The power of genetic diversity in genome-wide association studies of lipids

Graham, Sarah E.1; Clarke, Shoa L.2,3; Wu, Kuan-Han H.4; Kanoni, Stavroula5; Zajac, Greg J. M.6,7; Ramdas, Shweta8; Surakka, Ida1; Ntalla, Ioanna9; Vedantam, Sailaja10,11; Winkler, Thomas W.12; Locke, Adam E.13,14; Marouli, Eirini5; Hwang, Mi Yeong15; Han, Sohee15; Narita, Akira16; Choudhury, Ananyo17; Bentley, Amy R.18; Ekoru, Kenneth18; Verma, Anurag8; Trivedi, Bhavi19; Martin, Hilary C.20; Hunt, Karen A.19; Hui, Qin21,22; Klarin, Derek23,24,25; Zhu, Xiang2,26,27,28; Thorleifsson, Gudmar29; Helgadottir, Anna29; Gudbjartsson, Daniel F.29,30; Holm, Hilma29; Olafsson, Isleifur31; Akiyama, Masato32,33; Sakaue, Saori32,34,35; Terao, Chikashi36; Kanai, Masahiro25,32,37; Zhou, Wei4,38,39; Brumpton, Ben M.40,41,42; Rasheed, Humaira40,41; Ruotsalainen, Sanni E.43; Havulinna, Aki S.43,44; Veturi, Yogasudha45; Feng, QiPing46; Rosenthal, Elisabeth A.47; Lingren, Todd48; Pacheco, Jennifer Allen49; Pendergrass, Sarah A.50; Haessler, Jeffrey51; Giulianini, Franco52; Bradford, Yuki45; Miller, Jason E.45; Campbell, Archie53,54; Lin, Kuang55,56; Millwood, Iona Y.55,56,57; Hindy, George58; Rasheed, Asif59; Faul, Jessica D.60; Zhao, Wei61; Weir, David R.60; Turman, Constance62; Huang, Hongyan62; Graff, Mariaelisa63; Mahajan, Anubha64; Brown, Michael R.65; Zhang, Weihua66,67,68; Yu, Ketian69; Schmidt, Ellen M.69; Pandit, Anita69; Gustafsson, Stefan70; Yin, Xianyong69; Luan, Jian'an71; Zhao, Jing-Hua72; Matsuda, Fumihiko73; Jang, Hye-Mi15; Yoon, Kyungheon15; Medina-Gomez, Carolina74,75; Pitsillides, Achilleas76; Hottenga, Jouke Jan77,78; Willemsen, Gonneke77,79; Wood, Andrew R.80; Ji, Yingji80; Gao, Zishan81,82,83; Haworth, Simon41,84; Mitchell, Ruth E.41,85; Chai, Jin Fang86,87; Aadahl, Mette88; Yao, Jie89; Manichaikul, Ani90; Warren, Helen R.91,92; Ramirez, Julia91; Bork-Jensen, Jette93; Karhus, Line L.88; Goel, Anuj64,94; Sabater-Lleal, Maria95,96; Noordam, Raymond97; Sidore, Carlo98; Fiorillo, Edoardo99; McDaid, Aaron F.100,101; Marques-Vidal, Pedro102,103; Wielscher, Matthias104; Trompet, Stella97,105; Sattar, Naveed106; Mollehave, Line T.88; Thuesen, Betina H.88; Munz, Matthias107,108,109,110,111,112; Zeng, Lingyao111,112,113; Huang, Jianfeng114,115; Yang, Bin114,115; Poveda, Alaitz116; Kurbasic, Azra116; Lamina, Claudia117,118; Forer, Lukas117,118; Scholz, Markus119,120; Galesloot, Tessel E.121; Bradfield, Jonathan P.122; Daw, E. Warwick123; Zmuda, Joseph M.124; Mitchell, Jonathan S.125; Fuchsberger, Christian125; Christensen, Henry126; Brody, Jennifer A.127; Feitosa, Mary F.123; Wojczynski, Mary K.123; Preuss, Michael128; Mangino, Massimo129,130; Christofidou, Paraskevi129; Verweij, Niek131; Benjamins, Jan W.131; Engmann, Jorgen132,133; Kember, Rachel L.134; Slieker, Roderick C.135,136; Lo, Ken Sin137; Zilhao, Nuno R.138; Phuong Le139; Kleber, Marcus E.140,141; Delgado, Graciela E.140; Huo, Shaofeng142; Ikeda, Daisuke D.143; Iha, Hiroyuki143; Yang, Jian144,145; Liu, Jun146; Leonard, Hampton L.147,148; Marten, Jonathan149; Schmidt, Borge150; Arendt, Marina150,151; Smyth, Laura J.152; Canadas-Garre, Marisa152; Wang, Chaolong153,154; Nakatochi, Masahiro155; Wong, Andrew156; Hutri-Kahonen, Nina157,158; Sim, Xueling86,87; Xia, Rui159; Huerta-Chagoya, Alicia160; Fernandez-Lopez, Juan Carlos161; Lyssenko, Valeriya116,162; Ahmed, Meraj163; Jackson, Anne U.6,7; Irvin, Marguerite R.164; Oldmeadow, Christopher165; Kim, Han-Na166,167; Ryu, Seungho168,169; Timmers, Paul R. H. J.149,170; Arbeeva, Liubov171; Dorajoo, Rajkumar154; Lange, Leslie A.172; Chai, Xiaoran87,173,174; Prasad, Gauri175,176; Lores-Motta, Laura177; Pauper, Marc177; Long, Jirong178; Li, Xiaohui89; Theusch, Elizabeth179; Takeuchi, Fumihiko180; Spracklen, Cassandra N.181,182; Loukola, Anu43; Bollepalli, Sailalitha43; Warner, Sophie C.183,184; Wang, Ya Xing185,186; Wei, Wen B.186; Nutile, Teresa187; Ruggiero, Daniela187,188; Sung, Yun Ju189; Hung, Yi-Jen190; Chen, Shufeng114,115; Liu, Fangchao114,115; Yang, Jingyun191,192; Kentistou, Katherine A.170; Gorski, Mathias12,193; Brumat, Marco194; Meidtner, Karina195,196; Bielak, Lawrence F.61; Smith, Jennifer A.60,61; Hebbar, Prashantha197; Farmaki, Aliki-Eleni198,199; Hofer, Edith200,201; Lin, Maoxuan202; Xue, Chao1; Zhang, Jifeng1; Concas, Maria Pina203; Vaccargiu, Simona204; van der Most, Peter J.205; Pitkanen, Niina206,207,208; Cade, Brian E.209,210; Lee, Jiwon209; van Der Laan, Sander W.211; Chitrala, Kumaraswamy Naidu212; Weiss, Stefan213; Zimmermann, Martina E.12; Lee, Jong Young214; Choi, Hyeok Sun215; Nethander, Maria216,217; Freitag-Wolf, Sandra218; Southam, Lorraine219,220; Rayner, Nigel W.20,64,219,221; Wang, Carol A.222; Lin, Shih-Yi223,224,225; Wang, Jun-Sing226,227; Couture, Christian228; Lyytikainen, Leo-Pekka229,230; Nikus, Kjell231,232; Cuellar-Partida, Gabriel233; Vestergaard, Henrik93,234; Hildalgo, Bertha235; Giannakopoulou, Olga5; Cai, Qiuyin178; Obura, Morgan O.135; van Setten, Jessica236; Li, Xiaoyin237; Schwander, Karen123; Terzikhan, Natalie75; Shin, Jae Hun215; Jackson, Rebecca D.238; Reiner, Alexander P.239; Martin, Lisa Warsinger240; Chen, Zhengming55,56,57; Li, Liming241; Highland, Heather M.63; Young, Kristin L.63; Kawaguchi, Takahisa73; Thiery, Joachim120,242; Bis, Joshua C.127; Nadkarni, Girish N.128; Launer, Lenore J.243; Li, Huaixing142; Nalls, Mike A.147,148; Raitakari, Olli T.206,207,208,244; Ichihara, Sahoko245; Wild, Sarah H.246; Nelson, Christopher P.183,184; Campbell, Harry170; Jager, Susanne195,196; Nabika, Toru247; Al-Mulla, Fahd197; Niinikoski, Harri248,249,250; Braund, Peter