A Mussel-Inspired Persistent ROS-Scavenging, Electroactive, and Osteoinductive Scaffold Based on Electrochemical-Driven In Situ Nanoassembly

Zhou, Ting1; Yan, Liwei1; Xie, Chaoming1; Li, Pengfei1; Jiang, Lili2; Fang, Ju3; Zhao, Cancan3; Ren, Fuzeng3; Wang, Kefeng4; Wang, Yingbo5; Zhang, Hongping6; Guo, Tailin1; Lu, Xiong1

2019-06

10.1002/smll.201805440

Small   影响因子和分区

1613-6810

1613-6829

Conductive polymers are promising for bone regeneration because they can regulate cell behavior through electrical stimulation; moreover, they are antioxidative agents that can be used to protect cells and tissues from damage originating from reactive oxygen species (ROS). However, conductive polymers lack affinity to cells and osteoinductivity, which limits their application in tissue engineering. Herein, an electroactive, cell affinitive, persistent ROS-scavenging, and osteoinductive porous Ti scaffold is prepared by the on-surface in situ assembly of a polypyrrole-polydopamine-hydroxyapatite (PPy-PDA-HA) film through a layer-by-layer pulse electrodeposition (LBL-PED) method. During LBL-PED, the PPy-PDA nanoparticles (NPs) and HA NPs are in situ synthesized and uniformly coated on a porous scaffold from inside to outside. PDA is entangled with and doped into PPy to enhance the ROS scavenging rate of the scaffold and realize repeatable, efficient ROS scavenging over a long period of time. HA and electrical stimulation synergistically promote osteogenic cell differentiation on PPy-PDA-HA films. Ultimately, the PPy-PDA-HA porous scaffold provides excellent bone regeneration through the synergistic effects of electroactivity, cell affinity, and antioxidative activity of the PPy-PDA NPs and the osteoinductivity of HA NPs. This study provides a new strategy for functionalizing porous scaffolds that show great promise as implants for tissue regeneration.

conductive polymers hydroxyapatite layer-by-layer electrochemical deposition mussel-inspired ROS-scavenging

SCI ; EI

英语

其他

Fundamental Research Funds for the Central Universities[2682018QY02] ; Fundamental Research Funds for the Central Universities[2682018ZT30] ; Fundamental Research Funds for the Central Universities[2682019JQ03]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000474266900012

WILEY-V C H VERLAG GMBH

20192206978154

Bone ; Cell engineering ; Electrochemical deposition ; Hydroxyapatite ; Molluscs ; Polymeric implants ; Polymers ; Polypyrroles ; Reduction ; Synthesis (chemical) ; Tissue ; Tissue regeneration

Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Marine Science and Oceanography:471 ; Chemical Reactions:802.2 ; Inorganic Compounds:804.2 ; Polymeric Materials:815.1 ; Organic Polymers:815.1.1

Web of Science

1.Southwest Jiaotong Univ, Sch Mat Sci & Engn, Minist Educ, Key Lab Adv Technol Mat, Chengdu 610031, Sichuan, Peoples R China
2.Xihua Univ, Key Lab Fluid & Power Machinery, Ctr Adv Mat & Energy, Minist Educ,Sch Mat Sci & Engn, Chengdu 610039, Sichuan, Peoples R China
3.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China
4.Sichuan Univ, Natl Engn Res Ctr Biomat, Genome Res Ctr Biomat, Chengdu 610064, Sichuan, Peoples R China
5.Xinjiang Normal Univ, Coll Chem Engn, 102 Xinyi Rd, Urumqi 830054, Xinjiang, Peoples R China
6.Southwest Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Engn Res Ctr Biomass Mat, Mianyang 621010, Sichuan, Peoples R China

Zhou, Ting,Yan, Liwei,Xie, Chaoming,et al. A Mussel-Inspired Persistent ROS-Scavenging, Electroactive, and Osteoinductive Scaffold Based on Electrochemical-Driven In Situ Nanoassembly[J]. Small,2019,15(25).

Zhou, Ting.,Yan, Liwei.,Xie, Chaoming.,Li, Pengfei.,Jiang, Lili.,...&Lu, Xiong.(2019).A Mussel-Inspired Persistent ROS-Scavenging, Electroactive, and Osteoinductive Scaffold Based on Electrochemical-Driven In Situ Nanoassembly.Small,15(25).

Zhou, Ting,et al."A Mussel-Inspired Persistent ROS-Scavenging, Electroactive, and Osteoinductive Scaffold Based on Electrochemical-Driven In Situ Nanoassembly".Small 15.25(2019).