Functional groups influence and mechanism research of UiO-66-type metal-organic frameworks for ketoprofen delivery

Li, Zhen1,2,3; Zhao, Songjian4; Wang, Huizhen1; Peng, Ying1; Tan, Zhijie2,3; Tang, Bin1,5,6

2019-06

10.1016/j.colsurfb.2019.02.027

COLLOIDS AND SURFACES B-BIOINTERFACES   影响因子和分区

0927-7765

1873-4367

UiO-66 metal-organic framework (MOF) was introduced as ketoprofen delivery system for treating osteoarthritis (OA), and two different kinds of -NH2 and -NO2 functional groups were grafted into the UiO-66 framework to investigate the effect of functional groups on the drug loading level and release rate. Structural characterization of the samples showed that grafting functional groups had no significant effect on the morphological characteristic and crystal structure of UiO-66. All synthesized MOFs carriers had excellent BET, chemical and thermal stability, though the introduction of -NH2 and -NO2 functional groups were detrimental for these characteristics. Ketoprofen was successfully loaded on the MOFs carriers, and the results of high performance liquid chromatography (HPLC) indicated UiO-66-NH2 had the highest loading amount (38%). The ketoprofen release experiment manifested that UiO-66-NH2 exhibited lowest release rate and partial release of ketoprofen (about 65%) even after 72 h due to the high hydrogen bonds capacity and alkaline characteristic of -NH2. Furthermore, chondrocyte cytotoxicity experiment manifested that the synthesized MOFs carriers were rather bio-safe, which ensured them to be used as the drug delivery vehicles.

Metal-organic framework Ketoprofen Grafted Drug delivery

SCI ; EI

英语

第一 ; 通讯

Shenzhen Science and Technology Innovation Committee[JCYJ20160517160827379] ; Shenzhen Science and Technology Innovation Committee[JCYJ20170817111312887] ; Shenzhen Science and Technology Innovation Committee[GRCK20160829195523424] ; Shenzhen Science and Technology Innovation Committee[ZDSYS20140509142721429]

Biophysics ; Chemistry ; Materials Science

Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials

WOS:000471084400001

ELSEVIER SCIENCE BV

20190906559923

Alkalinity ; Chemical stability ; Crystal structure ; Crystalline materials ; Drug delivery ; Grafting (chemical) ; High performance liquid chromatography ; Hydrogen bonds ; Nitrogen oxides ; Organic polymers ; Organometallics ; Targeted drug delivery

Chemistry:801 ; Chemical Reactions:802.2 ; Organic Compounds:804.1 ; Inorganic Compounds:804.2 ; Organic Polymers:815.1.1 ; Crystalline Solids:933.1 ; Crystal Lattice:933.1.1

BIOLOGY & BIOCHEMISTRY

Web of Science

1.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China
2.Wuhan Univ, Sch Phys & Technol, Minist Educ, Dept Phys, Wuhan 430072, Hubei, Peoples R China
3.Wuhan Univ, Sch Phys & Technol, Minist Educ, Key Lab Artificial Micro & Nanostruct, Wuhan 430072, Hubei, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Environm Sci & Engn, 800 Dong Chuan Rd, Shanghai 200240, Peoples R China
5.Guangdong Prov Key Lab Cell Microenvironm & Dis R, Shenzhen, Guangdong, Peoples R China
6.Shenzhen Key Lab Cell Microenvironm, Shenzhen 518055, Peoples R China

Li, Zhen,Zhao, Songjian,Wang, Huizhen,et al. Functional groups influence and mechanism research of UiO-66-type metal-organic frameworks for ketoprofen delivery[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2019,178:1-7.

Li, Zhen,Zhao, Songjian,Wang, Huizhen,Peng, Ying,Tan, Zhijie,&Tang, Bin.(2019).Functional groups influence and mechanism research of UiO-66-type metal-organic frameworks for ketoprofen delivery.COLLOIDS AND SURFACES B-BIOINTERFACES,178,1-7.

Li, Zhen,et al."Functional groups influence and mechanism research of UiO-66-type metal-organic frameworks for ketoprofen delivery".COLLOIDS AND SURFACES B-BIOINTERFACES 178(2019):1-7.