S.183,184; Kolcic, Ivana251; Kovacs, Peter252; Giardoglou, Tota253; Katsuya, Tomohiro254,255; Bhatti, Fatima5; de Kleijn, Dominique256; de Borst, Gert J.256; Kim, Eung Kweon257; Adams, Hieab H. H.75,258; Ikram, M. Arfan75; Zhu, Xiaofeng237; Asselbergs, Folkert W.236; Kraaijeveld, Adriaan O.236; Beulens, Joline W. J.135,259; Shu, Xiao-Ou178; Rallidis, Loukianos S.260; Pedersen, Oluf93; Hansen, Torben93; Mitchell, Paul261,262; Hewitt, Alex W.263,264; Kahonen, Mika265,266; Perusse, Louis228,267; Bouchard, Claude268; Tonjes, Anke252; Chen, Yii-Der Ida89; Pennell, Craig E.222; Mori, Trevor A.269; Lieb, Wolfgang270; Franke, Andre271; Ohlsson, Claes216,272; Mellstrom, Dan216,273; Cho, Yoon Shin215; Lee, Hyejin274; Yuan, Jian-Min275,276; Koh, Woon-Puay277,278; Rhee, Sang Youl279; Woo, Jeong-Taek279; Heid, Iris M.12; Stark, Klaus J.12; Volzke, Henry280; Homuth, Georg213; Evans, Michele K.212; Zonderman, Alan B.212; Polasek, Ozren251; Pasterkamp, Gerard211; Hoefer, Imo E.211; Redline, Susan209,210; Pahkala, Katja206,207,208,281; Oldehinkel, Albertine J.282; Snieder, Harold205; Biino, Ginevra283; Schmidt, Reinhold200; Schmidt, Helena284; Chen, Y. Eugene1; Bandinelli, Stefania285; Dedoussis, George198; Thanaraj, Thangavel Alphonse197; Kardia, Sharon L. R.61; Kato, Norihiro180; Schulze, Matthias B.195,196,286; Girotto, Giorgia194,203; Jung, Bettina193; Boger, Carsten A.193,287,288; Joshi, Peter K.170; Bennett, David A.191,192; De Jager, Philip L.289,290; Lu, Xiangfeng114,115; Mamakou, Vasiliki291,292; Brown, Morris92,293; Caulfield, Mark J.91,92; Munroe, Patricia B.91,92; Guo, Xiuqing89; Ciullo, Marina187,188; Jonas, Jost B.294,295,296; Samani, Nilesh J.183,184; Kaprio, Jaakko43; Pajukanta, Paivi298; Adair, Linda S.305,306; Bechayda, Sonny Augustin307,308; de Silva, H. Janaka309; Wickremasinghe, Ananda R.310; Krauss, Ronald M.311,312; Wu, Jer-Yuarn313; Zheng, Wei178; den Hollander, Anneke, I177; Bharadwaj, Dwaipayan176,314; Correa, Adolfo315; Wilson, James G.316; Lind, Lars317; Heng, Chew-Kiat318,319; Nelson, Amanda E.171,320; Golightly, Yvonne M.171,321,322,323; Wilson, James F.149,170; Penninx, Brenda79,324; Kim, Hyung-Lae325; Attia, John165,326; Scott, Rodney J.165,326; Rao, D. C.327; Arnett, Donna K.328; Walker, Mark329; Koistinen, Heikki A.330,331,332,333; Chandak, Giriraj R.163,334; Yajnik, Chittaranjan S.335; Mercader, Josep M.297,336,337; Tusie-Luna, Teresa299,300,301; Aguilar-Salinas, Carlos A.302,303,304; Villalpando, Clicerio Gonzalez338,339; Orozco, Lorena340; Fornage, Myriam159,341; Tai, E. Shyong86,87,342; van Dam, Rob M.86,87,342; Lehtimaki, Terho229,230; Chaturvedi, Nish156; Yokota, Mitsuhiro343; Liu, Jianjun154; Reilly, Dermot F.344; McKnight, Amy Jayne152; Kee, Frank152; Jockel, Karl-Heinz150; McCarthy, Mark, I50,64,345; Palmer, Colin N. A.346; Vitart, Veronique149; Hayward, Caroline149; Simonsick, Eleanor347; van Duijn, Cornelia M.146; Lu, Fan348; Qu, Jia348; Hishigaki, Haretsugu143; Lin, Xu142; Marz, Winfried140,349,350; Parra, Esteban J.139; Cruz, Miguel351; Gudnason, Vilmundur138,352; Tardif, Jean-Claude137,353; Lettre, Guillaume137,354; 't Hart, Leen M.135,136,355; Elders, Petra J. M.356; Damrauer, Scott M.359,360; Kumari, Meena361; Kivimaki, Mika133; van der Harst, Pim131; Spector, Tim D.129; Loos, Ruth J. F.128,362; Province, Michael A.123; Psaty, Bruce M.363,364; Brandslund, Ivan126,365; Pramstaller, Peter P.125; Christensen, Kaare366; Ripatti, Samuli43,117,367,368; Widen, Elisabeth43; Hakonarson, Hakon369,370; Grant, Struan F. A.357,370,371; Kiemeney, Lambertus A. L. M.121; de Graaf, Jacqueline121; Loeffler, Markus119,120; Kronenberg, Florian117,118; Gu, Dongfeng114,115,372; Erdmann, Jeanette373,374; Schunkert, Heribert112,375; Franks, Paul W.116; Linneberg, Allan88,376; Jukema, J. Wouter105,377; Khera, Amit, V98,290,337,378,379; Mannikko, Minna380; Jarvelin, Marjo-Riitta104,381,382; Kutalik, Zoltan101,383; Cucca, Francesco98,384; Mook-Kanamori, Dennis O.385,386; van Dijk, Ko Willems387,388,389; Watkins, Hugh64,390; Strachan, David P.391; Grarup, Niels93; Sever, Peter392; Poulter, Neil393; Rotter, Jerome, I89; Dantoft, Thomas M.88; Karpe, Fredrik394,395; Neville, Matt J.394,395; Timpson, Nicholas J.41,85; Cheng, Ching-Yu173,396; Wong, Tien-Yin173,396; Khor, Chiea Chuen154; Sabanayagam, Charumathi173,396; Peters, Annette83,196,397; Gieger, Christian82,83,196; Hattersley, Andrew T.398; Pedersen, Nancy L.399; Magnusson, Patrik K. E.399; Boomsma, Dorret, I77,78,400; de Geus, Eco J. C.77,79; Cupples, L. Adrienne76,401; van Meurs, Joyce B. J.74,75; Ghanbari, Mohsen75,402; Rsen, Penny Gordon-La305,306; Huang, Wei403; Kim, Young Jin15; Tabara, Yasuharu73; Wareham, Nicholas J.71; Langenberg, Claudia71; Zeggini, Eleftheria219,220,404,405; Kuusisto, Johanna406,407; Laakso, Markku406,407; Ingelsson, Erik3,70,408,409; Abecasis, Goncalo69,410; Chambers, John C.66,67,411,412; Kooner, Jaspal S.67,68,392,413; de Vries, Paul S.65; Morrison, Alanna C.65; North, Kari E.63; Daviglus, Martha414; Kraft, Peter62,415; Martin, Nicholas G.416; Whitfield, John B.416; Abbas, Shahid59,417; Saleheen, Danish59,418,419; Walters, Robin G.55,56,57,420; Holmes, Michael, V55,56,57,421; Black, Corri422; Smith, Blair H.423; Justice, Anne E.424; Baras, Aris410; Buring, Julie E.52,297; Ridker, Paul M.52,297; Chasman, Daniel, I52,297; Kooperberg, Charles51; Wei, Wei-Qi425; Jarvik, Gail P.426; Namjou, Bahram427; Hayes, M. 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2021-12-01

