Uptake and adverse reactions of COVID-19 vaccination among people living with HIV in China: a case-control study

Zhao, Heping1; Wang, Hui2,3; Li, Hui4; Zheng, Weiran1; Yuan, Tanwei1; Feng, Anping1; Luo, Dan1; Hu, Yuqing1; Sun, Yinghui1; Lin, Yi-Fan1; Zhou, Yiguo1; Luo, Ganfeng1; Peng, Qiaoli2,3; Yang, Jianzhou5; Xu, Junjie6; Zou, Huachun1,7,8

2021-12-01

10.1080/21645515.2021.1991183

Human Vaccines & Immunotherapeutics   影响因子和分区

2164-5515

2164-554X

Objectives The coronavirus disease-2019 (COVID-19) pandemic continues to ravage the world. People living with HIV (PLHIV) are one of the most vulnerable groups. This study aims to identify the factors associated with the uptake and adverse reactions of COVID-19 vaccination. Methods We recruited PLHIV in China by convenience sampling between 7 and 23 February 2021. Participants were asked to complete an online questionnaire. Chi-squared test and multivariable logistic regression were used to assess factors associated with vaccine uptake. Results A total of 527 vaccinated and 1091 unvaccinated PLHIV were recruited. Individuals who had a higher education, engaged in occupations with a higher risk of COVID-19 infection, received influenza or pneumonia vaccine in the past 3 years (5.40, 3.36-8.77), believed in the effectiveness of vaccines (3.01, 2.20-4.12), and received media information regarding COVID-19 vaccine (2.23, 1.61-3.11), were more likely to be vaccinated. Concerning about adverse reactions (0.31, 0.22-0.44), negative impact on the progression of HIV/AIDS (0.36, 0.26-0.50) or antiretroviral therapy (ART) (0.61, 0.44-0.85), disclosure of HIV infection status (0.69, 0.49-0.96), comorbidities (0.33, 0.22-0.47), being unmarried (0.43, 0.28-0.66) and older age were negatively associated with vaccination. Of the 527 vaccinated PLHIV, 155 (29.4%) PLHIV reported adverse reactions, with pain at the injection site being the most common (18.2%). Conclusions PLHIV, who are concerned about adverse reactions, negative impact on ART outcome and disclosure of HIV infection status, were less likely to adopt COVID-19 vaccination. To increase vaccination coverage among PLHIV, health-care professionals should emphasize the benefits and necessity of vaccination and provide consultancy regarding adverse reactions.

PLHIV COVID-19 vaccination vaccine uptake adverse reactions

SCI

英语

其他

Natural Science Foundation of China Excellent Young Scientists Fund[82022064] ; Natural Science Foundation of China International/Regional Research Collaboration Project[72061137001] ; Natural Science Foundation of China Young Scientist Fund[81703278] ; National Science and Technology Major Project of China[2018ZX10721102] ; Sanming Project of Medicine in Shenzhen[SZSM201811071] ; High Level Project of Medicine in Longhua, Shenzhen[HLPM201907020105] ; National Key Research and Development Program of China[JCYJ20190807155409373] ; Special Support Plan for High-Level Talents of Guangdong Province[2019TQ05Y230] ; Fundamental Research Funds for the Central Universities[58000-31620005] ; Science and Technology Innovation Committee of Shenzhen Municipality[JCYJ20170412151650600] ; Academic technology leader project of Changzhi Medical College[XSQ201902]

Biotechnology & Applied Microbiology ; Immunology

Biotechnology & Applied Microbiology ; Immunology

WOS:000729084100001

TAYLOR & FRANCIS INC

Web of Science

1.Sun Yat Sen Univ, Sch Publ Hlth Shenzhen, Shenzhen, Peoples R China
2.Southern Univ Sci & Technol, Natl Clin Res Ctr Infect Dis, PeopleS Hosp Shenzhen 3, Shenzhen, Guangdong, Peoples R China
3.Southern Univ Sci & Technol, Affiliated Hosp 2, Shenzhen, Guangdong, Peoples R China
4.Shizhong Dist Ctr Dis Control & Prevent, Jinan, Peoples R China
5.Changzhi Med Coll, Dept Prevent Med, Changzhi, Shanxi, Peoples R China
6.Peking Univ, Peking Univ Shenzhen Hosp, Clin Res Acad, Beijing, Peoples R China
7.Univ New South Wales, Kirby Inst, Sydney, NSW, Australia
8.Shanghai Jiao Tong Univ, Sch Publ Hlth, Shanghai, Peoples R China

Zhao, Heping,Wang, Hui,Li, Hui,et al. Uptake and adverse reactions of COVID-19 vaccination among people living with HIV in China: a case-control study[J]. Human Vaccines & Immunotherapeutics,2021.

Zhao, Heping.,Wang, Hui.,Li, Hui.,Zheng, Weiran.,Yuan, Tanwei.,...&Zou, Huachun.(2021).Uptake and adverse reactions of COVID-19 vaccination among people living with HIV in China: a case-control study.Human Vaccines & Immunotherapeutics.

Zhao, Heping,et al."Uptake and adverse reactions of COVID-19 vaccination among people living with HIV in China: a case-control study".Human Vaccines & Immunotherapeutics (2021).