Evaluation of gas chromatography-atmospheric pressure chemical ionization tandem mass spectrometry as an alternative to gas chromatography tandem mass spectrometry for the determination of polychlorinated biphenyls and polybrominated diphenyl ethers

Fang, Jing1; Zhao, Hongzhi1; Zhang, Yanhao1; Wong, Minghung6,7; He, Yu1,2; Sun, Qianqian2; Xu, Shunqing3,4,5; Cai, Zongwei1

2019-06

10.1016/j.chemosphere.2019.03.011

CHEMOSPHERE   影响因子和分区

0045-6535

1879-1298

A method for the analysis of polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in serum was developed using gas chromatography coupled to tandem mass spectrometry with atmospheric pressure chemical ionization (GC-APCI-MS/MS). The ionization and fragmentation performance of APCI were evaluated and compared with those of electron ionization (EI). In contrast to extensive fragmentation caused by El with high energy, soft ionization achieved by APCI produced mass spectra dominated by molecular ions from the first stage of MS analysis. Better sensitivity and selectivity achieved by the GC-APCI-MS/MS method allowed to analyze serum samples with a low volume (100 mu L). The limits of detection (LODs) ranged from 0.067 to 14 pg/mL for the analysis in serum samples. The developed method was evaluated at three spiking levels (0.05, 0.5 and 5 ng/mL for PCBs), showing good recoveries and repeatability. The recoveries ranged from 74.0% to 130.5%, and the relative standard deviations (RSDs) were less than 20%, for all analytes. The determination of PCBs and PBDEs in the human serum samples by GC-APCI-MS/MS was compared with gas chromatography -tandem mass spectrometry with El (GC-EI-MS/MS). BDE-99 and BDE-100 were successfully quantified by GC-APCI-MS/MS, while these two PBDE congeners were not detected by GC-EI-MS/MS. The GC-APCI-MS/MS method had a clear advantage when analyzing compounds at low levels. (C) 2019 Elsevier Ltd. All rights reserved.

APCI PCBs PBDEs Human serum

SCI ; EI

英语

其他

National Natural Science Foundation of China[21437002]

Environmental Sciences & Ecology

Environmental Sciences

WOS:000467668500032

PERGAMON-ELSEVIER SCIENCE LTD

20191206663868

Atmospheric chemistry ; Atmospheric ionization ; Atmospheric pressure ; Body fluids ; Ethers ; Mass spectrometry ; Organic pollutants ; Polychlorinated biphenyls

Atmospheric Properties:443.1 ; Biological Materials and Tissue Engineering:461.2 ; Chemistry:801 ; Chemical Operations:802.3 ; Organic Compounds:804.1

ENVIRONMENT/ECOLOGY

Web of Science

1.Hong Kong Baptist Univ, Dept Chem, State Key Lab Environm & Biol Anal, Hong Kong, Peoples R China
2.Fuzhou Univ, Coll Chem, MOE Key Lab Analyt Sci Food Safety & Biol, Fuzhou 350116, Fujian, Peoples R China
3.Huazhong Univ Sci & Technol, Sch Publ Hlth, Minist Educ, Key Lab Environm & Hlth, Wuhan, Hubei, Peoples R China
4.Huazhong Univ Sci & Technol, Sch Publ Hlth, Minist Environm Protect, Wuhan, Hubei, Peoples R China
5.Huazhong Univ Sci & Technol, Sch Publ Hlth, State Key Lab Environm Hlth Incubat, Wuhan, Hubei, Peoples R China
6.Southern Univ Sci & Technol, Sch Environm Sci & Engn, Guangdong Prov Key Lab Soil & Groundwater Pollut, Shenzhen, Peoples R China
7.Educ Univ Hong Kong, CHEER, Hong Kong, Peoples R China

Fang, Jing,Zhao, Hongzhi,Zhang, Yanhao,et al. Evaluation of gas chromatography-atmospheric pressure chemical ionization tandem mass spectrometry as an alternative to gas chromatography tandem mass spectrometry for the determination of polychlorinated biphenyls and polybrominated diphenyl ethers[J]. CHEMOSPHERE,2019,225:288-294.

Fang, Jing.,Zhao, Hongzhi.,Zhang, Yanhao.,Wong, Minghung.,He, Yu.,...&Cai, Zongwei.(2019).Evaluation of gas chromatography-atmospheric pressure chemical ionization tandem mass spectrometry as an alternative to gas chromatography tandem mass spectrometry for the determination of polychlorinated biphenyls and polybrominated diphenyl ethers.CHEMOSPHERE,225,288-294.

Fang, Jing,et al."Evaluation of gas chromatography-atmospheric pressure chemical ionization tandem mass spectrometry as an alternative to gas chromatography tandem mass spectrometry for the determination of polychlorinated biphenyls and polybrominated diphenyl ethers".CHEMOSPHERE 225(2019):288-294.