Novel niobium and silver toughened hydroxyapatite nanocomposites with enhanced mechanical and biological properties for load-bearing bone implants

Wei, Pengbo1,2; Fang, Ju1; Fang, Liming3; Wang, Kefeng4; Lu, Xiong5; Ren, Fuzeng1

2019-06

10.1016/j.apmt.2019.04.009

Applied Materials Today   影响因子和分区

2352-9407

An ideal load-bearing implant material for hard tissue replacement requires a combination of excellent mechanical properties and biological functions. However, such combination can hardly be achieved by monolithic bioceramics or metals. To this end, by combining the individual characteristic advantages of hydroxyapatite (HA), niobium (Nb) and silver (Ag), we have developed novel Nb and Ag co-reinforced HA nanocomposites by high energy ball milling (HEBM) and spark plasma sintering (SPS). The fabricated HA-20Nb and HA-15Nb-5Ag (wt%) show nanocomposite microstructure with metallic reinforcements uniformly dispersed in the HA matrix. The formation of a nanothick Ca4Nb2O9 transition layer at the interfaces of HA/Nb enables high interface strength between the reinforcements and the HA matrix. Addition of Nb or Nb-Ag could significantly increase the compressive strength and fracture toughness of HA. In vitro and in vivo evaluations further show that addition of Nb could promote osteoblast proliferation, increase the osteogenic differentiation and enhance the osteointegration ability. Incorporation of Ag could remarkably increase the antibacterial activity both against Gram-positive organism Staphylococcus aureus and Gram-negative organism Escherichia coli. Thus, the developed new nanocomposites can bridge the gap between the mechanical and biofunctional requirements for load-bearing bone implants. (C) 2019 Elsevier Ltd. All rights reserved.

Hydroxyapatite Nanocomposite Interface Antibacterial Implants

SCI ; EI

英语

第一 ; 通讯

Fundamental Research Program of Shenzhen[JCYJ20170307110418960] ; Fundamental Research Program of Shenzhen[JCYJ20170412153039309]

Materials Science

Materials Science, Multidisciplinary

WOS:000471234900052

ELSEVIER SCIENCE BV

20192607122276

Ball milling ; Bearings (machine parts) ; Bioceramics ; Biological implants ; Biological materials ; Bone ; Calcium compounds ; Compressive strength ; Dental prostheses ; Escherichia coli ; Fracture toughness ; Hydroxyapatite ; Interfaces (materials) ; Mechanical properties ; Nanocomposites ; Niobium ; Niobium compounds ; Reinforcement ; Silver ; Spark plasma sintering

Biological Materials and Tissue Engineering:461.2 ; Dental Equipment and Supplies:462.3 ; Biomaterials (including synthetics):462.5 ; Metallurgy and Metallography:531 ; Precious Metals:547.1 ; Nonferrous Metals and Alloys excluding Alkali and Alkaline Earth Metals:549.3 ; Machine Components:601.2 ; Nanotechnology:761 ; Chemical Operations:802.3 ; Inorganic Compounds:804.2 ; Solid State Physics:933 ; Materials Science:951

Web of Science

1.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China
2.Hong Kong Univ Sci & Technol, Dept Mech & Aerosp Engn, Kowloon, Clear Water Bay, Hong Kong, Peoples R China
3.South China Univ Technol, Sch Mat Sci & Engn, Guangzhou 510641, Guangdong, Peoples R China
4.Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Sichuan, Peoples R China
5.SouthwestJiaotong Univ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat, Minist Educ, Chengdu 621000, Sichuan, Peoples R China

Wei, Pengbo,Fang, Ju,Fang, Liming,et al. Novel niobium and silver toughened hydroxyapatite nanocomposites with enhanced mechanical and biological properties for load-bearing bone implants[J]. Applied Materials Today,2019,15:531-542.

Wei, Pengbo,Fang, Ju,Fang, Liming,Wang, Kefeng,Lu, Xiong,&Ren, Fuzeng.(2019).Novel niobium and silver toughened hydroxyapatite nanocomposites with enhanced mechanical and biological properties for load-bearing bone implants.Applied Materials Today,15,531-542.

Wei, Pengbo,et al."Novel niobium and silver toughened hydroxyapatite nanocomposites with enhanced mechanical and biological properties for load-bearing bone implants".Applied Materials Today 15(2019):531-542.