Targeting aryl hydrocarbon receptor signaling enhances type i interferon-independent resistance to herpes simplex virus

Chen，Jincheng1,2; Liang，Juan2,3; Xu，Hui2; Liu，Wenqi2; Liu，Shuyan2; Duan，Lian2; Li，Fang2; Wang，Zhaoqin2; Liu，Yingxia2; McSharry，Brian4; Feng，Carl G.4; Zhang，Guoliang2,4

2021-10-01

10.1128/Spectrum.00473-21

Microbiology Spectrum   影响因子和分区

2165-0497

2165-0497

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcript factor that plays an important role in regulating immunity and cell differentiation. However, its role in cell-autonomous antiviral resistance has not been fully elucidated. Here, we show that interruption of AHR signaling in human cells by a chemical antagonist or genetic targeting led to significant reductions in the replication of herpes simplex virus 1 (HSV-1) and cytomegalovirus (CMV), revealing an unexpected proviral function of AHR. Interestingly, the enhanced viral control in the absence of AHR is independent of type I interferon (IFN) signaling. Together, these results reveal a previously unknown function of AHR in promoting viral replication in vitro and suggest a potential intervention point for treating viral disease.

Aryl hydrocarbon receptor Herpes simplex virus 1 Type I interferons Viral replication

SCI

英语

通讯

Natural Science Foundation of China[81873958] ; National Key Research and Development Plan["2020YFA0907200","2019YFC0840602"] ; Guangdong Scientific and Technological Foundation["2019B1515120041","2020B1111170014","2020A1515010977","2019A1515110055"] ; Shenzhen Scientific and Technological Foundation["KCXFZ202002011007083","JSGG20200225150702770"]

Microbiology

Microbiology

WOS:000728629300056

AMER SOC MICROBIOLOGY

2-s2.0-85119159999

Scopus

1.Savaid Medical School,University of Chinese Academy of Sciences,Beijing,China
2.National Clinical Research Center for Infectious Diseases,Guangdong Provincial Clinical Research Center for Tuberculosis,The Third People's Hospital of Shenzhen,Southern University of Science and Technology,Shenzhen,China
3.Biomedical Translational Research Institute,Faculty of Medical Science,Jinan University,Guangzhou,China
4.Infections,Immunity and Inflammation,School of Medical Sciences,Faculty of Medicine and Health,University of Sydney,Sydney,Australia

Chen，Jincheng,Liang，Juan,Xu，Hui,et al. Targeting aryl hydrocarbon receptor signaling enhances type i interferon-independent resistance to herpes simplex virus[J]. Microbiology Spectrum,2021,9(2).

Chen，Jincheng.,Liang，Juan.,Xu，Hui.,Liu，Wenqi.,Liu，Shuyan.,...&Zhang，Guoliang.(2021).Targeting aryl hydrocarbon receptor signaling enhances type i interferon-independent resistance to herpes simplex virus.Microbiology Spectrum,9(2).

Chen，Jincheng,et al."Targeting aryl hydrocarbon receptor signaling enhances type i interferon-independent resistance to herpes simplex virus".Microbiology Spectrum 9.2(2021).