| 题名 | JQ1, a BET-bromodomain inhibitor, inhibits human cancer growth and suppresses PD-L1 expression |
| 作者 | |
| 通讯作者 | Guo, Jinan; Wan, Yong; Chen, Rui |
| 发表日期 | 2019-06
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| DOI | |
| 发表期刊 | |
| ISSN | 1065-6995
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| EISSN | 1095-8355
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| 卷号 | 43期号:6页码:642-650 |
| 摘要 | Most traditional cytotoxic chemotherapeutic agents have poor aqueous solubility and significant toxicity. Hence, there is a need to develop molecule-targeted drugs. Programmed death-ligand 1 (PD-L1) is associated with the prognosis of several cancer types, and blockade of PD-1/PD-L1 signaling increases the amplitude of anti-tumor immunity. In the present study, we investigated the effects of JQ1, a bromodomain and extraterminal-bromodomain inhibitor, on cell growth, and messenger RNA (mRNA) and protein levels of PD-L1 in renal cell carcinoma primary culture cells, and prostate, liver, and lung cancer cell lines. The results of the cell counting kit-8 assay suggested that JQ1 inhibits cell growth in a dose-dependent manner. The mRNA and protein levels of PD-L1 decreased in the primary culture of JQ1-treated renal carcinoma, prostate cancer, liver cancer, and lung cancer cell lines. In addition, the mRNA level of PD-L2 also decreased in the JQ1-treated cells. Overall, JQ1 might be a potential anti-tumor agent. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 第一
; 通讯
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| 资助项目 | National Natural Science Foundation of China[81802749]
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| WOS研究方向 | Cell Biology
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| WOS类目 | Cell Biology
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| WOS记录号 | WOS:000469397200007
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| 出版者 | |
| ESI学科分类 | MOLECULAR BIOLOGY & GENETICS
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| 来源库 | Web of Science
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| 引用统计 |
被引频次[WOS]：26
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/25755 |
| 专题 | 南方科技大学第一附属医院 |
| 作者单位 | 1.Jinan Univ, Southern Univ Sci & Technol, Clin Med Coll 2, Affiliated Hosp 1,Shenzhen Peoples Hosp, Guangzhou 518020, Guangdong, Peoples R China 2.Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Hong Kong 999077, Peoples R China |
| 第一作者单位 | 南方科技大学第一附属医院 |
| 通讯作者单位 | 南方科技大学第一附属医院 |
| 第一作者的第一单位 | 南方科技大学第一附属医院 |
| 推荐引用方式 GB/T 7714 |
Liu, Kaisheng,Zhou, Zhifan,Gao, Hengyuan,et al. JQ1, a BET-bromodomain inhibitor, inhibits human cancer growth and suppresses PD-L1 expression[J]. CELL BIOLOGY INTERNATIONAL,2019,43(6):642-650.
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| APA |
Liu, Kaisheng.,Zhou, Zhifan.,Gao, Hengyuan.,Yang, Fang.,Qian, Yajun.,...&Chen, Rui.(2019).JQ1, a BET-bromodomain inhibitor, inhibits human cancer growth and suppresses PD-L1 expression.CELL BIOLOGY INTERNATIONAL,43(6),642-650.
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| MLA |
Liu, Kaisheng,et al."JQ1, a BET-bromodomain inhibitor, inhibits human cancer growth and suppresses PD-L1 expression".CELL BIOLOGY INTERNATIONAL 43.6(2019):642-650.
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| 条目包含的文件 | 条目无相关文件。 | |||||
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