Facile synthesis of near-infrared bodipy by donor engineering forin vivotumor targeted dual-modal imaging

An，Feifei1,2; Xin，Jingqi1; Deng，Caiting1; Tan，Xiaofang3,4; Aras，Omer5; Chen，Nandi2,6; Zhang，Xiaohong3; Ting，Richard2,7

2021-12-07

10.1039/d1tb01883c

Journal of Materials Chemistry B   影响因子和分区

2050-750X

2050-7518

Bodipy is one of the most popular dyes for bioimaging, however, a complicated synthetic protocol is needed to create and isolate ideal near-infrared (NIR) emissive Bodipy derivatives for optical bioimaging. It is noticed that the donor species impact the wavelength when the π-conjugation system of green light emissive Bodipy is elongatedviaa one-step reaction. Herein, several Bodipy dyes bearing different common donors are synthesized. Their optical properties confirm that both absorption and emission peaks of the synthesized Bodipy could be tuned to NIR wavelength by using stronger donorsviaa facile reaction. The synthesized monocarboxyl Bodipy could conjugate with aminated PEG to yield an amphiphilic polymer, which further self-assembles into a NIR nanoparticle (NP). The NIR NP exhibits preferential tumor accumulationviathe enhanced permeation and retention (EPR) effect, making it useful for tumor diagnosis by both fluorescence imaging and photoacoustic tomography.

SCI ; EI

英语

通讯

WOS:000712541200001

2-s2.0-85119982749

Scopus

1.Institute of Medical Engineering,Department of Biophysics,School of Basic Medical Science,Health Science Center,Xi’an Jiaotong University,Xi’an,No. 76 Yanta West Road,710061,China
2.Molecular Imaging Innovations Institute (MI3),Department of Radiology,Weill Cornell Medical College,New York,413 East 69th Street,10065,United States
3.Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices,Soochow University,Suzhou,215123,China
4.Jiangsu Institute of Marine Resources Development,Jiangsu Ocean University,Lianyungang,59 Cangwu Road,222005,China
5.Department of Radiology,Memorial Sloan Kettering Cancer Center,New York,10065,United States
6.Department of Gastrointestinal Surgery,Shenzhen People's Hospital (The Second Clinical Medicine College,Jinan University,First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,518020,China
7.Antelope Surgical,Biolabs@NYULangone,180 Varick St. Fl 6,New York,10014,United States

An，Feifei,Xin，Jingqi,Deng，Caiting,et al. Facile synthesis of near-infrared bodipy by donor engineering forin vivotumor targeted dual-modal imaging[J]. Journal of Materials Chemistry B,2021,9(45):9308-9315.

An，Feifei.,Xin，Jingqi.,Deng，Caiting.,Tan，Xiaofang.,Aras，Omer.,...&Ting，Richard.(2021).Facile synthesis of near-infrared bodipy by donor engineering forin vivotumor targeted dual-modal imaging.Journal of Materials Chemistry B,9(45),9308-9315.

An，Feifei,et al."Facile synthesis of near-infrared bodipy by donor engineering forin vivotumor targeted dual-modal imaging".Journal of Materials Chemistry B 9.45(2021):9308-9315.