10.1038/s41586-021-04064-3

NATURE   影响因子和分区

0028-0836

1476-4687

Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use(1). Despite advances in prevention and treatment, in particular through reducing low-density lipoprotein cholesterol levels(2), heart disease remains the leading cause of death worldwide(3). Genome-wideassociation studies (GWAS) of blood lipid levels have led to important biological and clinical insights, as well as new drug targets, for cardiovascular disease. However, most previous GWAS(4-23) have been conducted in European ancestry populations and may have missed genetic variants that contribute to lipid-level variation in other ancestry groups. These include differences in allele frequencies, effect sizes and linkage-disequilibrium patterns(24). Here we conduct a multi-ancestry, genome-wide genetic discovery meta-analysis of lipid levels in approximately 1.65 million individuals, including 350,000 of non-European ancestries. We quantify the gain in studying non-European ancestries and provide evidence to support the expansion of recruitment of additional ancestries, even with relatively small sample sizes. We find that increasing diversity rather than studying additional individuals of European ancestry results in substantial improvements in fine-mapping functional variants and portability of polygenic prediction (evaluated in approximately 295,000 individuals from 7 ancestry groupings). Modest gains in the number of discovered loci and ancestry-specific variants were also achieved. As GWAS expand emphasis beyond the identification of genes and fundamental biology towards the use of genetic variants for preventive and precision medicine(25), we anticipate that increased diversity of participants will lead to more accurate and equitable(26) application of polygenic scores in clinical practice.

SCI

英语

NI论文 ; ESI热点 ; ESI高被引

其他

NIH[R01-HL127564] ; Office of Research and Development, Veterans Health Administration["2I01BX003362-03A1","1I01BX004821-01A1"]

Science & Technology - Other Topics

Multidisciplinary Sciences

WOS:000728504500001

NATURE PORTFOLIO

BIOLOGY & BIOCHEMISTRY;CLINICAL MEDICINE;MULTIDISCIPLINARY;PLANT & ANIMAL SCIENCE;ENVIRONMENT/ECOLOGY;SOCIAL SCIENCES, GENERAL;MICROBIOLOGY;ECONOMICS BUSINESS;IMMUNOLOGY;MATERIALS SCIENCE;COMPUTER SCIENCE;SPACE SCIENCE;MOLECULAR BIOLOGY & GENETICS;CHEMISTRY;NEUROSCIENCE & BEHAVIOR;PHYSICS;GEOSCIENCES;ENGINEERING

