Bioinspired, injectable, tissue-adhesive and antibacterial hydrogel for multiple tissue regeneration by minimally invasive therapy

Zhou，Feifei1; Yang，Yuan1,4; Zhang，Wenjing3,5; Liu，Shuyu1; Shaikh，Atik Badshah4; Yang，Lei1; Lai，Yuxiao3; Ouyang，Hongwei2; Zhu，Weimin1

2022-03-01

10.1016/j.apmt.2021.101290

Applied Materials Today   影响因子和分区

2352-9407

Hemorrhage and wound infection after soft tissue trauma are the main factors causing casualties in surgical procedures and disasters. Currently available tissue adhesives for hemorrhage and wound infection treatment remain unsatisfactory due to the lack of ideal adhesive hydrogels that can integrate injectability, tunable mechanical strength, matching irregular defect and antibacterial property into one system. Here, inspired by the mussel adhesive protein and the natural extracellular matrix (ECM) composition, we engineered a gelatin-based adhesive hydrogel (Dopamine modified methacrylate gelatin, GMDA) with strong tissue adhesiveness and antibacterial property. This bioinspired injectable hydrogel demonstrated tunable mechanical properties and optimal elasticity due to the double-crosslinked network formed through the horseradish peroxidase (HRP) / hydrogen peroxide (HO) and ultraviolet (UV) light crosslinking. In addition, these adhesive hydrogels could withstand up to 250 mmHg blood pressure (significantly higher than normal blood pressure, systolic BP 60–160 mmHg) and showed superior hemostasis capability of uncontrolled bleeding in vivo. Most importantly, the hydrogel exhibited significant antibacterial property because of the released residual HO after hydrogel formation. Further in vivo studies demonstrated that the hydrogel loaded with epidermal growth factor (EGF) could promote efficient skin regeneration with the formation of skin appendages. These findings shed new light on developing a multifunctional bioinspired adhesive hydrogel that could serve as a promising biomaterial for hemostasis and wound infection treatment and other minimally invasive use of biomedical applications.

Antibacterial Bioinspired injectable hydrogel Gmda Hemostasis Wound healing

SCI ; EI

英语

其他

20214911283099

Adhesives ; Amines ; Biomechanics ; Blood ; Blood pressure ; Hydrogels ; Medical applications ; Mercury compounds ; Tissue

Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Biomechanics, Bionics and Biomimetics:461.3 ; Biology:461.9 ; Colloid Chemistry:801.3 ; Chemical Products Generally:804 ; Organic Compounds:804.1

2-s2.0-85120477866

Scopus

1.Shenzhen Second People's Hospital,The First Affiliated Hospital of Shenzhen University,Shenzhen,China
2.Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine,And Department of Orthopedic Surgery of the Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China
3.Centre for Translational Medicine Research & Development,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,China
4.Orthopaedic Medicine Department,Southern University of Science and Technology Hospital,Shenzhen,China
5.University of Chinese Academy of Sciences,Beijing,China

Zhou，Feifei,Yang，Yuan,Zhang，Wenjing,et al. Bioinspired, injectable, tissue-adhesive and antibacterial hydrogel for multiple tissue regeneration by minimally invasive therapy[J]. Applied Materials Today,2022,26.

Zhou，Feifei.,Yang，Yuan.,Zhang，Wenjing.,Liu，Shuyu.,Shaikh，Atik Badshah.,...&Zhu，Weimin.(2022).Bioinspired, injectable, tissue-adhesive and antibacterial hydrogel for multiple tissue regeneration by minimally invasive therapy.Applied Materials Today,26.

Zhou，Feifei,et al."Bioinspired, injectable, tissue-adhesive and antibacterial hydrogel for multiple tissue regeneration by minimally invasive therapy".Applied Materials Today 26(2022).