Role of long intergenic non-protein coding RNA 01857 in hepatocellular carcinoma malignancy via the regulation of the microRNA-197-3p/anterior GRadient 2 axis

Bi，Jiangang1; Guo，Yusheng1; Li，Qi1; Liu，Liping1; Bao，Shiyun1; Xu，Ping2

2021-11-01

10.1371/journal.pone.0258312

PLoS One   影响因子和分区

1932-6203

1932-6203

This study investigates the differential expression and the mechanism of long intergenic non-protein coding RNA (LINC) 01857 in hepatocellular carcinoma (HCC) proliferation and apoptosis. Methods LINC01857 expression in HCC tissues and cells was evaluated. In addition, gain-of and loss-of functions were carried out to assess HCC cell proliferation and apoptosis. After that, LINC01857 subcellular localization was predicted and verified. Additionally, the binding relations between LINC01857 and microRNA (miRNA)-197-3p and between miR-197-3p and anterior GRadient 2 (AGR2) were detected and confirmed. Besides, HCC cell proliferation and apoptosis were assessed after silencing LINC01857 or overexpressing AGR2. Next, levels of key factors in the AKT and ERK pathways were measured. Additionally, xenograft transplantation was also conducted to confirm the effect of LINC01857 in HCC.

SCI

英语

第一 ; 通讯

Medical Science and Technology Research Foundation of Guangdong Province[A2020559]

Science & Technology - Other Topics

Multidisciplinary Sciences

WOS:000755319200020

PUBLIC LIBRARY SCIENCE

2-s2.0-85119622026

Scopus

1.Department of Hepatopancreatobiliary Surgery,Shenzhen People’s Hospital,Second Clinical Medical College of Jinan University,Southern University of Science and Technology,Shenzhen,China
2.Department of Endocrinology,Shenzhen People’s Hospital,Second Clinical Medical College of Jinan University,Southern University of Science and Technology,Shenzhen,China

Bi，Jiangang,Guo，Yusheng,Li，Qi,et al. Role of long intergenic non-protein coding RNA 01857 in hepatocellular carcinoma malignancy via the regulation of the microRNA-197-3p/anterior GRadient 2 axis[J]. PLoS One,2021,16(11 November).

Bi，Jiangang,Guo，Yusheng,Li，Qi,Liu，Liping,Bao，Shiyun,&Xu，Ping.(2021).Role of long intergenic non-protein coding RNA 01857 in hepatocellular carcinoma malignancy via the regulation of the microRNA-197-3p/anterior GRadient 2 axis.PLoS One,16(11 November).

Bi，Jiangang,et al."Role of long intergenic non-protein coding RNA 01857 in hepatocellular carcinoma malignancy via the regulation of the microRNA-197-3p/anterior GRadient 2 axis".PLoS One 16.11 November(2021).