Web of Science

1.Univ Michigan, Dept Internal Med, Div Cardiol, Ann Arbor, MI 48109 USA
2.VA Palo Alto Hlth Care Syst, Palo Alto, CA 94304 USA
3.Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA
4.Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA
5.Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England
6.Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA
7.Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA
8.Univ Penn, Perelman Sch Med, Dept Genet, Philadelphia, PA 19104 USA
9.Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, Clin Pharmacol, London, England
10.Boston Childrens Hosp, Endocrinol, Boston, MA USA
11.Broad Inst, Med & Populat Genet, Cambridge, MA USA
12.Univ Regensburg, Dept Genet Epidemiol, Regensburg, Germany
13.Washington Univ, McDonnell Genome Inst, St Louis, MO 63110 USA
14.Washington Univ, Dept Med, St Louis, MO USA
15.Natl Inst Hlth, Dept Precis Med, Div Genome Sci, Cheongju, South Korea
16.Tohoku Univ, Tohoku Med Megabank Org, Sendai, Miyagi, Japan
17.Univ Witwatersrand, Fac Hlth Sci, Sydney Brenner Inst Mol Biosci, Johannesburg, South Africa
18.NHGRI, Ctr Res Genom & GLobal Hearth, NIH, Bethesda, MD 20892 USA
19.Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England
20.Wellcome Sanger Inst, Hinxton, England
21.Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA
22.Atlanta VA Hlth Care Syst, Decatur, GA USA
23.Malcolm Randall VA Med Ctr, Gainesville, FL USA
24.Univ Florida, Coll Med, Div Vasc Surg & Endovasc Therapy, Gainesville, FL USA
25.Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA
26.Penn State Univ, Dept Stat, University Pk, PA 16802 USA
27.Penn State Univ, Huck Inst Life Sci, University Pk, PA 16802 USA
28.Stanford Univ, Dept Stat, Stanford, CA 94305 USA
29.Amgen Inc, deCODE Genet, Reykjavik, Iceland
30.Univ Iceland, Sch Engn & Nat Sci, Reykjavik, Iceland
31.Natl Univ Hosp Iceland, Dept Clin Biochem, Landspitali, Reykjavik, Iceland
32.RIKEN, Lab Stat Anal, Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan
33.Kyushu Univ, Grad Sch Med Sci, Dept Ophthalmol, Fukuoka, Japan
34.Osaka Univ, Dept Stat Genet, Grad Sch Med, Osaka, Japan
35.Univ Tokyo, Grad Sch Med, Dept Allergy & Rheumatol, Tokyo, Japan
36.RIKEN, Lab Stat & Translat Genet, Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan
37.Harvard Med Sch, Dept Biomed Informat, Boston, MA 02115 USA
38.Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA
39.Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA
40.Norwegian Univ Sci & Technol, KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, NTNU, Trondheim, Norway
41.Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England
42.Trondheim Reg & Univ Hosp, Dept Thorac Med, St Olavs Hosp, Trondheim, Norway
43.Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Helsinki, Finland
44.Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland
45.Univ Penn, Inst Biomed Informat, Dept Genet, Perelman Sch Med, Philadelphia, PA 19104 USA
46.Vanderbilt Univ Sch Med, Dept Med, Div Clin Pharmacol, Nashville, TN USA
47.Univ Washington, Dept Med Med Genet, Seattle, WA 98195 USA
48.Cincinnati Childrens Hosp Med Ctr, Div Biomed Informat, Cincinnati, OH 45229 USA
49.Northwestern Univ, Ctr Genet Med, Evanston, IL USA
50.Genentech Inc, San Francisco, CA 94080 USA
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52.Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA
53.Univ Edinburgh, Western Gen Hosp, Ctr Genom & Expt Med, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland
54.Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland
55.Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England
56.Univ Oxford, Nuffield Dept Populat Hearth, Epidemiol Studies Unit, Oxford, England
57.Univ Oxford, Med Res Council Populat Hlth Res Unit, Nuffield Dept Populat Hlth, Oxford, England
58.Qatar Univ, Dept Populat Med, QU Hlth, Coll Med, Doha, Qatar
59.Ctr Noncommunicable Dis, Karachi, Pakistan
60.Univ Michigan, Inst Social Res, Survey Res Ctr, Ann Arbor, MI USA
61.Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
62.Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Program Genet Epidemiol & Stat Genet, Boston, MA USA
63.Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA
64.Univ Oxford, Wellcome Ctr Human Genet, Oxford, England
65.Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Dept Epidemiol, Sch Publ Hlth, Houston, TX 77030 USA
66.Imperial Coll London, Dept Epidemiol & Biostat, London, England
67.London North West Univ Healthcare NHS Trust, Ealing Hosp, Dept Cardiol, Southall, Middx, England
68.Imperial Coll Healthcare NHS Trust, London, England
69.Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA
70.Uppsala Univ, Dept Med Sci, Mol Epidemiol & Sci Life Lab, Uppsala, Sweden
71.Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England
72.Univ Cambridge, Dept Publ Hlth & Primary Care, Cardiovasc Epidemiol Unit, Strangeways Res Lab, Cambridge, England
73.Kyoto Univ, Ctr Genom Med, Grad Sch Med, Kyoto, Japan
74.Univ Med Ctr Rotterdam, Dept Internal Med, Erasmus MC, Rotterdam, Netherlands
75.Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands
76.Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA
77.Vrije Univ Amsterdam, Dept Biol Psychol Behav & Movement Sci, Amsterdam, Netherlands
78.VU Med Ctr Amsterdam, Amsterdam Publ Hlth, Amsterdam, Netherlands
79.VU Med Ctr Amsterdam, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands
80.Univ Exeter, Univ Exeter Med Sch, Genet Complex Traits, Exeter, Devon, England
81.Nanjing Univ Chinese Med, Dept Clin Acupuncture & Moxibust, Nanjing, Peoples R China
82.Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany
83.Helmholtz Zentrum Munchen, Inst Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany
84.Univ Bristol, Bristol Dent Sch, Bristol, Avon, England
85.Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England
86.Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore
87.Natl Univ Hlth Syst, Singapore, Singapore
88.Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Copenhagen, Denmark
89.Harbor UCLA Med Ctr, Lundquist Inst Biomed Innovat, LABioMed, Inst Translat Genom & Populat Sci,Dept Pediat, Torrance, CA 90509 USA
90.Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA
91.Queen Mary Univ London, John Vane Sci Ctr, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England
92.Queen Mary Univ London, NIHR Barts Cardiovasc Biomed Res Ctr, Barts & London Sch Med & Dent, London, England
93.Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, Copenhagen, Denmark
