Precisely Controlled Delivery of Abaloparatide through Injectable Hydrogel to Promote Bone Regeneration

Ning, Ziyu1; Tan, Baoyu1,2,3; Chen, Bo1,4; Lau, Dzi Shing Aaron1; Wong, Tak Man5; Sun, Tianhao1; Peng, Songlin2,3; Li, Zhaoyang6; Lu, William Weijia1,7

2019-06

10.1002/mabi.201900020

MACROMOLECULAR BIOSCIENCE   影响因子和分区

1616-5187

1616-5195

Side-effects from allograft, limited bone stock, and site morbidity from autograft are the major challenges to traditional bone defect treatments. With the advance of tissue engineering, hydrogel injection therapy is introduced as an alternative treatment. Therapeutic drugs and growth factors can be carried by hydrogels and delivered to patients. Abaloparatide, as an analog of human recombinant parathyroid hormone protein (PTHrp) and an alternative to teriparatide, has been considered as a drug for treating postmenopausal osteoporosis since 2017. Since only limited cases of receiving abaloparatide with polymeric scaffolds have been reported, the effects of abaloparatide on pre-osteoblast MC3T3-E1 are investigated in this study. It is found that in vitro abaloparatide treatment can promote pre-osteoblast MC3T3-E1 cells' viability, differentiation, and mineralization significantly. For the drug delivery system, 3D porous structure of the methacrylated gelatin (GelMA) hydrogel is found effective for prolonging the release of abaloparatide (more than 10 days). Therefore, injectable photo-crosslinked GelMA hydrogel is used in this study to prolong the release of abaloparatide and to promote healing of defected bones in rats. Overall, data collected in this study show no contradiction and imply that Abaloparatide-loaded GelMA hydrogel is effective in stimulating bone regeneration.

abaloparatide bone regeneration hydrogel methacrylated gelatin parathyroid hormone

SCI ; EI

英语

其他

Hong Kong General Research Fund[17206916]

Biochemistry & Molecular Biology ; Materials Science ; Polymer Science

Biochemistry & Molecular Biology ; Materials Science, Biomaterials ; Polymer Science

WOS:000471782900004

WILEY-V C H VERLAG GMBH

20192006921107

Bone ; Defects ; Diseases ; Drug interactions ; Hydrogels ; Recombinant proteins ; Scaffolds (biology) ; Targeted drug delivery

BIOLOGY & BIOCHEMISTRY

Web of Science

1.Univ Hong Kong, Li Ka Shing Fac Med, Dept Orthopaed & Traumatol, Hong Kong, Peoples R China
2.Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp,Coll Med 2,Dept Spine Surg, Shenzhen 518000, Peoples R China
3.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Inst Orthopaed Res,Coll Med 2,Affiliated Hosp 1, Shenzhen 518000, Peoples R China
4.Shanghai Jiao Tong Univ, Shanghai Key Lab Bone & Joint Dis, Shanghai Inst Traumatol & Orthopaed, Shanghai Ruijin Hosp,Sch Med, Shanghai 200000, Peoples R China
5.Univ Hong Kong, Dept Orthopaed & Traumatol, Queen Mary Hosp, Pokfulam, Hong Kong, Peoples R China
6.Tianjin Univ, Sch Mat Sci & Engn, Tianjin 300000, Peoples R China
7.Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen 518000, Peoples R China

Ning, Ziyu,Tan, Baoyu,Chen, Bo,et al. Precisely Controlled Delivery of Abaloparatide through Injectable Hydrogel to Promote Bone Regeneration[J]. MACROMOLECULAR BIOSCIENCE,2019,19(6).

Ning, Ziyu.,Tan, Baoyu.,Chen, Bo.,Lau, Dzi Shing Aaron.,Wong, Tak Man.,...&Lu, William Weijia.(2019).Precisely Controlled Delivery of Abaloparatide through Injectable Hydrogel to Promote Bone Regeneration.MACROMOLECULAR BIOSCIENCE,19(6).

Ning, Ziyu,et al."Precisely Controlled Delivery of Abaloparatide through Injectable Hydrogel to Promote Bone Regeneration".MACROMOLECULAR BIOSCIENCE 19.6(2019).