The significance of dual-mode elastography in the diagnosis of breast lesions by physicians with different levels of experience

Huang, Sijing; Ye, Xiuqin; Yang, Keen; Tian, Hongtian; Ding, Zhimin; Chen, Jing; Xu, Jinfeng1,2; Dong, Fajin1,2

2021-10-01

10.21037/qims-21-636

Quantitative Imaging in Medicine and Surgery   影响因子和分区

2223-4292

2223-4306

["Background: This study aimed to assess the diagnostic value of dual-mode elastography for benign and malignant breast lesions and determine whether this technique can improve the diagnostic ability of physicians with different levels of experience.","Methods: One hundred and eighty-three breast lesions were analyzed retrospectively, and the following values were calculated for the lesions with various shells: shear modulus (G), Young's modulus (E), shear wave velocity (Cs), and strain ratio (SR). A random forest algorithm was used to select the optimal modes for elastography. A receiver operating characteristic curve was used to assess the diagnostic efficacy for benign and malignant breast lesions. Sensitivity and specificity values were calculated to evaluate any improvements in the diagnostic efficacy of physicians with different levels of experience (junior, intermediate-level, and senior) in the evaluation of malignant breast lesions using dual-mode elastography.","Results: The best-performing mode of shear wave elastography (SWE) in the diagnosis of breast lesions was the A'min 1.0 (Cs) mode (minimum shear wave velocity of the area of interest and 1.0 mm around the area of interest), and the best-performing mode of strain elastography (SE) was the B/A' 0.5 (ratio of fat to the elasticity of the area of interest and 0.5 mm around the area of interest). When the two methods were used in series, results showed high specificity (98%), positive likelihood ratio (PLR) (21.2), and positive predictive value (PPV) (95%). Series means that if SE and SWE were malignant, the result in series was malignant, and that if either SE or SWE was benign, the result in series was benign. When the methods were used in parallel, the results showed high sensitivity (91%), negative likelihood ratio (NLR) (0.15), and negative predictive value (NPV) (89%). Parallel means that if SE and SWE were benign, the result in parallel was benign, and that if either SE or SWE was malignant, the result in parallel was malignant. When conventional ultrasound was combined with dual-mode elastography, the intermediate-level and junior physicians' diagnoses of breast lesions showed a higher sensitivity, specificity, and area under the curve than conventional ultrasound diagnosis alone.","Conclusions: Dual-mode elastography is effective in the diagnosis of breast lesions. The sensitivity and specificity values in this study show that diagnoses made by junior and intermediate-level physicians improve when dual-mode elastography is used, although diagnoses made by senior physicians do not improve significantly."]

Breast cancer ultrasound elastography diagnosis

SCI

英语

通讯

Commission of Science and Technology of Shenzhen[GJHZ20200731095401004]

Radiology, Nuclear Medicine & Medical Imaging

Radiology, Nuclear Medicine & Medical Imaging

WOS:000720571600001

AME PUBL CO

2-s2.0-85121121901

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Ultrasound, Shenzhen 518172, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518172, Guangdong, Peoples R China

Huang, Sijing,Ye, Xiuqin,Yang, Keen,et al. The significance of dual-mode elastography in the diagnosis of breast lesions by physicians with different levels of experience[J]. Quantitative Imaging in Medicine and Surgery,2021,12(2):1438-1449.

Huang, Sijing.,Ye, Xiuqin.,Yang, Keen.,Tian, Hongtian.,Ding, Zhimin.,...&Dong, Fajin.(2021).The significance of dual-mode elastography in the diagnosis of breast lesions by physicians with different levels of experience.Quantitative Imaging in Medicine and Surgery,12(2),1438-1449.

Huang, Sijing,et al."The significance of dual-mode elastography in the diagnosis of breast lesions by physicians with different levels of experience".Quantitative Imaging in Medicine and Surgery 12.2(2021):1438-1449.