94.Univ Oxford, John Radcliffe Hosp, Radcliffe Dept Med, Div Cardiovasc Med, Oxford, England
95.Hosp Santa Creu & St Pau IIB St Pau, Grp Genom Complex Dis, Res Inst, Barcelona, Spain
96.Karolinska Univ Hosp, Ctr Mol Med, Karolinska Inst, Dept Med,Cardiovasc Med Unit, Stockholm, Sweden
97.Leiden Univ Med Ctr, Dept Internal Med, Sect Gerontol & Geriatr, Leiden, Netherlands
98.Italian Natl Council Res IRGB CNR, Inst Genet & Biomed Res, Cagliari, Italy
99.Italian Natl Council Res IRGB CNR, Inst Genet & Biomed Res, Lanusei, Italy
100.Univ Lausanne, Univ Ctr Primary Care & Publ Hlth, Lausanne, Switzerland
101.Swiss Inst Bioinformat, Lausanne, Switzerland
102.Lausanne Univ Hosp, Dept Med, Internal Med, Lausanne, Switzerland
103.Univ Lausanne, Lausanne, Switzerland
104.Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England
105.Leiden Univ Med Ctr, Dept Cardiol, Leiden, Netherlands
106.BHF Glasgow Cardiovasc Res Ctr, Fac Med, Glasgow, Lanark, Scotland
107.Univ Lubeck, Univ Heart Ctr Lubeck, DZHK German Res Ctr Cardiovasc Res, Inst Cardiogenet,Partner Site Hamburg Lubeck Kiel, Lubeck, Germany
108.Charite Univ Med Berlin, Berlin, Germany
109.Free Univ Berlin, Berlin, Germany
110.Humboldt Univ, Berlin, Germany
111.Berlin Inst Hlth, Inst Dent & Craniofacial Sci, Dept Periodontol & Synopt Dent, Berlin, Germany
112.Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany
113.Deutsch Zentrum Herz Kreislauf Forsch DZHK, Partner Site Munich Heart Alliance, Munich, Germany
114.Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Key Lab Cardiovasc Epidemiol,State Key Lab Cardio, Beijing, Peoples R China
115.Chinese Acad Med Sci & Peking Union Med Coll, Natl Ctr Cardiovasc Dis, Fuwai Hosp, State Key Lab Cardiovasc Dis,Dept Epidemiol, Beijing, Peoples R China
116.Lund Univ, Diabet Ctr, Malmo, Sweden
117.Med Univ Innsbruck, Inst Genet Epidemiol, Dept Genet & Pharmacol, Innsbruck, Austria
118.German Chron Kidney Dis Study, Innsbruck, Austria
119.Univ Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany
120.Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany
121.Radboud Univ Nijmegen, Med Ctr, Radboud Inst Hlth Sci, Nijmegen, Netherlands
122.Quantinuum Res, Wayne, PA USA
123.Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA
124.Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA
125.Univ Lubeck, Affiliated Inst, Eurac Res, Inst Biomed, Bolzano, Italy
126.Lillebaelt Hosp, Dept Clin Biochem, Vejle, Denmark
127.Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA
128.Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA
129.Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England
130.Guys & St Thomas Fdn Trust, NIHR Biomed Res Ctr, London, England
131.Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands
132.UCL, Inst Cardiovasc Sci, London, England
133.UCL, Dept Epidemiol & Publ Hlth, London, England
134.Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA
135.Amsterdam UMC, Dept Epidemiol & Biostat, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands
136.Leiden Univ Med Ctr, Dept Cell & Chem Biol, Leiden, Netherlands
137.Montreal Heart Inst, Montreal, PQ, Canada
138.Iceland Heart Assoc, Reykjavik, Iceland
139.Univ Toronto Mississauga, Dept Anthropol, Mississauga, ON, Canada
140.Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Mannheim, Germany
141.Synlab MVZ Humangenet Mannheim, Mannheim, Germany
142.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Shanghai, Peoples R China
143.Otsuka Pharmaceut Co Ltd, Tokushima Res Inst, Biomed Technol Res Ctr, Tokushima, Japan
144.Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia
145.Wenzhou Med Univ, Inst Adv Res, Wenzhou, Peoples R China
146.Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England
147.NIA, Lab Neurogenet, NIH, Bethesda, MD 20892 USA
148.Data Tecn Int, Glen Echo, MD USA
149.Univ Edinburgh, Western Gen Hosp, Inst Genet & Canc, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland
150.Univ Duisburg Essen, Inst Med Informat Biometrie & Epidemiol, Essen, Germany
151.Univ Appl Sci & Arts Dortmund, Dept Comp Sci, Dortmund, Germany
152.Queens Univ Belfast, Ctr Publ Hlth, Belfast, Antrim, North Ireland
153.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan, Peoples R China
154.Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore
155.Nagoya Univ, Dept Integrated Hlth Sci, Publ Hlth Informat Unit, Grad Sch Med, Nagoya, Aichi, Japan
156.UCL, MRC Unit Lifelong Hlth & Ageing, London, England
157.Tampere Univ Hosp, Dept Pediat, Tampere, Finland
158.Tampere Univ, Fac Med & Hlth Technol, Dept Pediat, Tampere, Finland
159.Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Brown Fdn Inst Mol Med, Houston, TX 77030 USA
160.UNAM, Dept Med Genom & Toxicol Ambiental, Inst Invest Biomed, Ciudad De Mexico, Mexico
161.Inst Nacl Med Genom, Dept Genom Computac, Ciudad De Mexico, Mexico
162.Univ Bergen, Ctr Diabet Res, Bergen, Norway
163.CSIR Ctr Cellular & Mol Biol, Genom Res Complex Dis GRC Grp, Hyderabad, India
164.Univ Alabama Birmingham, Sch Publ Hlth, Epidemiol, Birmingham, AL 35294 USA
165.Hunter Med Res Inst, Newcastle, NSW, Australia
166.Sungkyunkwan Univ, Kangbuk Samsung Hosp, Med Res Inst, Sch Med, Seoul, South Korea
167.Sungkyunkwan Univ, Dept Clin Res Design & Evaluat, SAIHST, Seoul, South Korea
168.Sungkyunkwan Univ, Kangbuk Samsung Hosp, Ctr Cohort Studies, Total Healthcare Ctr,Sch Med, Seoul, South Korea
169.Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Occupat & Environm Med, Sch Med, Seoul, South Korea
170.Univ Edinburgh, Ctr Global Hlth Res, Usher Inst, Edinburgh, Midlothian, Scotland
171.Univ N Carolina, Thurston Arthrit Res Ctr, Chapel Hill, NC USA
172.Univ Colorado, Dept Med, Div Biomed Informat & Personalized Med, Anschutz Med Campus, Aurora, CO USA
173.Singapore Natl Eye Ctr, Singapore Eye Res Inst, Ocular Epidemiol, Singapore, Singapore
174.Natl Univ Singapore, Dept Ophthalmol, Singapore, Singapore
175.CSIR, Genom & Mol Med Unit, Inst Genom & Integrat Biol, New Delhi, India
176.Acad Sci & Innovat Res, CSIR Inst Genom & Integrat Biol Campus, New Delhi, India
177.Radboud Univ Nijmegen, Dept Ophthalmol, Med Ctr, Nijmegen, Netherlands
178.Vanderbilt Univ Sch Med, Vanderbilt Epidemiol Ctr, Div Epidemiol, Nashville, TN USA
179.Univ Calif San Francisco, Dept Pediat, Oakland, CA USA
180.Natl Ctr Global Hlth & Med, Tokyo, Japan
181.Univ N Carolina, Dept Genet, Chapel Hill, NC USA
182.Univ Massachusetts, Dept Biostat & Epidemiol, Amherst, MA 01003 USA
