Hippocampus-Prefrontal Coupling Regulates Recognition Memory for Novelty Discrimination

Wang, Cong1,2; Furlong, Teri M.2,3,4; Stratton, Peter G.1; Lee, Conrad C. Y.1,2,5; Xu, Li1; Merlin, Sam2,6; Nolan, Chris1,2; Arabzadeh, Ehsan2,5; Marek, Roger1,2; Sah, Pankaj1,2,7,8

2021-11-17

10.1523/JNEUROSCI.1202-21.2021

JOURNAL OF NEUROSCIENCE   影响因子和分区

0270-6474

1529-2401

Recognition memory provides the ability to distinguish familiar from novel objects and places, and is important for recording and updating events to guide appropriate behavior. The hippocampus (HPC) and medial prefrontal cortex (mPFC) have both been implicated in recognition memory, but the nature of HPC-mPFC interactions, and its impact on local circuits in mediating this process is not known. Here we show that novelty discrimination is accompanied with higher theta activity (4-10 Hz) and increased c-Fos expression in both these regions. Moreover, theta oscillations were highly coupled between the HPC and mPFC during recognition memory retrieval for novelty discrimination, with the HPC leading the mPFC, but not during initial learning. Principal neurons and interneurons in the mPFC responded more strongly during recognition memory retrieval compared with learning. Optogenetic silencing of HPC input to the mPFC disrupted coupled theta activity between these two structures, as well as the animals' (male Sprague Dawley rats) ability to differentiate novel from familiar objects. These results reveal a key role of monosynaptic connections between the HPC and mPFC in novelty discrimination via theta coupling and identify neural populations that underlie this recognition memory-guided behavior.

context hippocampus memory novelty prefrontal cortex recognition

SCI

英语

通讯

Australian Research Council[CE140100007]

Neurosciences & Neurology

Neurosciences

WOS:000722583400001

SOC NEUROSCIENCE

NEUROSCIENCE & BEHAVIOR

Web of Science

1.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
2.Australian Res Council, Ctr Excellence Integrat Brain Funct, Clayton, Vic 3800, Australia
3.Neurosci Res Australia, Sydney, NSW 2031, Australia
4.Univ New South Wales, Sch Med Sci, Sydney, NSW 2052, Australia
5.Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia
6.Western Sydney Univ, Sch Sci, Campbelltown, NSW 2560, Australia
7.Southern Univ Sci & Technol, Joint Ctr Neurosci & Neural Engn, Shenzhen 518055, Guangdong, Peoples R China
8.Southern Univ Sci & Technol, Dept Biol, Shenzhen 518055, Guangdong, Peoples R China

Wang, Cong,Furlong, Teri M.,Stratton, Peter G.,et al. Hippocampus-Prefrontal Coupling Regulates Recognition Memory for Novelty Discrimination[J]. JOURNAL OF NEUROSCIENCE,2021,41(46).

Wang, Cong.,Furlong, Teri M..,Stratton, Peter G..,Lee, Conrad C. Y..,Xu, Li.,...&Sah, Pankaj.(2021).Hippocampus-Prefrontal Coupling Regulates Recognition Memory for Novelty Discrimination.JOURNAL OF NEUROSCIENCE,41(46).

Wang, Cong,et al."Hippocampus-Prefrontal Coupling Regulates Recognition Memory for Novelty Discrimination".JOURNAL OF NEUROSCIENCE 41.46(2021).