南方科技大学知识苑(SUSTech KC): Efficient Access to Chiral beta-Borylated Carboxylic Esters via Rh-Catalyzed Hydrogenation

题名	Efficient Access to Chiral beta-Borylated Carboxylic Esters via Rh-Catalyzed Hydrogenation
作者	Liu, Gang 1; Li, Anqi 1; Qin, Xueyuan 1; Han, Zhengyu 1; Dong, Xiu-Qin 1; Zhang, Xumu2,3
通讯作者	Dong, Xiu-Qin; Zhang, Xumu
发表日期	2019-06-18
DOI	10.1002/adsc.201900161
发表期刊	ADVANCED SYNTHESIS & CATALYSIS 影响因子和分区
ISSN	1615-4150
EISSN	1615-4169
卷号	361 期号:12页码:2844-2848
摘要	Rh/bisphosphine-thiourea ligand (ZhaoPhos)-catalyzed asymmetric hydrogenation of (Z)-beta-substituted-beta-boryl-alpha,beta-unsaturated esters was successfully developed, furnishing a variety of chiral beta-borylated carboxylic esters with high yields and excellent enantioselectivities (up to 99% yield and > 99% ee). The gram-scale asymmetric hydrogenation was performed efficiently in the presence of only 0.05 mol% (S/C = 2 000) catalyst loading with full conversion, 99% yield and 99% ee. Moreover, the hydrogenation product was easily converted to other versatile synthetic intermediates, such as methyl (S)-3-hydroxy-3-phenylpropanoate and methyl (S)-3-(furan-2-yl)-3-phenylpropanoate.
关键词	Asymmetric hydrogenation chiral beta-borylated carboxylic esters enantioselectivity bisphosphine ligand beta-boryl-alpha,beta-unsaturated esters
相关链接	[来源记录]
收录类别	SCI ; IC ; CCR
语种	英语
学校署名	通讯
资助项目	Science and Technology Innovation Committee of Shenzhen[KQTD20150717103157174] ; Science and Technology Innovation Committee of Shenzhen[JSGG 20170821140353405] ; Science and Technology Innovation Committee of Shenzhen[JSGG 20160608140847864]
WOS研究方向	Chemistry
WOS类目	Chemistry, Applied ; Chemistry, Organic
WOS记录号	WOS:000478036100006
出版者	WILEY-V C H VERLAG GMBH
来源库	Web of Science
引用统计	被引频次[WOS]：12
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/25673
专题	理学院_化学系深圳格拉布斯研究院
作者单位	1.Wuhan Univ, Coll Chem & Mol Sci, Engn Res Ctr Organosilicon Cpds & Mat, Key Lab Biomed Polymers,Minist Educ, Wuhan 430072, Hubei, Peoples R China 2.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Guangdong, Peoples R China 3.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Guangdong, Peoples R China
通讯作者单位	化学系; 深圳格拉布斯研究院
推荐引用方式 GB/T 7714	Liu, Gang,Li, Anqi,Qin, Xueyuan,et al. Efficient Access to Chiral beta-Borylated Carboxylic Esters via Rh-Catalyzed Hydrogenation[J]. ADVANCED SYNTHESIS & CATALYSIS,2019,361(12):2844-2848.
APA	Liu, Gang,Li, Anqi,Qin, Xueyuan,Han, Zhengyu,Dong, Xiu-Qin,&Zhang, Xumu.(2019).Efficient Access to Chiral beta-Borylated Carboxylic Esters via Rh-Catalyzed Hydrogenation.ADVANCED SYNTHESIS & CATALYSIS,361(12),2844-2848.
MLA	Liu, Gang,et al."Efficient Access to Chiral beta-Borylated Carboxylic Esters via Rh-Catalyzed Hydrogenation".ADVANCED SYNTHESIS & CATALYSIS 361.12(2019):2844-2848.