Iron-Catalyzed Photoinduced Remote C(sp3)-H Amination of Free Alcohols

Xiong，Ni1; Li，Yang1; Zeng，Rong1,2

2021

10.1021/acs.orglett.1c03488

ORGANIC LETTERS   影响因子和分区

1523-7060

1523-7052

We report a general photocatalytic protocol for the remote C(sp3)-H bond amination of free aliphatic alcohols. The electron transfer between the abundant and inexpensive catalyst FeCl3 and simple alkanols under blue LED irradiation enables the alkoxy radical formation under mild redox-neutral conditions, with no need for additional oxidant and prefunctionalization. The subsequent selective 1,5-hydrogen atom transfer (HAT) and amination provide a simple and efficient way to access molecular complexity from readily available and bulk alcohols.

SCI

英语

NI期刊

通讯

National Natural Science Foundation of China[21901197] ; Guangdong Provincial Key Laboratory of Catalysis[2020B121201002] ; Natural Science Basic Research Plan in Shaanxi Province of China[2021JM004]

Chemistry

Chemistry, Organic

WOS:000744183900009

AMER CHEMICAL SOC

CHEMISTRY

2-s2.0-85118958630

Scopus

1.School of Chemistry,MOE,Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter,Xi'An Key Laboratory of Sustainable Energy Materials Chemistry,Xi'An Jiaotong University,Xi'an,710049,China
2.Guangdong Provincial Key Laboratory of Catalysis,Southern University of Science and Technology,Guangdong,Shenzhen,518055,China

Xiong，Ni,Li，Yang,Zeng，Rong. Iron-Catalyzed Photoinduced Remote C(sp3)-H Amination of Free Alcohols[J]. ORGANIC LETTERS,2021,23(22).

Xiong，Ni,Li，Yang,&Zeng，Rong.(2021).Iron-Catalyzed Photoinduced Remote C(sp3)-H Amination of Free Alcohols.ORGANIC LETTERS,23(22).

Xiong，Ni,et al."Iron-Catalyzed Photoinduced Remote C(sp3)-H Amination of Free Alcohols".ORGANIC LETTERS 23.22(2021).