南方科技大学知识苑(SUSTech KC): Transcription factor YY1 is essential for iNKT cell development

题名	Transcription factor YY1 is essential for iNKT cell development
作者	Ou, Xijun1,2 ; Huo, Jianxin 1; Huang, Yuhan 1; Li, Yan-Feng 1; Xu, Shengli 1,3; Lam, Kong-Peng 1,3,4,5,6
通讯作者	Ou, Xijun; Xu, Shengli; Lam, Kong-Peng
发表日期	2019-06
DOI	10.1038/s41423-018-0002-6
发表期刊	Cellular & Molecular Immunology 影响因子和分区
ISSN	1672-7681
EISSN	2042-0226
卷号	16 期号:6页码:547-556
摘要	Invariant natural killer T (iNKT) cells develop from CD4(+)CD8(+) double-positive (DP) thymocytes and express an invariant V(alpha)14-J(alpha)18 T-cell receptor (TCR) alpha-chain. Generation of these cells requires the prolonged survival of DP thymocytes to allow for V(alpha)14-J(alpha)18 gene rearrangements and strong TCR signaling to induce the expression of the iNKT lineage-specific transcription factor PLZF. Here, we report that the transcription factor Yin Yang 1 (YY1) is essential for iNKT cell formation. Thymocytes lacking YY1 displayed a block in iNKT cell development at the earliest progenitor stage. YY1-deficient thymocytes underwent normal V(alpha)14-J(alpha)18 gene rearrangements, but exhibited impaired cell survival. Deletion of the apoptotic protein BIM failed to rescue the defect in iNKT cell generation. Chromatin immunoprecipitation and deep-sequencing experiments demonstrated that YY1 directly binds and activates the promoter of the Plzf gene. Thus, YY1 plays essential roles in iNKT cell development by coordinately regulating cell survival and PLZF expression.
关键词	NKT cell PLZF YY1 Zbtb16
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	通讯
WOS研究方向	Immunology
WOS类目	Immunology
WOS记录号	WOS:000468349100004
出版者	NATURE PUBLISHING GROUP
来源库	Web of Science
引用统计	被引频次[WOS]：13
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/25799
专题	生命科学学院_生物系
作者单位	1.Agcy Sci Technol & Res, Bioproc Technol Inst, Immunol Grp, Singapore 138668, Singapore 2.Southern Univ Sci & Technol, Dept Biol, Shenzhen 518055, Peoples R China 3.Natl Univ Singapore, Dept Physiol, Singapore 117599, Singapore 4.Natl Univ Singapore, Dept Microbiol & Immunol, Singapore 117599, Singapore 5.Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pediat, Singapore 117599, Singapore 6.Nanyang Technol Univ, Sch Biol Sci, Singapore, Singapore
第一作者单位	生物系
通讯作者单位	生物系
推荐引用方式 GB/T 7714	Ou, Xijun,Huo, Jianxin,Huang, Yuhan,et al. Transcription factor YY1 is essential for iNKT cell development[J]. Cellular & Molecular Immunology,2019,16(6):547-556.
APA	Ou, Xijun,Huo, Jianxin,Huang, Yuhan,Li, Yan-Feng,Xu, Shengli,&Lam, Kong-Peng.(2019).Transcription factor YY1 is essential for iNKT cell development.Cellular & Molecular Immunology,16(6),547-556.
MLA	Ou, Xijun,et al."Transcription factor YY1 is essential for iNKT cell development".Cellular & Molecular Immunology 16.6(2019):547-556.