183.Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England
184.Glenfield Hosp, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England
185.Beijing Inst Ophthalmol, Beijing Key Lab Ophthalmol & Visual Sci, Beijing, Peoples R China
186.Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing, Peoples R China
187.CNR, Inst Genet & Biophys Adriano Buzzati Traverso, Naples, Italy
188.IRCCS Neuromed, Pozzilli, Isernia, Italy
189.Washington Univ, Dept Psychiat, St Louis, MO 63110 USA
190.Triserv Gen Hosp, Div Endocrinol & Metab, Songshan Branch, Taipei, Taiwan
191.Rush Univ Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL USA
192.Rush Univ Med Ctr, Dept Neurol Sci, Chicago, IL USA
193.Univ Hosp Regensburg, Dept Nephrol, Regensburg, Germany
194.Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy
195.German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany
196.German Ctr Diabet Res DZD, Neuherberg, Germany
197.Dasman Diabet Inst, Dept Genet & Bioinformat, Kuwait, Kuwait
198.Harokopio Univ Athens, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece
199.UCL, Dept Populat Sci & Expt Med, London, England
200.Med Univ Graz, Dept Neurol, Clin Div Neurogeriatr, Graz, Austria
201.Med Univ Graz, Inst Med Informat Stat & Documentat, Graz, Austria
202.Univ N Carolina, Dept Bioinformat & Genom, Charlotte, NC USA
203.IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy
204.UOS Sassari, Natl Res Council Italy, Inst Genet & Biomed Res, Sassari, Italy
205.Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands
206.Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland
207.Univ Turku, Ctr Populat Hlth Res, Turku, Finland
208.Turku Univ Hosp, Turku, Finland
209.Brigham & Womens Hosp, Sleep Med & Circadian Disorders, 75 Francis St, Boston, MA 02115 USA
210.Harvard Med Sch, Div Sleep Med, Boston, MA 02115 USA
211.Univ Utrecht, Univ Med Ctr Utrecht, Div Labs Pharm & Biomed Genet, Cent Diagnost Lab, Utrecht, Netherlands
212.NIA, Lab Epidemiol & Populat Sci, Intramural Res Program, NIH,Biomed Res Ctr, Baltimore, MD 21224 USA
213.Univ Greifswald, Interfac Inst Genet & Funct Genom, Dept Funct Genom, Greifswald, Germany
214.Oneomics, Bucheon, South Korea
215.Hallym Univ, Dept Biomed Sci, Chunchon, South Korea
216.Univ Gothenburg, Sahlgrenska Acad, Ctr Bone & Arthrit Res, Inst Med, Gothenburg, Sweden
217.Univ Gothenburg, Sahlgrenska Acad, Bioinformat Core Facil, Gothenburg, Sweden
218.Univ Kiel, Inst Med Informat & Stat, Kiel, Germany
219.Helmholtz Zentrum Munchen, Inst Translat Genom, German Res Ctr Environm Hlth, Neuherberg, Germany
220.Wellcome Trust Sanger Inst, Hinxton, England
221.Oxford Ctr Diabet Endocrinol & Metab, Oxford, England
222.Univ Newcastle, Coll Hlth Med & Wellbeing, Sch Med & Publ Hlth, Newcastle, NSW, Australia
223.Taichung Vet Gen Hosp, Ctr Geriatr & Gerontol, Dept Internal Med, Div Endocrinol & Metab, Taichung, Taiwan
224.Natl Yang Ming Univ, Sch Med, Taipei, Taiwan
225.Natl Def Med Ctr, Sch Med, Taipei, Taiwan
226.Taichung Vet Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, Taichung, Taiwan
227.Natl Yang Ming Univ, Sch Med, Dept Med, Taipei, Taiwan
228.Univ Laval, Dept Kinesiol, Laval, PQ, Canada
229.Fimlab Labs, Dept Clin Chem, Tampere, Finland
230.Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Chem, Tampere, Finland
231.Tampere Univ Hosp, Heart Ctr, Dept Cardiol, Tampere, Finland
232.Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Cardiol, Tampere, Finland
233.Univ Queensland, Translat Res Inst, Diamantina Inst, Brisbane, Qld, Australia
234.Bornholms Hosp, Dept Med, Ronne, Denmark
235.Univ Alabama Birmingham, Sch Publ Hlth, Birmingham, AL 35294 USA
236.Univ Utrecht, Univ Med Ctr Utrecht, Div Heart & Lungs, Cardiol, Utrecht, Netherlands
237.Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA
238.Ohio State Univ, Div Endocrinol, Columbus, OH 43210 USA
239.Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA
240.George Washington Univ, Sch Med & Hlth Sci, Washington, DC 20052 USA
241.Peking Univ, Sch Publ Hlth, Dept Epidemiol, Hlth Sci Ctr, Beijing, Peoples R China
242.Univ Hosp Leipzig, Inst Lab Med, Leipzig, Germany
243.NIA, Lab Epidemiol & Populat Sci, NIH, Baltimore, MD 21224 USA
244.Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku, Finland
245.Jichi Med Univ, Dept Environm & Prevent Med, Sch Med, Shimotsuke, Tochigi, Japan
246.Univ Edinburgh, Ctr Populat Hlth Sci, Usher Inst, Edinburgh, Midlothian, Scotland
247.Shimane Univ, Dept Funct Pathol, Sch Med, Izumo, Shimane, Japan
248.Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland
249.Univ Turku, Turku, Finland
250.Univ Turku, Dept Physiol, Turku, Finland
251.Univ Split, Fac Med, Split, Croatia
252.Univ Leipzig Med Ctr, Med Dept Endocrinol Nephrol Rheumatol 3, Leipzig, Germany
253.Harokopio Univ, Dept Nutr Dietet, Athens, Greece
254.Osaka Univ, Dept Clin Gene Therapy, Grad Sch Med, Suita, Osaka, Japan
255.Osaka Univ, Dept Geriatr & Gen Med, Grad Sch Med, Suita, Osaka, Japan
256.Univ Utrecht, Univ Med Ctr Utrecht, Dept Vasc Surg, Div Surg Specialties, Utrecht, Netherlands
257.Yonsei Univ, Corneal Dystrophy Res Inst, Dept Ophthalmol, Coll Med, Seoul, South Korea
258.Univ Med Ctr Rotterdam, Dept Radiol & Nucl Med, Erasmus MC, Rotterdam, Netherlands
259.Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
260.Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Med Sch, Dept Cardiol 2, Athens, Greece
261.Univ Sydney, Ctr Vis Res, Dept Ophthalmol, Sydney, NSW, Australia
262.Univ Sydney, Westmead Inst, Sydney, NSW, Australia
263.Univ Tasmania, Sch Med, Menzies Inst Med Res, Hobart, Tas, Australia
264.Univ Melbourne, Ctr Eye Res Australia, Sydney, NSW, Australia
265.Tampere Univ Hosp, Dept Clin Physiol, Tampere, Finland
266.Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Physiol, Tampere, Finland
267.Univ Laval, Inst Nutr & Funct Foods INAF, Quebec City, PQ, Canada
268.Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA
269.Univ Western Australia, Fac Hlth & Med Sci, Med Sch, Perth, WA, Australia
270.Univ Kiel, Inst Epidemiol, Kiel, Germany
271.Univ Kiel, Inst Clin Mol Biol, Kiel, Germany
272.Sahlgrens Univ Hosp, Dept Drug Treatment, Gothenburg, Sweden
273.Univ Gothenburg, Sahlgrenska Acad, Inst Med, Geriatr Med, Gothenburg, Sweden
274.Ewha Womans Univ, Dept Internal Med, Sch Med, Seoul, South Korea
275.Univ Pittsburgh, UPMC Hillman Canc Ctr, Div Canc Control & Populat Sci, Pittsburgh, PA USA
276.Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA
277.Natl Univ Singapore, Yong Loo Lin Sch Med, Hlth Longev Translat Res Programme, Singapore, Singapore
