南方科技大学知识苑(SUSTech KC): Different Effects of Hematoma Expansion on Short-Term Functional Outcome in Basal Ganglia and Thalamic Hemorrhages

题名	Different Effects of Hematoma Expansion on Short-Term Functional Outcome in Basal Ganglia and Thalamic Hemorrhages
作者	Deng, Lijing 1; Chen, Kai 2; Yang, Liu 3; Deng, Zhaoxu 4; Zheng, Haijun 5
通讯作者	Chen, Kai
发表日期	2021-10-25
DOI	10.1155/2021/9233559
发表期刊	Biomed Research International 影响因子和分区
ISSN	2314-6133
EISSN	2314-6141
卷号	2021
摘要	Purpose. To investigate the impact of hematoma expansion (HE) on short-term functional outcome of patients with thalamic and basal ganglia intracerebral hemorrhage. Methods. Data of 420 patients with deep intracerebral hemorrhage (ICH) that received a baseline CT scan within 6 hours from symptom onset and a follow-up CT scan within 72 hours were retrospectively analyzed. The poor functional outcome was defined as modified Rankin score mRS>3 at 30 days. Receiver operating characteristic (ROC) curves for relative and absolute growth of HE were generated and compared. Multivariable logistic regression models were used to analyze the impact of HE on the functional outcome in basal ganglia and thalamic hemorrhages. The predictive values for different thresholds of HE were calculated, and correlation coefficient matrices were used to explore the correlation between the covariables. Results. Basal ganglia ICH showed a higher possibility of absolute hematoma growth than thalamic ICH. The area under the curve (AUC) for absolute and relative growth of thalamic hemorrhage was lower than that of basal ganglia hemorrhage (AUC 0.71 and 0.67, respectively) in discriminating short-term poor outcome with an AUC of 0.59 and 0.60, respectively. Each threshold of HE independently predicted poor outcome in basal ganglia ICH (P<0.001), with HE>3 ml and > 6 ml showing higher positive predictive values and accuracy compared to HE>33%. In contrast, thalamic ICH had a smaller baseline volume (BV, 9.55 +/- 6.85 ml) and was more likely to initially involve the posterior limb of internal capsule (PLIC) (85/153, 57.82%), and the risk of HE was lower without PLIC involvement (4.76%, P=0.009). Therefore, in multivariate analysis, the effect of thalamic HE on poor prognosis was largely replaced by BV and the involvement of PLIC, and the adjusted odds ratios (ORs) of HE was not significant (P>0.05). Conclusion. Though HE is a high-risk factor for short-term poor functional outcome, it is not an independent risk factor in thalamic ICH, and absolute growth is more predictive of poor outcome than relative growth for basal ganglia ICH.
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一
资助项目	Health Commission of Hunan Province[20200068]
WOS研究方向	Biotechnology & Applied Microbiology ; Research & Experimental Medicine
WOS类目	Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
WOS记录号	WOS:000717685800001
出版者	HINDAWI LTD
来源库	Web of Science
引用统计	被引频次[WOS]：4
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/256844
专题	南方科技大学第二附属医院南方科技大学第一附属医院
作者单位	1.Southern Univ Sci & Technol, Hosp 2, Shenzhen Peoples Hosp 3, Dept Neonatol, Shenzhen, Guangdong, Peoples R China 2.Shenzhen Samii Med Ctr, Dept Med Imaging, Shenzhen, Guangdong, Peoples R China 3.Jinan Univ, Affiliated Hosp 1, Dept Neurol, Guangzhou, Guangdong, Peoples R China 4.Xiangnan Univ, Affiliated Hosp 2, Dept Radiol, Chenzhou, Hunan, Peoples R China 5.Xiangnan Univ, Suxian Hosp, Dept Radiol, Chenzhou, Hunan, Peoples R China
第一作者单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Deng, Lijing,Chen, Kai,Yang, Liu,et al. Different Effects of Hematoma Expansion on Short-Term Functional Outcome in Basal Ganglia and Thalamic Hemorrhages[J]. Biomed Research International,2021,2021.
APA	Deng, Lijing,Chen, Kai,Yang, Liu,Deng, Zhaoxu,&Zheng, Haijun.(2021).Different Effects of Hematoma Expansion on Short-Term Functional Outcome in Basal Ganglia and Thalamic Hemorrhages.Biomed Research International,2021.
MLA	Deng, Lijing,et al."Different Effects of Hematoma Expansion on Short-Term Functional Outcome in Basal Ganglia and Thalamic Hemorrhages".Biomed Research International 2021(2021).