| 题名 | Time‐Dependent Photodynamic Therapy for Multiple Targets: A Highly Efficient AIE‐Active Photosensitizer for Selective Bacterial Elimination and Cancer Cell Ablation |
| 作者 | |
| 通讯作者 | Jianguo,Wang; Ben Zhong,Tang |
| 共同第一作者 | Ying,Li; Tianliang,Min; Junyi,Gong |
| 发表日期 | 2019-10-21
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| DOI | |
| 发表期刊 | |
| ISSN | 0044-8249
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| 卷号 | 132期号:24页码:9557-9564 |
| 摘要 | Pathogen infections and cancer are two major human health problems. Herein, we report the synthesis of an organic salt photosensitizer (PS), called 4TPA-BQ, by a one step reaction. 4TPA-BQ presents aggregation-induced emission features. Owing to the aggregation-induced reactive
oxygen species generated and a sufficiently small DEST, 4TPA-BQ shows a satisfactorily high 1O2 generation efficiency of 97.8%. In vitro and in vivo experiments confirmed that 4TPA-BQ exhibited potent photodynamic antibacterial performance against ampicillin-resistant Escherichia coli with
good biocompatibility in a short time (15 minutes). When the incubation duration persisted long enough (12 hours), cancer cells were ablated efficiently, leaving normal cells essentially unaffected. This is the first reported time-dependent fluorescence-guided photodynamic therapy in one individual PS, which achieves ordered and multiple targeting simply by varying the external conditions. 4TPA-BQ reveals new design
principles for the implementation of efficient PSs in clinical applications. |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 共同第一
; 其他
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| 出版者 | |
| 来源库 | 人工提交
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| 引用统计 |
被引频次[WOS]：0
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/257160 |
| 专题 | 工学院_生物医学工程系 |
| 作者单位 | 1.Department of Chemistry, Hong Kong Branch of Chinese National Engineering 2.Research Center for Tissue Restoration and Reconstruction, Institute of Molecular Functional Materials, State Key Laboratory of Molecular Nanoscience, Division of Life Science and Department of Chemical and Biomedical Engineering, The Hong Kong University of Science and Technology, Clear Water Bay Kowloon, Hong Kong (China) 3.College of Materials Science and Engineering, Shenzhen University Shenzhen 518060 (China) 4.Department of Biomedical Engineering Southern University of Science and Technology Shenzhen, Guangdong 518055 (China) 5.Department of Chemistry, The University of Hong Kong Pokfulam Road, Hong Kong (China) 6.College of Chemistry and Chemical Engineering Inner Mongolia University Hohhot 010021 (China) |
| 推荐引用方式 GB/T 7714 |
Qiyao,Li,Ying,Li,Tianliang,Min,等. Time‐Dependent Photodynamic Therapy for Multiple Targets: A Highly Efficient AIE‐Active Photosensitizer for Selective Bacterial Elimination and Cancer Cell Ablation[J]. Angewandte Chemie,2019,132(24):9557-9564.
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| APA |
Qiyao,Li.,Ying,Li.,Tianliang,Min.,Junyi,Gong.,Lili,Du.,...&Ben Zhong,Tang.(2019).Time‐Dependent Photodynamic Therapy for Multiple Targets: A Highly Efficient AIE‐Active Photosensitizer for Selective Bacterial Elimination and Cancer Cell Ablation.Angewandte Chemie,132(24),9557-9564.
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| MLA |
Qiyao,Li,et al."Time‐Dependent Photodynamic Therapy for Multiple Targets: A Highly Efficient AIE‐Active Photosensitizer for Selective Bacterial Elimination and Cancer Cell Ablation".Angewandte Chemie 132.24(2019):9557-9564.
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| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | 操作 | |
| anie.201909706.pdf（2854KB） | -- | -- | 限制开放 | -- | ||
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