Hospital,Southern Medical University,Guangzhou,China
4.Department of General Surgery,157thHospital,General Hospital of Guangzhou Military Command,Guangzhou,China

Hukportie，Daniel Nyarko,Li，Fu Rong,Zhou，Rui,et al. Association of Predicted Lean Body Mass and Fat Mass With Incident Diabetic Nephropathy in Participants With Type 2 Diabetes Mellitus: A Post Hoc Analysis of ACCORD Trial[J]. Frontiers in Endocrinology,2021,12.

Hukportie，Daniel Nyarko,Li，Fu Rong,Zhou，Rui,Zou，Meng Chen,Wu，Xiao Xiang,&Wu，Xian Bo.(2021).Association of Predicted Lean Body Mass and Fat Mass With Incident Diabetic Nephropathy in Participants With Type 2 Diabetes Mellitus: A Post Hoc Analysis of ACCORD Trial.Frontiers in Endocrinology,12.

Hukportie，Daniel Nyarko,et al."Association of Predicted Lean Body Mass and Fat Mass With Incident Diabetic Nephropathy in Participants With Type 2 Diabetes Mellitus: A Post Hoc Analysis of ACCORD Trial".Frontiers in Endocrinology 12(2021).