Multimicrochannel Microneedle Microporation Platform for Enhanced Intracellular Drug Delivery

Lin, Long1,2; Wang, Yuqiong1; Cai, Minkun3; Jiang, Xinran1; Hu, Yongyan4; Dong, Zaizai1; Yin, Dedong1; Liu, Yilin5; Yang, Shaohua6,7; Liu, Zhiguang3; Zhuang, Jian2; Xu, Ye6,7; Guo, Chuan Fei3; Chang, Lingqian1

2021-12-01

10.1002/adfm.202109187

ADVANCED FUNCTIONAL MATERIALS   影响因子和分区

1616-301X

1616-3028

Common delivery routes for chemotherapeutics are based on circulation, which faces clinical limitations to local delivery efficiency, and the conflict between the dose for anticancer effect and the systemic toxicity. The recent advances in localized delivery strategies aim to improve drug accumulation at the target site or directly transport into cells. However, most are not equipped to provide additional momentum in the process of cargo release, propagation, and intracellular movement, which limit their locomotion that relies on passive diffusion. In this work, a multimicrochannel microneedle microporation (4M) platform that achieves high efficiency, safety, and uniformity for in vivo intracellular delivery is proposed. By high precision 3D printing, internal microchannels are implemented through the microneedle, which offer a concentrated, safe electric field that not only accelerates the movement of cargo into deep tissue under electrophoresis, but also triggers cell electroporation, achieving enhanced transport across cell membrane. The platform proves efficient for the delivery of chemotherapeutics in solid tumors in vitro and in vivo, with significantly enhanced anticancer effect and reduced systemic toxicity. The platform serves as a general-purpose delivery tool to emerging drugs in vivo.

chemotherapy drug delivery electroporation microchannels microneedles

SCI ; EI

英语

NI论文

通讯

National Natural Science Foundation of China[32071407,62003023,52073138,52003018,52003019] ; Beijing Natural Science Foundation[7212204]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000729406000001

WILEY-V C H VERLAG GMBH

20215011328357

3D printers ; Cells ; Controlled drug delivery ; Cytology ; Drug dosage ; Efficiency ; Electric fields ; Electrophoresis ; Microchannels ; Needles ; Targeted drug delivery ; Toxicity

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Health Care:461.7 ; Biology:461.9 ; Electricity: Basic Concepts and Phenomena:701.1 ; Printing Equipment:745.1.1 ; Colloid Chemistry:801.3 ; Electrochemistry:801.4.1 ; Production Engineering:913.1

MATERIALS SCIENCE

Web of Science

1.Beihang Univ, Sch Biol Sci & Med Engn, Beijing Adv Innovat Ctr Biomed Engn, Key Lab Biomech & Mechanobiol,Minist Educ, Beijing 100191, Peoples R China
2.Beijing Univ Chem Technol, Sch Mech & Elect Engn, Inst Plast Machinery & Plast Engn, Beijing 100029, Peoples R China
3.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China
4.Peking Univ First Hosp, Lab Anim Ctr, Beijing 100034, Peoples R China
5.Peking Union Med Coll Hosp, Dept Pathol, Beijing 100730, Peoples R China
6.Beihang Univ, Sch Mech Engn & Automat, Beijing 100191, Peoples R China
7.Beihang Univ, Ctr Soft Matter Phys & Its Applicat, Beijing 100191, Peoples R China

Lin, Long,Wang, Yuqiong,Cai, Minkun,et al. Multimicrochannel Microneedle Microporation Platform for Enhanced Intracellular Drug Delivery[J]. ADVANCED FUNCTIONAL MATERIALS,2021,32.

Lin, Long.,Wang, Yuqiong.,Cai, Minkun.,Jiang, Xinran.,Hu, Yongyan.,...&Chang, Lingqian.(2021).Multimicrochannel Microneedle Microporation Platform for Enhanced Intracellular Drug Delivery.ADVANCED FUNCTIONAL MATERIALS,32.

Lin, Long,et al."Multimicrochannel Microneedle Microporation Platform for Enhanced Intracellular Drug Delivery".ADVANCED FUNCTIONAL MATERIALS 32(2021).