278.ASTAR, Singapore Inst Clin Sci, Singapore, Singapore
279.Kyung Hee Univ, Dept Endocrinol & Metab, Sch Med, Seoul, South Korea
280.Univ Med Greifswald, Inst Community Med, Greifswald, Germany
281.Univ Turku, Paavo Nurmi Ctr, Dept Phys Act & Hlth, Sports & Exercise Med Unit, Turku, Finland
282.Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, Groningen, Netherlands
283.Natl Res Council Italy, Inst Mol Genet, Pavia, Italy
284.Med Univ Graz, Gottfried Schatz Res Ctr Cell Signaling Metab & A, Graz, Austria
285.Toscana Ctr, Local Hlth Unit, Florence, Italy
286.Univ Potsdam, Inst Nutr Sci, Nuthetal, Germany
287.Traunstein Hosp, Dept Nephrol Diabetol Rheumatol, Traunstein, Germany
288.KfH Kidney Ctr Traunstein, Traunstein, Germany
289.Columbia Univ, Ctr Translat & Syst Neuroimmunol, Dept Neurol, Med Ctr, New York, NY USA
290.Broad Inst, Program Med & Populat Genet, Cambridge, MA USA
291.Natl & Kapodistrian Univ Athens, Med Sch, Athens, Greece
292.Dromokaiteio Psychiat Hosp, Athens, Greece
293.Queen Mary Univ London, William Harvey Res Inst, Clin Pharmacol, London, England
294.Heidelberg Univ, Med Fac Mannheim, Dept Ophthalmol, Mannheim, Germany
295.Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing Inst Ophthalmol, Beijing, Peoples R China
296.Inst Mol & Clin Ophthalmol Basel, Basel, Switzerland
297.Harvard Med Sch, Boston, MA 02115 USA
298.Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA
299.Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Unidad Biol Mol & Med Genom, Mexico City, DF, Mexico
300.UNAM, Inst Invest Biomed, Ciudad De Mexico, Mexico
301.Inst Invest Bimed UNAM, Unidad Biol Mol & Med Genom, Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, Mexico
302.Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Endocrinol & Metabol, Mexico City, DF, Mexico
303.Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Direcc Nutr, Mexico City, DF, Mexico
304.Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Unidad Estudios Enfermedades Metab, Mexico City, DF, Mexico
305.Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Nutr, Chapel Hill, NC USA
306.Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC USA
307.Univ San Carlos, USC Off Populat Studies Fdn, Cebu, Philippines
308.Univ San Carlos, Dept Anthropol Sociol & Hist, Cebu, Philippines
309.Univ Kelaniya, Fac Med, Dept Med, Ragama, Sri Lanka
310.Univ Kelaniya, Fac Med, Dept Publ Hlth, Ragama, Sri Lanka
311.Univ Calif San Francisco, Dept Pediat, San Francisco, CA USA
312.Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA
313.Acad Sinica, Inst Biomed Sci, Taipei, Taiwan
314.Jawaharlal Nehru Univ, Sch Biotechnol, Syst Genom Lab, New Delhi, India
315.Univ Mississippi, Med Ctr, Dept Med, Jackson, MS 39216 USA
316.Univ Mississippi, Med Ctr, Dept Physiol & Biophys, Jackson, MS 39216 USA
317.Uppsala Univ, Dept Med Sci, Uppsala, Sweden
318.Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Paediat, Singapore, Singapore
319.Natl Univ Hlth Syst, Khoo Teck Puat Natl Univ Childrens Med Inst, Singapore, Singapore
320.Univ N Carolina, Dept Med, Chapel Hill, NC USA
321.Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA
322.Univ N Carolina, Injury Prevent Res Ctr, Chapel Hill, NC USA
323.Univ N Carolina, Div Phys Therapy, Chapel Hill, NC USA
324.Vrije Univ Amsterdam, Dept Psychiat, Amsterdam UMC, Amsterdam, Netherlands
325.Ewha Womans Univ, Coll Med, Dept Biochem, Seoul, South Korea
326.Univ Newcastle, Fac Hlth & Med, Newcastle, NSW, Australia
327.Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA
328.Univ Kentucky, Coll Publ Hlth, Lexington, KY USA
329.Newcastle Univ, Med Sch, Inst Cellular Med Diabet, Newcastle Upon Tyne, Tyne & Wear, England
330.Finnish Inst Hlth & Welf, Dept Populat Hlth, Helsinki, Finland
331.Univ Helsinki, Helsinki, Finland
332.Helsinki Univ Hosp, Dept Med, Helsinki, Finland
333.Minerva Fdn, Helsinki, Finland
334.Acad Sci & Innovat Res AcSIR, New Delhi, India
335.KEM Hosp & Res Ctr, Diabetol Res Ctr, Pune, Maharashtra, India
336.Broad Inst MIT & Harvard, Program Metab & Med, Cambridge, MA 02142 USA
337.Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02114 USA
338.Inst Nacl Salud Publ, Cuernavaca, Morelos, Mexico
339.Ctr Estudios Diabet, Cuernavaca, Morelos, Mexico
340.Inst Nacl Med Genom, Mexico City, DF, Mexico
341.Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Sch Publ Hlth, Houston, TX 77030 USA
342.Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore
343.Kurume Univ, Sch Med, Kurume, Fukuoka, Japan
344.Merck Sharp & Dohme Ltd, Kenilworth, NJ USA
345.Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England
346.Univ Dundee, Ninwells Hosp & Med Sch, Populat Hlth & Genom, Dundee, Scotland
347.NIA, Intramural Res Program, Baltimore, MD 21224 USA
348.Wenzhou Med Univ, Eye Hosp, Sch Ophthalmol & Optometry, Wenzhou, Peoples R China
349.Synlab Acad, Synlab, Mannheim, Germany
350.Med Univ Graz, Clin Inst, Med & Chem Lab Diagnost, Graz, Austria
351.Inst Mexicano Seguro Social, Ctr Med Nacl Siglo 21, Hosp Especialidades, Unidad Invest Med Bioquim, Mexico City, DF, Mexico
352.Univ Iceland, Fac Med, Reykjavik, Iceland
353.Univ Montreal, Dept Med, Fac Med, Quebec City, PQ, Canada
354.Univ Montreal, Dept Med, Fac Med, Montreal, PQ, Canada
355.Leiden Univ Med Ctr, Dept Biomed Data Sci, Sect Mol Epidemiol, Leiden, Netherlands
356.Amsterdam UMC, Dept Gen Practice & Elderly Care, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands
357.Univ Penn, Dept Genet, Philadelphia, PA 19104 USA
358.Univ Penn, Dept Med, Perelman Sch Med, Philadelphia, PA 19104 USA
359.Univ Penn, Dept Surg, Philadelphia, PA 19104 USA
360.Corporal Michael Crescenz VA Med Ctr, Philadelphia, PA USA
361.Univ Essex, Inst Social & Econ Res, Colchester, Essex, England
362.Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA
363.Univ Washington, Dept Med Epidemiol & Hlth Serv, Cardiovasc Hlth Res Unit, Seattle, WA USA
364.Kaiser Permanent Washington Hlth Res Inst, Seattle, WA USA
365.Univ Southern Denmark, Inst Reg Hlth Res, Odense, Denmark
366.Univ Southern Denmark, Danish Aging Res Ctr, Odense, Denmark
367.Univ Helsinki, Fac Med, Publ Hlth, Helsinki, Finland
368.Broad Inst MIT & Harvard, Cambridge, MA 02142 USA
369.Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA
370.Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA
371.Childrens Hosp Philadelphia, Div Human Genet, Philadelphia, PA 19104 USA
372.Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China
