Strontium chondroitin sulfate/silk fibroin blend membrane containing microporous structure modulates macrophage responses for guided bone regeneration

Ma Fenbo1; Xia Xingyu2; Tang Bin1,3,4

2019-06

10.1016/j.carbpol.2019.02.068

CARBOHYDRATE POLYMERS   影响因子和分区

0144-8617

1879-1344

A membrane used for guided bone regeneration (GBR) serves as a bioactive compartment rather than a physical barrier. However, the pure membrane may not provide an optimal microenvironment for bone formation and remodeling. Here, a novel strontium chondroitin sulfate/silk fibroin (SrCS/SF) blend membrane containing microporous structure was fabricated. By increasing incorporation content of SrCS, SrCS/SF membranes exhibit better mechanical properties and higher water retention capacity. In vitro results reveal that higher content of SrCS membranes facilitate osteoblasts proliferation. The evaluation of the osteoimmunomodulatory effects of the membranes reveals that SrCS/SF membranes should have positive effects on modulating the osteoimmune response of macrophages, by downregulating the expression of pro-inflammatory cytokines and the expression of degradation related catabolic genes and upregulating osteogenic factors. It is therefore believed that the developed SrCS/SF membranes should be potentially used as multifunctional bioactive GBR membranes.

Silk fibroin Anti-inflammatory Strontium Chondroitin sulfate

SCI ; EI

英语

第一 ; 通讯

Shenzhen Science and Technology Innovation Committee[JCYJ20160517160827379] ; Shenzhen Science and Technology Innovation Committee[JCYJ20170817111312887] ; Shenzhen Science and Technology Innovation Committee[GRCK20160829195523424] ; Shenzhen Science and Technology Innovation Committee[ZDSYS20 140509142721429]

Chemistry ; Polymer Science

Chemistry, Applied ; Chemistry, Organic ; Polymer Science

WOS:000461316200029

ELSEVIER SCI LTD

20191006600964

Bone ; Gene expression ; Macrophages ; Membranes ; Microporosity ; Strontium ; Sulfur compounds

Bioengineering and Biology:461 ; Alkaline Earth Metals:549.2 ; Physical Properties of Gases, Liquids and Solids:931.2 ; Materials Science:951

CHEMISTRY

Web of Science

1.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen, Guangdong, Peoples R China
2.Univ Hong Kong, Dept Mech Engn, Hong Kong, Peoples R China
3.Guangdong Prov Key Lab Cell Microenvironm & Dis R, Shenzhen, Guangdong, Peoples R China
4.Shenzhen Key Lab Cell Microenvironm, Shenzhen, Peoples R China

Ma Fenbo,Xia Xingyu,Tang Bin. Strontium chondroitin sulfate/silk fibroin blend membrane containing microporous structure modulates macrophage responses for guided bone regeneration[J]. CARBOHYDRATE POLYMERS,2019,213:266-275.

Ma Fenbo,Xia Xingyu,&Tang Bin.(2019).Strontium chondroitin sulfate/silk fibroin blend membrane containing microporous structure modulates macrophage responses for guided bone regeneration.CARBOHYDRATE POLYMERS,213,266-275.

Ma Fenbo,et al."Strontium chondroitin sulfate/silk fibroin blend membrane containing microporous structure modulates macrophage responses for guided bone regeneration".CARBOHYDRATE POLYMERS 213(2019):266-275.