南方科技大学知识苑(SUSTech KC): Palladium-Catalyzed Diastereoselective Formal [5+3] Cycloaddition for the Construction of Spirooxindoles Fused with an Eight-Membered Ring

题名	Palladium-Catalyzed Diastereoselective Formal [5+3] Cycloaddition for the Construction of Spirooxindoles Fused with an Eight-Membered Ring
作者	Niu, Ben 1,2; Wu, Xiao-Yun 1,2; Wei, Yin 4; Shi, Min1,2,3,4
通讯作者	Shi, Min
发表日期	2019-06-21
DOI	10.1021/acs.orglett.9b01748
发表期刊	ORGANIC LETTERS 影响因子和分区
ISSN	1523-7060
EISSN	1523-7052
卷号	21 期号:12页码:4859-4863
摘要	A Pd-catalyzed formal [5 + 3] intermolecular cycloaddition reaction of isatin-derived alpha-(trifluoromethyl)-imines with aryl substituted vinylethylene carbonates (VECs) has been reported, affording trifluoromethyl-group-containing spirooxindoles fused with an eight-membered ring as a single diastereoisomer in good yields in the presence of a Bronsted acid in a one-pot manner under mild conditions. The asymmetric version of this reaction has been also realized using a chiral phosphine ligand along with the further transformation of the obtained product to give a spirooxindolo pyrrolidine derivative upon oxidation.
相关链接	[来源记录]
收录类别	SCI ; IC ; CCR
语种	英语
重要成果	NI期刊
学校署名	通讯
资助项目	[sioczz201808]
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
WOS记录号	WOS:000473116000097
出版者	AMER CHEMICAL SOC
ESI学科分类	CHEMISTRY
来源库	Web of Science
引用统计	被引频次[WOS]：69
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/25667
专题	深圳格拉布斯研究院
作者单位	1.East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, 130 Mei Long Rd, Shanghai 200237, Peoples R China 2.East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, 130 Mei Long Rd, Shanghai 200237, Peoples R China 3.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518000, Guangdong, Peoples R China 4.Chinese Acad Sci, Univ Chinese Acad Sci, State Key Lab Organometall Chem, Ctr Excellence Mol Synth,Shanghai Inst Organ Chem, 354 Fenglin Lu, Shanghai 200032, Peoples R China
通讯作者单位	深圳格拉布斯研究院
推荐引用方式 GB/T 7714	Niu, Ben,Wu, Xiao-Yun,Wei, Yin,et al. Palladium-Catalyzed Diastereoselective Formal [5+3] Cycloaddition for the Construction of Spirooxindoles Fused with an Eight-Membered Ring[J]. ORGANIC LETTERS,2019,21(12):4859-4863.
APA	Niu, Ben,Wu, Xiao-Yun,Wei, Yin,&Shi, Min.(2019).Palladium-Catalyzed Diastereoselective Formal [5+3] Cycloaddition for the Construction of Spirooxindoles Fused with an Eight-Membered Ring.ORGANIC LETTERS,21(12),4859-4863.
MLA	Niu, Ben,et al."Palladium-Catalyzed Diastereoselective Formal [5+3] Cycloaddition for the Construction of Spirooxindoles Fused with an Eight-Membered Ring".ORGANIC LETTERS 21.12(2019):4859-4863.