373.Univ Lubeck, DZHK German Res Ctr Cardiovasc Res, Inst Cardiogenet, Partner Site Hamburg Lubeck Kiel, Lubeck, Germany
374.Univ Heart Ctr Lubeck, Lubeck, Germany
375.Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany
376.Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark
377.Netherlands Heart Inst, Utrecht, Netherlands
378.Massachusetts Gen Hosp, Dept Med, Div Cardiol, Boston, MA USA
379.Harvard Med Sch, Dept Med, Boston, MA 02115 USA
380.Univ Oulu, Fac Med, Infrastruct Populat Studies, Northern Finland Birth Cohorts, Oulu, Finland
381.Univ Oulu, Fac Med, Ctr Life Course Hlth Res, Oulu, Finland
382.Univ Oulu, Bioctr Oulu, Oulu, Finland
383.Univ Ctr Primary Care & Publ Hlth, Lausanne, Switzerland
384.Univ Sassari, Sassari, Italy
385.Leiden Univ Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands
386.Leiden Univ Med Ctr, Dept Publ Hlth & Primary Care, Leiden, Netherlands
387.Leiden Univ Med Ctr, Dept Internal Med, Div Endocrinol, Leiden, Netherlands
388.Leiden Univ Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands
389.Leiden Univ Med Ctr, Dept Human Genet, Leiden, Netherlands
390.Univ Oxford, John Radcliffe Hosp, Radcliffe Dept Med, Div OfCardiovasc Med, Oxford, England
391.St Georges Univ London, Populat Hlth Res Inst, London, England
392.Imperial Coll London, Natl Heart & Lung Inst, London, England
393.Imperial Coll London, Sch Publ Hlth, London, England
394.Univ Oxford, Churchill Hosp, OCDEM, Oxford, England
395.Churchill Hosp, NIHR Oxford Biomed Res Ctr, Oxford, England
396.Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore, Singapore
397.DZHK German Ctr Cardiovasc Res, Munich Heart Alliance Partner Site, Munich, Germany
398.Univ Exeter, Univ Exeter Med Sch, Exeter, Devon, England
399.Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
400.VU Med Ctr Amsterdam, Amsterdam Reprod & Dev Res Inst, Amsterdam, Netherlands
401.NHLBI, Framingham Heart Study, US Natl Inst Hlth, Bldg 10, Bethesda, MD 20892 USA
402.Mashhad Univ Med Sci, Sch Med, Dept Genet, Mashhad, Iran
403.Chinese Natl Human Genome Ctr Shanghai, Dept Genet, Shanghai MOST Key Lab Hlth & Dis Genom, Shanghai, Peoples R China
404.Tech Univ Munich TUM, TUM Sch Med, Munich, Germany
405.Klinikum Rechts Der Isar, Munich, Germany
406.Univ Eastern Finland, Inst Clin Med, Internal Med, Kuopio, Finland
407.Kuopio Univ Hosp, Kuopio, Finland
408.Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA
409.Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA USA
410.Regeneron Pharmaceut, Tarrytown, NY USA
411.Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore
412.Imperial Coll Healthcare NHS Trust, Imperial Coll London, London, England
413.Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England
414.Univ Illinois, Coll Med, Inst Minor Hlth Res, Chicago, IL USA
415.Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA
416.QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia
417.Faisalabad Inst Cardiol, Faislabad, Pakistan
418.Columbia Univ, Dept Med, Irving Med Ctr, New York, NY USA
419.Columbia Univ, Dept Cardiol, Irving Med Ctr, New York, NY USA
420.Univ Oxford, Big Data Inst, Oxford, England
421.Oxford Univ Hosp, Natl Inst Hlth Res, Oxford Biomed Res Ctr, Oxford, England
422.Univ Aberdeen, Aberdeen Ctr Hlth Data Sci, Sch Med, Aberdeen, Scotland
423.Univ Dundee, Ninewells Hosp & Med Sch, Div Populat Hlth & Genom, Dundee, Scotland
424.Geisinger Hlth, Biomed & Translat Informat, Danville, PA USA
425.Vanderbilt Univ Sch Med, Dept Biomed Informat, Nashville, TN USA
426.Univ Washington, Med Ctr, Dept Med Med Genet, Seattle, WA USA
427.Cincinnati Childrens Hosp Med Ctr CCHMC, Ctr Autoimmune Genom & Etiol, Cincinnati, OH USA
428.Northwestern Univ, Dept Med, Div Endocrinol, Feinberg Sch Med, Chicago, IL 60611 USA
429.Northwestern Univ, Dept Anthropol, Evanston, IL 60208 USA
430.Northwestern Univ, Feinberg Sch Med, Ctr Genet Med, Chicago, IL 60611 USA
431.Norwegian Univ Sci & Technol, HUNT Res Ctr, Dept Publ Hlth & Nursing, NTNU, Levanger, Norway
432.Levanger Hosp, Nord Trondelag Hosp Trust, Dept Med, Levanger, Norway
433.Trondheim Reg & Univ Hosp, Dept Endocrinol, St Olavs Hosp, Trondheim, Norway
434.RIKEN Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan
435.Univ Tokyo, Grad Sch Frontier Sci, Dept Computat Biol & Med Sci, Lab Complex Trait Genom, Tokyo, Japan
436.Osaka Univ, WPI Immunol Frontier Res Ctr, Lab Stat Immunol, Osaka, Japan
437.Osaka Univ, Inst Open & Transdisciplinary Res Initiat, Integrated Frontier Res Med Sci Div, Osaka, Japan
438.Univ Tokyo, Inst Med Sci, Div Mol Pathol, Tokyo, Japan
439.VA Boston Healthcare Syst, Boston, MA USA
440.VA Salt Lake City Hlth Care Syst, VA Informat & Comp Infrastruct, Salt Lake City, UT USA
441.Univ Massachusetts, Boston, MA 02125 USA
442.Stanford Univ, Cardiovasc Inst, Sch Med, Stanford, CA 94305 USA
443.Corporal Michael J Crescenz VA Med Ctr, Philadelphia, PA USA
444.Brigham & Womens Hosp, Dept Med, 75 Francis St, Boston, MA 02115 USA
445.Atlanta VA Med Ctr, Atlanta, GA USA
446.Emory Univ, Sch Med, Div Cardiol, Atlanta, GA USA
447.Univ Witwatersrand, Sch Elect & Informat Engn, Johannesburg, South Africa
448.Univ Witwatersrand, Fac Hlth Sci, Natl Hlth Lab Serv, Div Human Genet, Johannesburg, South Africa
449.Univ Witwatersrand, Fac Hlth Sci, Sch Pathol, Johannesburg, South Africa
450.Kings Coll London, Fac Life Sci & Med, Sch Basic & Med Biosci, London, England
451.Harvard Med Sch, Dept Pediat, Boston, MA USA
452.Harvard Med Sch, Dept Genet, Boston, MA USA
453.Massachusetts Gen Hosp, Dept Med, Ctr Genom Med, Boston, MA 02114 USA
454.Massachusetts Gen Hosp, Harvard Med Sch, Cardiol Div, Boston, MA USA
455.Harvard Med Sch, Massachusetts Gen Hosp, Dept Med, Boston, MA 02115 USA
456.Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA
457.Univ Manchester, Ctr Genet & Genom Versus Arthrit, Ctr Musculoskeletal Res, Div Musculoskeletal & Dermatol Sci, Manchester, Lancs, England
458.King Abdulaziz Univ, Princess Al Jawhara Al Brahim Ctr Excellence Res, Jeddah, Saudi Arabia
459.Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA

Graham, Sarah E.,Clarke, Shoa L.,Wu, Kuan-Han H.,et al. The power of genetic diversity in genome-wide association studies of lipids[J]. NATURE,2021.

Graham, Sarah E..,Clarke, Shoa L..,Wu, Kuan-Han H..,Kanoni, Stavroula.,Zajac, Greg J. M..,...&Willer, Cristen J..(2021).The power of genetic diversity in genome-wide association studies of lipids.NATURE.

Graham, Sarah E.,et al."The power of genetic diversity in genome-wide association studies of lipids".NATURE (2021).