Atomic layer deposition of zinc oxide onto 3D porous iron scaffolds for bone repair: in vitro degradation, antibacterial activity and cytocompatibility evaluation

Li，Yu Lei1; He，Jin1; Ye，Hai Xia1; Zhao，Can Can1; Zhu，Wei Wei1,2; Lu，Xiong3; Ren，Fu Zeng1

2022-02-01

10.1007/s12598-021-01852-8

RARE METALS   影响因子和分区

1001-0521

1867-7185

3D porous iron (Fe) scaffolds with interconnected open pores are promising candidates for bone repair. However, the bare 3D porous Fe scaffolds lack of antibacterial activity and the ability for cell adhesion. Herein, atomic layer deposition technique was used to deposit nanometer-thick zinc oxide (ZnO) layer onto the skeleton of 3D porous Fe scaffolds with interconnected open pores. The effect of ZnO thin film on the in vitro degradation behavior, antibacterial activity and cytocompatibility of 3D porous Fe scaffolds was systematically evaluated. The results showed that a dense ZnO thin film with a thickness of 76 nm was uniformly deposited on the skeleton of the porous Fe scaffolds. The thickness of ZnO thin film could be easily controlled by the deposition cycles. The deposited ZnO thin film significantly reduced the degradation rate of porous Fe scaffolds and the fabricated ZnO coated porous Fe scaffolds demonstrated strong antibacterial ability against both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus, while did not significantly affect cytocompatibility and could also promote cell adhesion. Graphical abstract: [Figure not available: see fulltext.].

Antibacterial activity Atomic layer deposition Porous iron scaffolds ZnO

SCI ; EI

英语

第一

20214811227746

Atomic layer deposition ; Atoms ; Biodegradation ; Bone ; Cell adhesion ; Degradation ; Escherichia coli ; Film thickness ; II-VI semiconductors ; Iron ; Metallic films ; Optical films ; Scaffolds (biology) ; Surface roughness ; Thin films

Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Biotechnology:461.8 ; Biology:461.9 ; Iron:545.1 ; Semiconducting Materials:712.1 ; Optical Devices and Systems:741.3 ; Biochemistry:801.2 ; Chemical Reactions:802.2 ; Inorganic Compounds:804.2 ; Coating Techniques:813.1 ; Physical Properties of Gases, Liquids and Solids:931.2 ; Atomic and Molecular Physics:931.3 ; Crystal Growth:933.1.2

MATERIALS SCIENCE

2-s2.0-85119688540

Scopus

1.Department of Materials Science and Engineering,Southern University of Science and Technology,Shenzhen,518055,China
2.Institute of Applied Physics and Materials Engineering,Faculty of Science and Technology,University of Macau,999078,Macao
3.Key Lab of Advanced Technologies of Materials,Ministry of Education,School of Materials Science and Engineering,Southwest Jiaotong University,Chengdu,610031,China

Li，Yu Lei,He，Jin,Ye，Hai Xia,et al. Atomic layer deposition of zinc oxide onto 3D porous iron scaffolds for bone repair: in vitro degradation, antibacterial activity and cytocompatibility evaluation[J]. RARE METALS,2022,41(2):546-558.

Li，Yu Lei.,He，Jin.,Ye，Hai Xia.,Zhao，Can Can.,Zhu，Wei Wei.,...&Ren，Fu Zeng.(2022).Atomic layer deposition of zinc oxide onto 3D porous iron scaffolds for bone repair: in vitro degradation, antibacterial activity and cytocompatibility evaluation.RARE METALS,41(2),546-558.

Li，Yu Lei,et al."Atomic layer deposition of zinc oxide onto 3D porous iron scaffolds for bone repair: in vitro degradation, antibacterial activity and cytocompatibility evaluation".RARE METALS 41.2(2022):546-558.